HitPredict

Interactor 1: RAC1 (P40792)
Ras-related protein Rac1
Gene: RAC1

Interactor 2: FRL (Q9VUC6)
Formin-like protein (Formin related in leukocytes)
Gene: FRL

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	26801180
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Drf_FH3~Ras, Drf_GBD~Ras
Common GO terms	GO:0005829 - cytosol GO:0008360 - regulation of cell shape GO:0030866 - cortical actin cytoskeleton organization GO:0048675 - axon extension
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Dm			1 1183
+	Hs
		581155 RAC2_HUMAN (1-192): 3.07e-81: 241: 89.06		FMNL3_HUMAN (75-1165): 0: 892: 40.55
+	Hs
		988622 RAC1_HUMAN (1-192): 7.26e-85: 250: 91.67		FMNL2_HUMAN (75-1165): 0: 868: 40.45
+	Hs
		988853 RAC1_HUMAN (1-192): 7.26e-85: 250: 91.67		DAAM1_HUMAN (144-1142): 0: 709: 21.18
+	Hs
		581391 RAC2_HUMAN (1-192): 3.07e-81: 241: 89.06		DAAM1_HUMAN (144-1142): 0: 709: 21.18
+	Hs
		988751 RAC1_HUMAN (1-192): 7.26e-85: 250: 91.67		DIAP3_HUMAN (192-1154): 0: 658: 16.93
+	Hs
		581318 RAC2_HUMAN (1-192): 3.07e-81: 241: 89.06		DIAP3_HUMAN (192-1154): 0: 658: 16.93
+	Hs
		1433530 RHOJ_HUMAN (2-190): 4.29e-80: 239: 60.32		DIAP3_HUMAN (192-1154): 0: 658: 16.93
+	Hs
		252441 RAC1_HUMAN (1-192): 7.26e-85: 250: 91.67		DIAP1_HUMAN (190-1168): 0: 624: 17.78
+	Dd
		757431 RAC1A_DICDI (1-192): 1.7e-81: 241: 79.38		FORH_DICDI (193-1129): 0: 577: 18.77
+	Hs
		988403 RAC1_HUMAN (1-192): 7.26e-85: 250: 91.67		INF2_HUMAN (227-1176): 2.48e-147: 477: 18.52
+	Hs
		581080 RAC2_HUMAN (1-192): 3.07e-81: 241: 89.06		INF2_HUMAN (227-1176): 2.48e-147: 477: 18.52
+	Hs
		337577 RAC1_HUMAN (1-192): 7.26e-85: 250: 91.67		FMNL1_HUMAN (682-1165): 1.98e-122: 406: 35.33
+	Hs
		337556 RAC2_HUMAN (1-192): 3.07e-81: 241: 89.06		FMNL1_HUMAN (682-1165): 1.98e-122: 406: 35.33
+	Hs
		337613 RHOJ_HUMAN (2-190): 4.29e-80: 239: 60.32		FMNL1_HUMAN (682-1165): 1.98e-122: 406: 35.33
+	Hs
		988862 RAC1_HUMAN (1-192): 7.26e-85: 250: 91.67		FHOD1_HUMAN (204-1179): 8.16e-105: 359: 14.93
+	Dm
		117993 RAC1_DROME (1-192): 1.62e-82: 244: 100.00		M9MRS9_DROME (685-1177): 8.54e-102: 354: 17.06
+	Hs
		988766 RAC1_HUMAN (1-192): 7.26e-85: 250: 91.67		FMN2_HUMAN (643-1099): 3.93e-97: 343: 21.59
+	Hs
		258558 RAC1_HUMAN (1-192): 7.26e-85: 250: 91.67		DIAP2_HUMAN (81-507): 2.12e-13: 77.2: 15.03
+	Hs
		258546 RAC2_HUMAN (1-192): 3.07e-81: 241: 89.06		DIAP2_HUMAN (81-507): 2.12e-13: 77.2: 15.03
+	Hs
		258570 RHOJ_HUMAN (2-190): 4.29e-80: 239: 60.32		DIAP2_HUMAN (81-507): 2.12e-13: 77.2: 15.03