HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: HNRH1 (P31943)
Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed]
Gene: HNRNPH1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	24189400, 18271526, 15657067
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0016020 - membrane
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 449
+	Hs
		383565 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PABP1_HUMAN (1-446): 2.77e-84: 272: 13.70
+	Hs
		383713 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		HNRH2_HUMAN (1-449): 9.37e-73: 237: 96.21
+	Hs
		601824 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		HNRH1_HUMAN (1-449): 1.86e-75: 244: 100.00
+	Hs
		601862 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		HNRH2_HUMAN (1-449): 9.37e-73: 237: 96.21
+	Hs
		338165 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HNRPF_HUMAN (253-438): 2.66e-11: 67.3: 26.06
+	Hs
		337914 EGFR_HUMAN (1-1210): 0: 1241: 100.00		NUCL_HUMAN (75-373): 1.19e-09: 62.5: 18.89
+	Hs
		601859 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		HNRPF_HUMAN (253-438): 2.66e-11: 67.3: 26.06
+	Hs
		601823 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		HNRH3_HUMAN (10-86): 1.84e-10: 64.1: 32.47
+	Hs
		582064 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		NUCL_HUMAN (75-373): 1.19e-09: 62.5: 18.89
+	Rn
		88882 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		D4A233_RAT (1-446): 1.16e-78: 255: 14.35
+	Hs
		582156 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		NUCL_HUMAN (75-373): 1.19e-09: 62.5: 18.89
+	Rn
		86375 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		C1KE06_RAT (19-344): 1.04e-09: 62.5: 17.46
+	Hs
		796577 KSYK_HUMAN (716-961): 1.13e-53: 201: 41.70		SART3_HUMAN (2-217): 8.31e-16: 82.1: 23.89
+	Hs
		796556 KSYK_HUMAN (716-961): 1.13e-53: 201: 41.70		GRSF1_HUMAN (100-250): 4.41e-15: 79.1: 21.69