HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.733

Property	Details
Experiments	25402006, 24658140, 20029029, 12006493, 18271526, unassigned2173
Identification Methods	two hybrid, protein complementation assay, affinity chromatography technology, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 840
+	Hs
		320783 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HS74L_HUMAN (1-840): 0: 959: 63.21
+	Hs
		338778 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HS105_HUMAN (1-840): 0: 938: 62.95
+	Hs
		383646 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		320789 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		HS74L_HUMAN (1-840): 0: 959: 63.21
+	Hs
		338520 EGFR_HUMAN (1-1210): 0: 1241: 100.00		Q59EJ3_HUMAN (571-686): 5.38e-20: 97.4: 23.93
+	Hs
		337839 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		338516 EGFR_HUMAN (1-1210): 0: 1241: 100.00		Q53GZ6_HUMAN (564-692): 6.29e-20: 97: 16.92
+	Hs
		337827 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HS71A_HUMAN (571-686): 1.59e-19: 95.5: 23.93
+	Hs
		338019 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48
+	Hs
		320795 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		HS74L_HUMAN (1-840): 0: 959: 63.21
+	Hs
		1072565 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		HS105_HUMAN (1-840): 0: 938: 62.95
+	Hs
		338514 EGFR_HUMAN (1-1210): 0: 1241: 100.00		Q53FC7_HUMAN (587-690): 3.01e-16: 85.1: 22.86
+	Hs
		411458 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		HS105_HUMAN (1-840): 0: 938: 62.95
+	Hs
		383840 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		Q53FC7_HUMAN (587-690): 3.01e-16: 85.1: 22.86
+	Hs
		714128 ZAP70_HUMAN (718-961): 5.57e-53: 199: 39.59		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		503428 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		503499 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Rn
		544811 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		HSP7C_RAT (564-692): 1.76e-19: 95.5: 16.15
+	Hs
		503608 ABL2_HUMAN (707-974): 5.53e-52: 202: 40.37		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		483751 KSYK_HUMAN (716-961): 1.13e-53: 201: 41.70		HS71A_HUMAN (571-686): 1.59e-19: 95.5: 23.93