HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.997

The method score is based on:

Property Details
Experiments 11370743, 24189400, 27059931, 7650032, 20473329, 8665853, 8626525, 12577067, 11960376, 10085134, 31980649, 7527043, 31985874, 1322798, 10026169, 20124286, 9886492, 19836242, 9416834, 21706016 and 50 others

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Identification Methods affinity chromatography technology, pull down, two hybrid, protein complementation assay, proximity labelling technology, unspecified method, biochemical, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, coimmunoprecipitation and 5 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005768 - endosome
GO:0005886 - plasma membrane
GO:0007165 - signal transduction
and 3 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1210
Hs

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Last updated: 15 Jul 2024