HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: SHC2 (P98077)
SHC-transforming protein 2 (Protein Sck) (SHC-transforming protein B) (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2)
Gene: SHC2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.882

Property	Details
Experiments	24430869, 8610109, 22973453, 16273093
Identification Methods	affinity chromatography technology, pull down, unspecified method, protein array
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 582
+	Mm
		957227 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SHC1_MOUSE (1-581): 6.16e-124: 378: 44.89
+	Hs
		337988 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SHC1_HUMAN (1-581): 2.34e-124: 379: 45.41
+	Rn
		1129188 Q9QX70_RAT (1-1210): 0: 1241: 90.34		SHC1_RAT (96-581): 1.58e-119: 363: 50.30
+	Mm
		403432 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SRC_MOUSE (341-573): 3.33e-38: 149: 15.98
+	Hs
		337779 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FES_HUMAN (362-581): 5.35e-42: 163: 22.17
+	Hs
		337884 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FER_HUMAN (278-580): 1.08e-38: 154: 17.38
+	Hs
		337789 EGFR_HUMAN (1-1210): 0: 1241: 100.00		YES_HUMAN (330-573): 5.09e-39: 152: 16.41
+	Hs
		337850 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRC_HUMAN (326-573): 4.48e-39: 152: 15.06
+	Rn
		1351588 Q9QX70_RAT (1-1210): 0: 1241: 90.34		SRC_RAT (341-573): 1.37e-38: 151: 16.39
+	Hs
		208970 EGFR_HUMAN (1-1210): 0: 1241: 100.00		NCK2_HUMAN (271-578): 3.22e-39: 149: 13.29
+	Hs
		145963 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SH2B2_HUMAN (299-581): 3.55e-37: 148: 18.62
+	Hs
		338167 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VAV2_HUMAN (380-578): 2.05e-36: 147: 13.74
+	Hs
		337769 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LCK_HUMAN (321-582): 1.49e-36: 144: 14.60
+	Hs
		337804 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HCK_HUMAN (353-582): 1.9e-36: 144: 16.02
+	Hs
		275521 EGFR_HUMAN (1-1210): 0: 1241: 100.00		BCAR3_HUMAN (398-580): 2.03e-33: 138: 20.39
+	Hs
		337883 EGFR_HUMAN (1-1210): 0: 1241: 100.00		NCK1_HUMAN (456-574): 4.57e-35: 137: 24.59
+	Rn
		924998 Q9QX70_RAT (1-1210): 0: 1241: 90.34		GRB2_RAT (475-582): 1.32e-32: 126: 28.07
+	Hs
		337978 EGFR_HUMAN (1-1210): 0: 1241: 100.00		P85A_HUMAN (427-578): 3.1e-23: 106: 19.23
+	Mm
		964559 EGFR_MOUSE (1-1210): 0: 1258: 90.35		GRB2_MOUSE (475-582): 4.98e-16: 79.1: 27.68
+	Hs
		338251 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GRB2_HUMAN (475-582): 5.69e-16: 79.1: 28.07