HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: Q96D37 (Q96D37)
VAV1 protein (Vav guanine nucleotide exchange factor 1)
Gene: VAV1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.80	0.579

Property	Details
Experiments	16273093
Identification Methods	protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C1_1~PK_Tyr_Ser-Thr, CH~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 790
+	Mm
		654977 EGFR_MOUSE (1-1210): 0: 1258: 90.35		VAV_MOUSE (12-790): 0: 607: 92.56
+	Hs
		337872 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VAV_HUMAN (12-790): 0: 613: 99.74
+	Hs
		339121 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VAV3_HUMAN (12-786): 6.17e-179: 536: 55.74
+	Hs
		548711 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		VAV_HUMAN (12-790): 0: 613: 99.74
+	Hs
		338167 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VAV2_HUMAN (12-784): 4.04e-162: 494: 45.22
+	Hs
		383580 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		VAV_HUMAN (12-790): 0: 613: 99.74
+	Hs
		1071026 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		VAV3_HUMAN (12-786): 6.17e-179: 536: 55.74
+	Hs
		855797 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		VAV2_HUMAN (12-784): 4.04e-162: 494: 45.22
+	Hs
		383705 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		VAV2_HUMAN (12-784): 4.04e-162: 494: 45.22
+	Hs
		338801 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ARHG2_HUMAN (28-630): 1.09e-73: 261: 14.93
+	Hs
		224717 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		KALRN_HUMAN (85-612): 8.98e-65: 238: 16.67
+	Hs
		383913 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		ARHG2_HUMAN (28-630): 1.09e-73: 261: 14.93
+	Mm
		964571 EGFR_MOUSE (1-1210): 0: 1258: 90.35		ARHG7_MOUSE (686-788): 3.43e-15: 82.1: 24.27
+	Mm
		964559 EGFR_MOUSE (1-1210): 0: 1258: 90.35		GRB2_MOUSE (732-783): 1.13e-14: 75.9: 48.08
+	Hs
		338419 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ARHG7_HUMAN (686-788): 2.09e-15: 82.5: 23.30
+	Hs
		338251 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GRB2_HUMAN (732-783): 1.09e-14: 75.9: 48.08
+	Rn
		924998 Q9QX70_RAT (1-1210): 0: 1241: 90.34		GRB2_RAT (732-783): 1.09e-14: 75.9: 48.08
+	Hs
		338478 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITSN1_HUMAN (316-788): 1.05e-10: 67.9: 11.00
+	Hs
		924589 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		GRB2_HUMAN (732-783): 1.09e-14: 75.9: 48.08
+	Hs
		383730 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		GRB2_HUMAN (732-783): 1.09e-14: 75.9: 48.08