HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: HOOK2 (Q96ED9)
Protein Hook homolog 2 (h-hook2) (hHK2)
Gene: HOOK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	23956138
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 719
+	Hs
		338037 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MYH9_HUMAN (347-719): 2.16e-16: 85.9: 10.72
+	Hs
		338732 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DLG5_HUMAN (187-645): 1.59e-15: 83: 16.84
+	Hs
		338508 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GRDN_HUMAN (37-565): 6.81e-15: 81.3: 14.55
+	Hs
		338478 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITSN1_HUMAN (129-552): 2.56e-14: 79.2: 17.09
+	Hs
		339106 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HOOK1_HUMAN (328-719): 5.67e-10: 64.7: 11.88
+	Hs
		254427 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ROCK2_HUMAN (179-532): 3.76e-09: 62.2: 14.32
+	Hs
		383838 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		GRDN_HUMAN (37-565): 6.81e-15: 81.3: 14.55
+	Hs
		384010 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		DAPLE_HUMAN (253-718): 2.4e-10: 66.4: 16.49
+	Hs
		601954 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		DLG5_HUMAN (187-645): 1.59e-15: 83: 16.84
+	Hs
		665608 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		ITSN1_HUMAN (129-552): 2.56e-14: 79.2: 17.09
+	Hs
		665293 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		DLG5_HUMAN (187-645): 1.59e-15: 83: 16.84
+	Hs
		305100 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		RIMB1_HUMAN (159-374): 4.7e-12: 71.9: 20.46
+	Rn
		94275 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		F1LUA1_RAT (156-718): 1.14e-19: 96.7: 12.88
+	Hs
		665375 EPHA3_HUMAN (654-981): 7.78e-111: 372: 34.51		MYH9_HUMAN (347-719): 2.16e-16: 85.9: 10.72
+	Hs
		411404 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		GRDN_HUMAN (37-565): 6.81e-15: 81.3: 14.55
+	Mm
		222875 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		MYH9_MOUSE (378-719): 1.26e-15: 83.6: 11.95
+	Mm
		222845 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		MYH10_MOUSE (362-719): 3.28e-14: 79: 13.28
+	Mm
		222882 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		MY18A_MOUSE (174-662): 8.32e-11: 68: 14.98