HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: HBEGF (Q99075)
Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor (HB-EGF) (HBEGF) (Diphtheria toxin receptor) (DT-R)]
Gene: HBEGF

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.77 0.60 0.683

The method score is based on:

Property Details
Experiments 15358134, 12725245, 9135143, 28988771
Identification Methods pull down, affinity chromatography technology, cross-linking study, x ray scattering
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005615 - extracellular space
GO:0005886 - plasma membrane
GO:0007165 - signal transduction
GO:0007173 - epidermal growth factor receptor signaling pathway
GO:0008284 - positive regulation of cell population proliferation
and 8 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 1210
Hs

1 208
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024