HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: DNJC4 (Q9NNZ3)
DnaJ homolog subfamily C member 4 (DnaJ-like protein HSPF2) (Multiple endocrine neoplasia type 1 candidate protein number 18)
Gene: DNAJC4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.608

Property	Details
Experiments	20029029, unassigned2173
Identification Methods	protein complementation assay, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 241
+	Hs
		338830 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DNJA3_HUMAN (3-191): 5.67e-43: 153: 21.69
+	Hs
		339164 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DJC16_HUMAN (32-199): 1.93e-37: 140: 15.48
+	Hs
		339080 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DJB11_HUMAN (33-134): 3.08e-36: 132: 26.47
+	Hs
		338003 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DNJA1_HUMAN (31-99): 2.12e-29: 115: 37.68
+	Hs
		338668 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DJC10_HUMAN (35-96): 3.42e-11: 64.3: 43.55
+	Hs
		243241 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DNJA2_HUMAN (36-96): 8.35e-09: 57: 47.54
+	Hs
		383929 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		DNJA3_HUMAN (3-191): 5.67e-43: 153: 21.69
+	Hs
		383889 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		DNJB8_HUMAN (34-154): 2.18e-37: 132: 25.41
+	Hs
		384016 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		DJB11_HUMAN (33-134): 3.08e-36: 132: 26.47
+	Hs
		383639 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		DNJA1_HUMAN (31-99): 2.12e-29: 115: 37.68
+	Hs
		602017 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		DJB11_HUMAN (33-134): 3.08e-36: 132: 26.47
+	Hs
		601821 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		DNJA1_HUMAN (31-99): 2.12e-29: 115: 37.68
+	Hs
		383876 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		DJC10_HUMAN (35-96): 3.42e-11: 64.3: 43.55
+	Hs
		243250 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		DNJA2_HUMAN (36-96): 8.35e-09: 57: 47.54
+	Hs
		434302 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		DJB11_HUMAN (33-134): 3.08e-36: 132: 26.47
+	Hs
		665354 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		DNJ5B_HUMAN (28-103): 5.22e-31: 115: 34.18
+	Hs
		411313 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		DNJA1_HUMAN (31-99): 2.12e-29: 115: 37.68
+	Hs
		243261 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		DNJA2_HUMAN (36-96): 8.35e-09: 57: 47.54
+	Hs
		411430 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		DJC10_HUMAN (35-96): 3.42e-11: 64.3: 43.55
+	Hs
		243254 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		DNJA2_HUMAN (36-96): 8.35e-09: 57: 47.54