HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: SMUF2 (Q9HAU4)
E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2)
Gene: SMURF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.678

Property	Details
Experiments	32669362, 33762435, 21750651
Identification Methods	affinity chromatography technology, enzymatic study, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0045121 - membrane raft GO:0090263 - positive regulation of canonical Wnt signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 748
+	Hs
		339005 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SMUF1_HUMAN (1-748): 0: 748: 70.44
+	Hs
		383984 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		SMUF2_HUMAN (1-748): 0: 834: 100.00
+	Hs
		338105 EGFR_HUMAN (1-1210): 0: 1241: 100.00		NEDD4_HUMAN (104-746): 0: 628: 38.73
+	Hs
		338634 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HUWE1_HUMAN (114-747): 0: 589: 31.46
+	Hs
		808132 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		NEDD4_HUMAN (104-746): 0: 628: 38.73
+	Hs
		601847 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		NEDD4_HUMAN (104-746): 0: 628: 38.73
+	Hs
		338861 EGFR_HUMAN (1-1210): 0: 1241: 100.00		NED4L_HUMAN (5-396): 1.96e-36: 149: 18.58
+	Hs
		338840 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITCH_HUMAN (1-426): 2.45e-23: 107: 16.44
+	Hs
		338959 EGFR_HUMAN (1-1210): 0: 1241: 100.00		WWP1_HUMAN (2-395): 4.38e-20: 97.5: 15.47
+	Hs
		339072 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HECW2_HUMAN (19-281): 8.01e-17: 87.5: 14.80
+	Hs
		1070998 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		ITCH_HUMAN (1-426): 2.45e-23: 107: 16.44
+	Hs
		1071010 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		WWP1_HUMAN (2-395): 4.38e-20: 97.5: 15.47
+	Hs
		601981 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		NED4L_HUMAN (5-396): 1.96e-36: 149: 18.58
+	Hs
		601974 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		ITCH_HUMAN (1-426): 2.45e-23: 107: 16.44
+	Hs
		434157 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		NEDD4_HUMAN (104-746): 0: 628: 38.73
+	Hs
		992607 ACK1_HUMAN (691-967): 4.54e-56: 214: 39.58		SMUF1_HUMAN (1-748): 0: 748: 70.44
+	Hs
		808104 ACK1_HUMAN (691-967): 4.54e-56: 214: 39.58		NEDD4_HUMAN (104-746): 0: 628: 38.73
+	Hs
		992601 ACK1_HUMAN (691-967): 4.54e-56: 214: 39.58		NED4L_HUMAN (5-396): 1.96e-36: 149: 18.58
+	Hs
		125405 ACK1_HUMAN (691-967): 4.54e-56: 214: 39.58		WWP2_HUMAN (1-416): 7.64e-26: 116: 17.39
+	Hs
		992589 ACK1_HUMAN (691-967): 4.54e-56: 214: 39.58		HECW1_HUMAN (19-213): 6.29e-17: 87.9: 15.94