HitPredict

Interactor 1: NET1 (O95631)
Netrin-1 (Epididymis tissue protein Li 131P)
Gene: NTN1

Interactor 2: UNC5B (Q8IZJ1)
Netrin receptor UNC5B (Protein unc-5 homolog 2) (Protein unc-5 homolog B) (p53-regulated receptor for death and life protein 1) (p53RDL1)
Gene: UNC5B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	18719102, 26190107
Identification Methods	anti bait coimmunoprecipitation, avexis
Interaction Type	physical association

Property	Details
Interacting Pfam domains	NTR~TSP_1
Common GO terms	GO:0006915 - apoptotic process GO:0033564 - anterior/posterior axon guidance
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 604 Hs			1 945
+	Mm
		148762 NET1_MOUSE (1-604): 5.96e-177: 516: 99.17		UNC5B_MOUSE (1-945): 0: 933: 92.38
+	Mm
		148144 NET1_MOUSE (1-604): 5.96e-177: 516: 99.17		UNC5C_MOUSE (34-944): 0: 855: 64.98
+	Hs
		328769 NET1_HUMAN (1-604): 5.41e-177: 516: 100.00		UNC5C_HUMAN (34-944): 0: 850: 63.78
+	Dr
		72299 O42140_DANRE (2-604): 0: 527: 86.73		A9JR35_DANRE (28-945): 0: 822: 66.95
+	Mm
		148763 NET1_MOUSE (1-604): 5.96e-177: 516: 99.17		UNC5A_MOUSE (1-945): 0: 816: 51.74
+	Mm
		148761 NET1_MOUSE (1-604): 5.96e-177: 516: 99.17		UNC5D_MOUSE (48-944): 0: 777: 53.55
+	Hs
		340706 NET1_HUMAN (1-604): 5.41e-177: 516: 100.00		UNC5A_HUMAN (1-945): 0: 720: 44.25
+	Dm
		1175507 NETB_DROME (32-254): 4.63e-55: 201: 54.08		Q9W213_DROME (8-528): 4.5e-43: 172: 12.77
+	Dm
		1175313 NETB_DROME (32-254): 4.63e-55: 201: 54.08		Q9VQ08_DROME (2-284): 2.7e-33: 141: 16.95
+	Hs
		464445 LAMB3_HUMAN (250-454): 2.8e-20: 97.6: 22.54		TSP1_HUMAN (166-372): 6.45e-19: 94.6: 18.82