Interactor 1: C1R (P00736)
Complement C1r subcomponent (EC 3.4.21.41) (Complement component 1 subcomponent r) [Cleaved into: Complement C1r subcomponent heavy chain; Complement C1r subcomponent light chain]
Gene: C1R

Interactor 2: C1RL (Q9NZP8)
Complement C1r subcomponent-like protein (C1r-LP) (C1r-like protein) (EC 3.4.21.-) (C1r-like serine protease analog protein) (CLSPa)
Gene: C1RL

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.65 1.00 0.811

The method score is based on:

Property Details
Experiments 28514442, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains CUB~CUB, CUB~FXa_inhibition, FXa_inhibition~Trypsin, CUB~Sushi, Sushi~Trypsin, Trypsin~Trypsin
Common GO terms GO:0004252 - serine-type endopeptidase activity
GO:0005615 - extracellular space
GO:0006958 - complement activation, classical pathway
GO:0031638 - zymogen activation
GO:0045087 - innate immune response
and 2 others

more...

Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 705
Hs

1 487
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Last updated: 15 Jul 2024