HitPredict

Interactor 1: VATG2 (O95670)
V-type proton ATPase subunit G 2 (V-ATPase subunit G 2) (V-ATPase 13 kDa subunit 2) (Vacuolar proton pump subunit G 2)
Gene: ATP6V1G2

Interactor 2: VPP2 (Q9Y487)
V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2)
Gene: ATP6V0A2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	33961781, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	V-ATPase_G~V_ATPase_I
Common GO terms	GO:0016241 - regulation of macroautophagy GO:0046961 - proton-transporting ATPase activity, rotational mechanism
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 118 Hs			1 856
+	Hs
		276874 VATG1_HUMAN (1-118): 1.67e-31: 109: 63.56		VPP2_HUMAN (1-856): 0: 1321: 100.00
+	Mm
		1423769 VATG1_MOUSE (1-118): 5.19e-33: 113: 64.41		VPP1_MOUSE (1-842): 0: 1296: 52.83
+	Mm
		1490133 VATG2_MOUSE (1-117): 3.16e-30: 106: 95.73		VPP1_MOUSE (1-842): 0: 1296: 52.83
+	Hs
		276851 VATG1_HUMAN (1-118): 1.67e-31: 109: 63.56		VPP1_HUMAN (1-842): 0: 1278: 53.19
+	Hs
		341217 VATG2_HUMAN (1-118): 1.32e-30: 107: 100.00		VPP1_HUMAN (1-842): 0: 1278: 53.19
+	Hs
		341205 VATG2_HUMAN (1-118): 1.32e-30: 107: 100.00		VPP3_HUMAN (1-843): 0: 1082: 49.35
+	Sc
		740080 VATG_YEAST (3-113): 3.07e-23: 88.3: 32.43		VPP1_YEAST (3-842): 0: 1037: 36.46
+	Sc
		790333 VATG_YEAST (3-113): 3.07e-23: 88.3: 32.43		VPP2_YEAST (3-845): 0: 947: 33.19