Protein: VPP1
V-type proton ATPase subunit a, vacuolar isoform (V-ATPase a 1 subunit) (V-ATPase 95 kDa subunit) (Vacuolar pH protein 1) (Vacuolar proton pump a subunit) (Vacuolar proton translocating ATPase subunit a 1)

Gene: VPP1, VPH1
Organism: Saccharomyces cerevisiae S288C
Interactions: 114
UniProt ID: P32563

Gene Ontology (top 5):
GO:0000220 - vacuolar proton-transporting V-type ATPase, V0 domain
GO:0000324 - fungal-type vacuole
GO:0000329 - fungal-type vacuole membrane
GO:0006797 - polyphosphate metabolic process
GO:0007035 - vacuolar acidification

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

735697

VA0D
V-type proton ATPase subunit d

12

14

Small-scale

0.983

High

740071

VATH
V-type proton ATPase subunit H

9

3

Small-scale

0.971

High

726553

VATC
V-type proton ATPase subunit C

6

12

Small-scale

0.943

High

740080

VATG
V-type proton ATPase subunit G

6

8

Small-scale

0.937

High

645806

VATE
V-type proton ATPase subunit E

5

8

Small-scale

0.918

High

676536

VATL1
V-type proton ATPase subunit c

4

9

Small-scale

0.881

High

663592

VATO
V-type proton ATPase subunit c''

4

9

Small-scale

0.867

High

740042

VATL2
V-type proton ATPase subunit c'

4

9

Small-scale

0.867

High

740038

VPP1
V-type proton ATPase subunit a, vacuolar isoform

3

7

Small-scale

0.820

High

740113

VA0E
V-type proton ATPase subunit e

3

1

Small-scale

0.817

High

603434

VATA
V-type proton ATPase catalytic subunit A

12

16

Small-scale

0.758

High

740046

VPP2
V-type proton ATPase subunit a, Golgi isoform

2

7

Small-scale

0.754

High

592107

VATB
V-type proton ATPase subunit B

8

9

Small-scale

0.748

High

740060

VATF
V-type proton ATPase subunit F

6

6

Small-scale

0.738

High

740040

VATD
V-type proton ATPase subunit D

4

5

Small-scale

0.700

High

734794

VPH2
Vacuolar ATPase assembly integral membrane protein VPH2

3

0

Small-scale

0.642

High

740079

RAV1
Regulator of V-ATPase in vacuolar membrane protein 1

3

0

Small-scale

0.638

High

740056

ATC2
Calcium-transporting ATPase 2

2

2

Small-scale

0.614

High

740083

VOA1
V0 assembly protein 1

2

1

High-throughput

0.614

High

740064

VTC1
Vacuolar transporter chaperone complex subunit 1

2

3

Small-scale

0.611

High

740078

VTC4
Vacuolar transporter chaperone complex subunit 4

2

7

Small-scale

0.611

High

740053

VMA22
Vacuolar ATPase assembly protein VMA22

2

0

Small-scale

0.592

High

523386

HSP71
Heat shock protein SSA1

2

1

High-throughput

0.552

High

740051

FTH1
Iron transporter FTH1

1

0

High-throughput

0.518

High

740085

PRS10
26S proteasome subunit RPT4

1

2

High-throughput

0.494

High

740081

YOR1
Oligomycin resistance ATP-dependent permease YOR1

1

3

High-throughput

0.489

High

740106

NCE2
Non-classical export protein 2

1

0

High-throughput

0.481

High

575722

BPT1
Bile pigment transporter 1

1

3

High-throughput

0.479

High

628252

ZRC1
Vacuolar zinc transporter ZRC1

1

4

High-throughput

0.479

High

693172

PHO91
Low-affinity phosphate transporter PHO91

1

4

High-throughput

0.479

High

736175

YBT1
ATP-dependent bile acid permease

1

2

High-throughput

0.479

High

740041

COT1
Vacuolar zinc transporter COT1

1

4

High-throughput

0.479

High

740048

ATG8
Autophagy-related protein 8

1

1

High-throughput

0.479

High

740059

YCFI
Metal resistance protein YCF1

1

2

High-throughput

0.479

High

740062

KC13
Casein kinase I homolog 3

1

3

High-throughput

0.479

High

740068

SYG1
Protein SYG1

1

4

High-throughput

0.479

High

740072

VNX1
Low affinity vacuolar monovalent cation/H(+) antiporter

1

1

High-throughput

0.479

High

740073

VTC2
Vacuolar transporter chaperone complex subunit 2

1

7

High-throughput

0.479

High

740084

VSB1
Vacuolar basic amino acid transporter VSB1

1

3

High-throughput

0.479

High

740089

VTC3
Vacuolar transporter chaperone 3 complex subunit 3

1

7

High-throughput

0.479

High

740090

RMD1
Sporulation protein RMD1

1

1

High-throughput

0.479

High

740095

CSC1
Calcium permeable stress-gated cation channel 1

1

3

High-throughput

0.479

High

740101

SMF3
Iron transporter SMF3

1

1

High-throughput

0.479

High

740105

NPC1
NPC intracellular sterol transporter 1-related protein 1

1

4

High-throughput

0.479

High

740107

NYV1
Vacuolar v-SNARE NYV1

1

5

High-throughput

0.479

High

740112

YPK9
Vacuolar cation-transporting ATPase YPK9

1

2

High-throughput

0.479

High

740114

VCX1
Vacuolar calcium ion transporter

1

1

High-throughput

0.479

High

740111

CEX1
Cytoplasmic export protein 1

1

1

High-throughput

0.470

High

438652

SC160
Protein SCP160

1

0

High-throughput

0.458

High

547035

PPB
Repressible alkaline phosphatase

1

0

High-throughput

0.458

High

673285

ADP1
Probable ATP-dependent permease

1

0

High-throughput

0.458

High

740039

SEC17
Alpha-soluble NSF attachment protein

1

0

High-throughput

0.458

High

740044

AVT3
Vacuolar amino acid transporter 3

1

0

High-throughput

0.458

High

740049

PFF1
Vacuolar membrane protease

1

0

High-throughput

0.458

High

740057

VTC5
Vacuole transporter chaperone complex subunit 5

1

0

High-throughput

0.458

High

740063

VAC8
Vacuolar protein 8

1

0

High-throughput

0.458

High

740088

RAGAB
GTP-binding protein GTR1

1

0

Small-scale

0.458

High

740093

VBA4
Vacuolar basic amino acid transporter 4

1

0

High-throughput

0.458

High

740102

RTC5
Restriction of telomere capping protein 5

1

0

High-throughput

0.458

High

740109

YVC1
Calcium channel YVC1

1

0

High-throughput

0.458

High

526201

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

647056

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

1

High-throughput

0.437

High

679496

CDC48
Cell division control protein 48

1

1

High-throughput

0.437

High

705145

PEX3
Peroxisomal biogenesis factor 3

1

1

High-throughput

0.437

High

706533

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

740045

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

1

High-throughput

0.437

High

740075

RMD8
Sporulation protein RMD8

1

1

High-throughput

0.437

High

740087

NUM1
Nuclear migration protein NUM1

1

1

High-throughput

0.437

High

740097

LAM6
Membrane-anchored lipid-binding protein LAM6

1

1

Small-scale

0.437

High

740099

AP3D
AP-3 complex subunit delta

1

2

High-throughput

0.437

High

740103

ATG9
Autophagy-related protein 9

1

2

High-throughput

0.437

High

740110

DBP10
ATP-dependent RNA helicase DBP10

1

1

High-throughput

0.437

High

358159

ADH1
Alcohol dehydrogenase 1

1

1

High-throughput

0.407

High

544200

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

High-throughput

0.407

High

676707

GBP2
Serine/arginine

1

1

High-throughput

0.407

High

740066

SSB2
Ribosome-associated molecular chaperone SSB2

1

2

High-throughput

0.407

High

740070

VMA21
Vacuolar ATPase assembly integral membrane protein VMA21

4

0

Small-scale

0.359

High

726854

HS104
Heat shock protein 104

2

0

High-throughput

0.305

High

670483

SIS1
Protein SIS1

2

0

High-throughput

0.298

High

439291

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.279

Low

555040

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.279

Low

740058

LYS9
Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]

1

0

High-throughput

0.279

Low

740092

EMI2
Putative glucokinase-2

1

0

High-throughput

0.279

Low

740096

NOP6
Nucleolar protein 6

1

0

High-throughput

0.279

Low

740104

YRA1
RNA annealing protein YRA1

1

0

High-throughput

0.279

Low

740050

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

1

0

Small-scale

0.251

Low

740054

BIG1
Protein BIG1

1

0

Small-scale

0.251

Low

740108

SMT3
Ubiquitin-like protein SMT3

1

0

High-throughput

0.251

Low

558644

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

661482

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.249

Low

688982

RL16A
Large ribosomal subunit protein uL13A

1

0

High-throughput

0.249

Low

709638

BMH1
Protein BMH1

1

0

High-throughput

0.249

Low

740043

IXR1
Intrastrand cross-link recognition protein

1

0

Small-scale

0.249

Low

740047

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

740052

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.249

Low

740055

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.249

Low

740061

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

740065

YEY6
MYG1 protein YER156C

1

0

Small-scale

0.249

Low

740067

TM108
Protein TMA108

1

0

High-throughput

0.249

Low

740069

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

740074

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

0

High-throughput

0.249

Low

740077

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.249

Low

740082

PESC
Pescadillo homolog

1

0

High-throughput

0.249

Low

740086

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.249

Low

740091

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.249

Low

740094

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

740098

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

740100

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.249

Low

672384

STE50
Protein STE50

1

0

High-throughput

0.238

Low

427187

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.232

Low

486097

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.232

Low

597414

EF3A
Elongation factor 3A

1

0

High-throughput

0.232

Low

740076

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025