Protein: VPP3
V-type proton ATPase 116 kDa subunit a 3 (V-ATPase 116 kDa subunit a 3) (Osteoclastic proton pump 116 kDa subunit) (OC-116 kDa) (OC116) (T-cell immune regulator 1) (T-cell immune response cDNA7 protein) (TIRC7) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3)

Gene: VPP3, TCIRG1
Organism: Homo sapiens
Interactions: 80
UniProt ID: Q13488

Gene Ontology (top 5):
GO:0000045 - autophagosome assembly
GO:0000220 - vacuolar proton-transporting V-type ATPase, V0 domain
GO:0001503 - ossification
GO:0002158 - osteoclast proliferation
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

961516

VA0D1
V-type proton ATPase subunit d 1

2

14

High-throughput

0.789

High

1106798

VA0D2
V-type proton ATPase subunit d 2

2

14

High-throughput

0.789

High

692195

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

2

9

High-throughput

0.776

High

341205

VATG2
V-type proton ATPase subunit G 2

2

8

High-throughput

0.737

High

637103

VATC1
V-type proton ATPase subunit C 1

2

12

High-throughput

0.737

High

292624

RENR
Renin receptor

5

5

High-throughput

0.712

High

1106804

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

7

High-throughput

0.691

High

1106821

VPP2
V-type proton ATPase 116 kDa subunit a 2

1

7

High-throughput

0.691

High

784787

VATE1
V-type proton ATPase subunit E 1

1

8

High-throughput

0.618

High

224994

TLX3
T-cell leukemia homeobox protein 3

2

2

High-throughput

0.606

High

158820

AP3D1
AP-3 complex subunit delta-1

2

2

High-throughput

0.601

High

1106779

VAS1
V-type proton ATPase subunit S1

2

6

High-throughput

0.601

High

1106780

VATF
V-type proton ATPase subunit F

2

6

High-throughput

0.601

High

1106795

VMA12
Vacuolar ATPase assembly protein VMA12

2

6

High-throughput

0.601

High

1106808

VMA22
Vacuolar ATPase assembly protein VMA22

2

3

High-throughput

0.601

High

1106822

VATD
V-type proton ATPase subunit D

2

5

High-throughput

0.601

High

1106789

POGZ
Pogo transposable element with ZNF domain

2

0

High-throughput

0.580

High

1106799

VATC2
V-type proton ATPase subunit C 2

1

12

High-throughput

0.575

High

637018

VATB2
V-type proton ATPase subunit B, brain isoform

2

9

High-throughput

0.571

High

1106792

K2013
Uncharacterized protein KIAA2013

2

6

High-throughput

0.549

High

125015

KCNK1
Potassium channel subfamily K member 1

1

1

High-throughput

0.541

High

299180

FLOT1
Flotillin-1

1

1

High-throughput

0.536

High

320447

TM63A
Mechanosensitive cation channel TMEM63A

1

3

High-throughput

0.536

High

856674

BAG6
Large proline-rich protein BAG6

1

2

High-throughput

0.536

High

1043204

TAP2
Antigen peptide transporter 2

1

1

High-throughput

0.536

High

1106778

FLOT2
Flotillin-2

1

1

High-throughput

0.536

High

1106788

ATG9A
Autophagy-related protein 9A

1

2

High-throughput

0.536

High

1106805

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

1

High-throughput

0.536

High

1106816

ABCB9
ABC-type oligopeptide transporter ABCB9

1

1

High-throughput

0.536

High

1106823

KC1G3
Casein kinase I isoform gamma-3

1

2

High-throughput

0.536

High

928439

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.518

High

243797

ADCY3
Adenylate cyclase type 3

1

0

High-throughput

0.513

High

250592

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

High-throughput

0.513

High

582090

PGAM2
Phosphoglycerate mutase 2

1

0

High-throughput

0.513

High

774146

ADDB
Beta-adducin

1

0

High-throughput

0.513

High

1106786

KCNT2
Potassium channel subfamily T member 2

1

0

High-throughput

0.513

High

1106811

SORT
Sortilin

1

0

High-throughput

0.513

High

1106813

NFIP1
NEDD4 family-interacting protein 1

1

0

High-throughput

0.513

High

1106809

CYH2
Cytohesin-2

1

4

Small-scale

0.501

High

948095

AP3S2
AP-3 complex subunit sigma-2

1

1

High-throughput

0.489

High

1106781

VMA21
Vacuolar ATPase assembly integral membrane protein VMA21

1

3

High-throughput

0.489

High

1106785

TYW1B
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1B

1

1

High-throughput

0.489

High

1106796

TTC9C
Tetratricopeptide repeat protein 9C

1

3

High-throughput

0.489

High

1106800

ATLA2
Atlastin-2

1

1

High-throughput

0.489

High

1106820

GOT1B
Vesicle transport protein GOT1B

1

1

High-throughput

0.489

High

178259

NPC1
NPC intracellular cholesterol transporter 1

1

4

High-throughput

0.479

High

363236

EGFR
Epidermal growth factor receptor

1

2

High-throughput

0.479

High

1106794

EMC5
ER membrane protein complex subunit 5

1

2

High-throughput

0.479

High

132014

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.458

High

1106782

PKHN1
Pleckstrin homology domain-containing family N member 1

1

0

Small-scale

0.458

High

225808

AP1G1
AP-1 complex subunit gamma-1

1

2

High-throughput

0.445

High

609672

LEG3
Galectin-3

1

8

High-throughput

0.445

High

800482

VATA
V-type proton ATPase catalytic subunit A

1

13

High-throughput

0.445

High

845631

MUC18
Cell surface glycoprotein MUC18

1

5

High-throughput

0.445

High

965409

AP1S1
AP-1 complex subunit sigma-1A

1

1

High-throughput

0.445

High

1106791

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

5

High-throughput

0.445

High

1106803

LPAR1
Lysophosphatidic acid receptor 1

1

1

High-throughput

0.445

High

1106810

S1PR3
Sphingosine 1-phosphate receptor 3

1

1

High-throughput

0.445

High

1106797

EMC1
ER membrane protein complex subunit 1

1

2

High-throughput

0.437

High

638409

FPR1
fMet-Leu-Phe receptor

1

0

High-throughput

0.426

High

704007

5HT1E
5-hydroxytryptamine receptor 1E

1

0

High-throughput

0.426

High

1106787

LHPL2
LHFPL tetraspan subfamily member 2 protein

1

0

High-throughput

0.426

High

1106801

MO2R1
Cell surface glycoprotein CD200 receptor 1

1

0

High-throughput

0.426

High

1106802

RFFL
E3 ubiquitin-protein ligase rififylin

1

0

High-throughput

0.426

High

1106817

SCN3B
Sodium channel regulatory subunit beta-3

1

0

High-throughput

0.426

High

170751

CLGN
Calmegin

1

1

High-throughput

0.407

High

1106814

PCX3
Pecanex-like protein 3

1

3

High-throughput

0.407

High

1106783

DCA10
DDB1- and CUL4-associated factor 10

2

0

High-throughput

0.313

High

1106807

SARAF
Store-operated calcium entry-associated regulatory factor

2

0

High-throughput

0.313

High

1050356

ICA69
Islet cell autoantigen 1

1

0

High-throughput

0.279

Low

1103531

PDE3B
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

1

0

High-throughput

0.279

Low

1106790

GOGA7
Golgin subfamily A member 7

1

0

High-throughput

0.279

Low

1106793

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.279

Low

1106815

DJC18
DnaJ homolog subfamily C member 18

1

0

High-throughput

0.279

Low

1106818

TMX2
Thioredoxin-related transmembrane protein 2

1

0

High-throughput

0.279

Low

1106819

ZDHC9
Palmitoyltransferase ZDHHC9

1

0

High-throughput

0.279

Low

48237

TM129
E3 ubiquitin-protein ligase TM129

1

0

High-throughput

0.232

Low

1106784

PR15B
Protein phosphatase 1 regulatory subunit 15B

1

0

High-throughput

0.232

Low

1106806

LDAF1
Lipid droplet assembly factor 1

1

0

High-throughput

0.232

Low

1106812

GORS1
Golgi reassembly-stacking protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025