HitPredict

Interactor 1: HERC2 (O95714)
E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)
Gene: HERC2

Interactor 2: THOC6 (Q86W42)
THO complex subunit 6 (Functional spliceosome-associated protein 35) (fSAP35) (WD repeat-containing protein 58)
Gene: THOC6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29511261
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RCC1~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 4834 Hs			1 341
+	Hs
		342997 HERC2_HUMAN (1-4834): 0: 6292: 100.00		FBXW7_HUMAN (1-149): 1.68e-20: 94.4: 7.38
+	Hs
		131888 WWP2_HUMAN (4317-4794): 5.4e-171: 554: 19.46		WDR5_HUMAN (1-103): 2.92e-14: 74.3: 13.76
+	Hs
		983585 SMUF1_HUMAN (4280-4794): 2.43e-160: 519: 19.71		GBB1_HUMAN (117-339): 7.72e-23: 98.9: 12.41
+	Hs
		1341146 SMUF1_HUMAN (4280-4794): 2.43e-160: 519: 19.71		WDR36_HUMAN (18-259): 8.07e-18: 86.4: 17.00
+	Hs
		1280389 HUWE1_HUMAN (4365-4788): 3.25e-118: 426: 24.00		FBXW7_HUMAN (1-149): 1.68e-20: 94.4: 7.38
+	Hs
		1204525 HERC4_HUMAN (678-893): 7.13e-37: 156: 20.91		A16L1_HUMAN (65-330): 1.23e-16: 82.9: 15.39
+	Hs
		1138968 HERC3_HUMAN (678-893): 8.24e-34: 146: 20.00		A16L1_HUMAN (65-330): 1.23e-16: 82.9: 15.39
+	Hs
		1153173 HERC1_HUMAN (4212-4440): 3.6e-18: 95.6: 15.09		A16L1_HUMAN (65-330): 1.23e-16: 82.9: 15.39
+	Hs
		1380237 HERC5_HUMAN (424-597): 6.75e-11: 71.2: 26.56		FBXW7_HUMAN (1-149): 1.68e-20: 94.4: 7.38
+	Hs
		1212562 HECD3_HUMAN (2779-2907): 2.16e-12: 75.9: 36.84		A16L1_HUMAN (65-330): 1.23e-16: 82.9: 15.39
+	Hs
		1227010 HERC6_HUMAN (4464-4786): 1.08e-11: 73.9: 26.89		A16L1_HUMAN (65-330): 1.23e-16: 82.9: 15.39