Protein: HERC3
Probable E3 ubiquitin-protein ligase HERC3 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 3) (HECT-type E3 ubiquitin transferase HERC3)

Gene: HERC3
Organism: Homo sapiens
Interactions: 67
UniProt ID: Q15034

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0016567 - protein ubiquitination
GO:0031410 - cytoplasmic vesicle
GO:0061630 - ubiquitin protein ligase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

995961

UB2L3
Ubiquitin-conjugating enzyme E2 L3

3

20

Small-scale

0.845

High

1138987

UBQL1
Ubiquilin-1

2

17

Small-scale

0.776

High

1138985

UBQL2
Ubiquilin-2

1

16

Small-scale

0.740

High

74079

POTEC
POTE ankyrin domain family member C

2

8

High-throughput

0.726

High

1138972

HERC6
Probable E3 ubiquitin-protein ligase HERC6

1

17

Small-scale

0.665

High

508000

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

Small-scale

0.647

High

906669

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

20

Small-scale

0.647

High

1138976

NUDC2
NudC domain-containing protein 2

2

2

High-throughput

0.628

High

342876

HERC2
E3 ubiquitin-protein ligase HERC2

1

16

High-throughput

0.618

High

425510

ISG15
Ubiquitin-like protein ISG15

1

20

Small-scale

0.618

High

987359

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

15

Small-scale

0.618

High

978537

RL23A
Large ribosomal subunit protein uL23

1

2

Small-scale

0.609

High

184060

ACOX3
Peroxisomal acyl-coenzyme A oxidase 3

2

3

High-throughput

0.574

High

1043859

KCNC4
Voltage-gated potassium channel KCNC4

2

3

High-throughput

0.574

High

1138988

CP8B1
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase

2

1

High-throughput

0.574

High

703595

MK01
Mitogen-activated protein kinase 1

1

2

Small-scale

0.561

High

1138989

FBW1A
F-box/WD repeat-containing protein 1A

1

9

Small-scale

0.561

High

1138980

TTLL2
Probable tubulin polyglutamylase TTLL2

2

1

High-throughput

0.558

High

1138984

CP39A
24-hydroxycholesterol 7-alpha-hydroxylase

2

1

High-throughput

0.558

High

788493

DHB3
17-beta-hydroxysteroid dehydrogenase type 3

2

4

High-throughput

0.558

High

1010465

EREP3
Protein ENTREP3

2

16

High-throughput

0.558

High

1138965

DCST1
E3 ubiquitin-protein ligase DCST1

1

0

High-throughput

0.513

High

1138982

IF5A2
Eukaryotic translation initiation factor 5A-2

1

1

Small-scale

0.512

High

1138967

H37
Histone H3-7

2

4

High-throughput

0.504

High

1006414

SRPK2
SRSF protein kinase 2

1

15

High-throughput

0.501

High

628357

CD33
Myeloid cell surface antigen CD33

1

3

High-throughput

0.494

High

1138969

AWAT2
Acyl-CoA wax alcohol acyltransferase 2

1

2

High-throughput

0.489

High

1138970

PCAT2
Lysophosphatidylcholine acyltransferase 2

1

6

High-throughput

0.489

High

1138971

DSG4
Desmoglein-4

1

2

High-throughput

0.489

High

1138975

OR6M1
Olfactory receptor 6M1

1

3

High-throughput

0.489

High

1138981

ORNT2
Mitochondrial ornithine transporter 2

1

6

High-throughput

0.489

High

1138983

RXFP1
Relaxin receptor 1

1

4

High-throughput

0.489

High

648163

NDKB
Nucleoside diphosphate kinase B

1

3

Small-scale

0.481

High

1121216

TRI14
Tripartite motif-containing protein 14

1

5

High-throughput

0.481

High

177683

SMAD7
Mothers against decapentaplegic homolog 7

1

20

Small-scale

0.479

High

330980

KI20A
Kinesin-like protein KIF20A

1

11

High-throughput

0.479

High

413859

P53
Cellular tumor antigen p53

1

17

Small-scale

0.479

High

681649

PSA4
Proteasome subunit alpha type-4

1

7

Small-scale

0.479

High

778685

PRS7
26S proteasome regulatory subunit 7

1

6

Small-scale

0.479

High

968926

PRS8
26S proteasome regulatory subunit 8

1

9

Small-scale

0.479

High

1045307

TF65
Transcription factor p65

1

3

Small-scale

0.479

High

1138974

RCBT1
RCC1 and BTB domain-containing protein 1

1

17

High-throughput

0.479

High

1138986

FBW1B
F-box/WD repeat-containing protein 11

1

9

High-throughput

0.479

High

405462

KITH
Thymidine kinase, cytosolic

1

1

High-throughput

0.464

High

292490

RHBL1
Rhomboid-related protein 1

1

2

High-throughput

0.437

High

606065

KCNA6
Potassium voltage-gated channel subfamily A member 6

1

3

High-throughput

0.437

High

838937

RHG25
Rho GTPase-activating protein 25

1

9

High-throughput

0.437

High

851324

PRS6B
26S proteasome regulatory subunit 6B

1

7

Small-scale

0.437

High

933643

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

6

Small-scale

0.437

High

1097989

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

3

Small-scale

0.437

High

1138962

EREP1
Endosomal transmembrane epsin interactor 1

1

16

High-throughput

0.437

High

1138963

MOGT2
2-acylglycerol O-acyltransferase 2

1

2

High-throughput

0.437

High

1138966

TMTC4
Protein O-mannosyl-transferase TMTC4

1

7

High-throughput

0.437

High

1138977

RDH5
Retinol dehydrogenase 5

1

3

High-throughput

0.437

High

870444

SC6A9
Sodium- and chloride-dependent glycine transporter 1

1

4

High-throughput

0.407

High

1031787

LAT1
Large neutral amino acids transporter small subunit 1

1

2

High-throughput

0.407

High

1138964

SL9C1
Solute carrier family 9 member C1

1

6

High-throughput

0.407

High

1138968

A16L1
Autophagy-related protein 16-1

1

8

High-throughput

0.407

High

1138978

FUCT1
GDP-fucose transporter 1

1

1

High-throughput

0.407

High

1138979

S26A8
Testis anion transporter 1

1

1

High-throughput

0.407

High

1138990

S27A6
Long-chain fatty acid transport protein 6

1

3

High-throughput

0.407

High

1138991

GUAD
Guanine deaminase

2

0

High-throughput

0.328

High

142213

CCL22
C-C motif chemokine 22

1

0

High-throughput

0.282

High

935379

IOD3
Thyroxine 5-deiodinase

1

0

High-throughput

0.279

Low

1138973

I17RC
Interleukin-17 receptor C

1

0

High-throughput

0.279

Low

1071244

TMM62
Transmembrane protein 62

1

0

High-throughput

0.249

Low

62527

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025