Protein: HERC4
Probable E3 ubiquitin-protein ligase HERC4 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 4) (HECT-type E3 ubiquitin transferase HERC4)

Gene: HERC4
Organism: Homo sapiens
Interactions: 61
UniProt ID: Q5GLZ8

Gene Ontology (top 5):
GO:0001650 - fibrillar center
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0007283 - spermatogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

508091

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

20

Small-scale

0.778

High

982200

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

20

Small-scale

0.778

High

995968

UB2L3
Ubiquitin-conjugating enzyme E2 L3

2

20

Small-scale

0.778

High

1204524

HERC4
Probable E3 ubiquitin-protein ligase HERC4

2

16

Small-scale

0.778

High

347743

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.691

High

1204534

UB2J2
Ubiquitin-conjugating enzyme E2 J2

1

20

Small-scale

0.647

High

1204538

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

20

Small-scale

0.647

High

335688

MOCS3
Adenylyltransferase and sulfurtransferase MOCS3

2

11

High-throughput

0.628

High

1204527

KLH10
Kelch-like protein 10

2

2

High-throughput

0.628

High

1204531

NLRX1
NLR family member X1

2

6

High-throughput

0.628

High

1204544

LOXE3
Hydroperoxide isomerase ALOXE3

2

1

High-throughput

0.628

High

1204550

WRP73
WD repeat-containing protein WRAP73

2

5

High-throughput

0.628

High

1204542

FDXA1
Ferredoxin-fold anticodon-binding domain-containing protein 1

2

1

High-throughput

0.621

High

1200308

ANR39
Ankyrin repeat domain-containing protein 39

1

7

High-throughput

0.618

High

425535

ISG15
Ubiquitin-like protein ISG15

1

20

Small-scale

0.618

High

1204533

HERC6
Probable E3 ubiquitin-protein ligase HERC6

1

16

Small-scale

0.618

High

442738

RB
Retinoblastoma-associated protein

1

1

High-throughput

0.536

High

984146

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

4

High-throughput

0.536

High

1093244

FLII
Protein flightless-1 homolog

1

4

High-throughput

0.536

High

1187255

WDR72
WD repeat-containing protein 72

1

14

High-throughput

0.536

High

1204540

DNJC7
DnaJ homolog subfamily C member 7

1

13

High-throughput

0.536

High

1204545

NUF2
Kinetochore protein Nuf2

1

7

High-throughput

0.536

High

1204526

Q6ICH2
single-stranded DNA cytosine deaminase

2

5

High-throughput

0.533

High

284323

GEMI
Geminin

1

0

High-throughput

0.513

High

1150537

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

High-throughput

0.513

High

1204537

MAFA
Transcription factor MafA

1

8

Small-scale

0.512

High

1010476

EREP3
Protein ENTREP3

1

18

High-throughput

0.489

High

1176982

INF2
Inverted formin-2

1

5

High-throughput

0.489

High

1204464

ARSH
Arylsulfatase H

1

2

High-throughput

0.489

High

1204529

ABH15
Protein ABHD15

1

1

High-throughput

0.489

High

1204551

ZN215
Zinc finger protein 215

1

2

High-throughput

0.489

High

282187

MAF
Transcription factor Maf

1

1

Small-scale

0.479

High

412048

NTRK1
High affinity nerve growth factor receptor

1

18

High-throughput

0.479

High

442948

PRGR
Progesterone receptor

1

16

Small-scale

0.479

High

461568

HS90A
Heat shock protein HSP 90-alpha

1

15

High-throughput

0.479

High

468460

HS90B
Heat shock protein HSP 90-beta

1

15

High-throughput

0.479

High

830861

CCNF
Cyclin-F

1

10

High-throughput

0.479

High

1004660

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.479

High

1106568

SMAD4
Mothers against decapentaplegic homolog 4

1

20

High-throughput

0.479

High

1204530

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.479

High

1204532

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1204547

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

10

High-throughput

0.479

High

1204549

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

3

Small-scale

0.479

High

64874

RCCD1
RCC1 domain-containing protein 1

1

17

High-throughput

0.445

High

231588

PRKY
Putative serine/threonine-protein kinase PRKY

1

20

High-throughput

0.445

High

1204525

A16L1
Autophagy-related protein 16-1

1

7

High-throughput

0.445

High

1204539

ABC3D
DNA dC->dU-editing enzyme APOBEC-3D

1

5

High-throughput

0.445

High

1204548

TKTL2
Transketolase-like protein 2

1

5

High-throughput

0.445

High

768359

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

1204535

PLD5
Inactive phospholipase D5

1

1

High-throughput

0.437

High

1204541

SMO
Protein smoothened

1

3

Small-scale

0.437

High

73409

B2CML4
single-stranded DNA cytosine deaminase

1

5

High-throughput

0.407

High

1204536

TSYL6
Testis-specific Y-encoded-like protein 6

1

5

High-throughput

0.407

High

1204543

TSSK1
Testis-specific serine/threonine-protein kinase 1

1

15

High-throughput

0.407

High

1204546

LRC27
Leucine-rich repeat-containing protein 27

1

9

High-throughput

0.407

High

1204552

S27A6
Long-chain fatty acid transport protein 6

1

3

High-throughput

0.407

High

1204528

CA094
Uncharacterized protein C1orf94

2

0

High-throughput

0.328

High

168859

PLD2
Phospholipase D2

2

0

High-throughput

0.318

High

1204249

CAR16
Caspase recruitment domain-containing protein 16

1

0

High-throughput

0.279

Low

873915

INAR2
Interferon alpha/beta receptor 2

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025