Protein: HERC1
Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619)

Gene: HERC1
Organism: Homo sapiens
Interactions: 148
UniProt ID: Q15751

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005737 - cytoplasm
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1153192

WDFY3
WD repeat and FYVE domain-containing protein 3

2

10

High-throughput

0.811

High

508027

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

20

High-throughput

0.778

High

947468

RAB15
Ras-related protein Rab-15

1

3

High-throughput

0.691

High

1153235

AKT3
RAC-gamma serine/threonine-protein kinase

1

20

High-throughput

0.691

High

1153202

SSH3
Protein phosphatase Slingshot homolog 3

3

2

High-throughput

0.667

High

1153210

FBXW5
F-box/WD repeat-containing protein 5

1

0

High-throughput

0.656

High

957083

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

20

Small-scale

0.647

High

982192

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

20

High-throughput

0.647

High

995963

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

20

High-throughput

0.647

High

1153156

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

15

Small-scale

0.647

High

1153158

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

20

Small-scale

0.647

High

1153208

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

16

High-throughput

0.647

High

1153166

TFDP3
Transcription factor Dp family member 3

3

0

High-throughput

0.638

High

876874

KC1A
Casein kinase I isoform alpha

2

3

High-throughput

0.628

High

881121

FMO5
Flavin-containing monooxygenase 5

2

1

High-throughput

0.628

High

1153170

IFT1B
Protein IFIT1 homolog B

2

12

High-throughput

0.628

High

1153177

TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

2

13

High-throughput

0.628

High

1153205

RPGF5
Rap guanine nucleotide exchange factor 5

2

4

High-throughput

0.628

High

1153227

SMOX
Spermine oxidase

2

1

High-throughput

0.628

High

1153229

RABX5
Rab5 GDP/GTP exchange factor

2

3

High-throughput

0.628

High

1153189

DHX40
Probable ATP-dependent RNA helicase DHX40

1

8

High-throughput

0.618

High

157426

CTRO
Citron Rho-interacting kinase

1

18

High-throughput

0.618

High

241785

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.618

High

245949

KIF1B
Kinesin-like protein KIF1B

1

9

High-throughput

0.618

High

342886

HERC2
E3 ubiquitin-protein ligase HERC2

1

16

High-throughput

0.618

High

946784

H2B1D
Histone H2B type 1-D

1

12

High-throughput

0.618

High

978030

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

1014899

ARF1
ADP-ribosylation factor 1

1

7

Small-scale

0.618

High

1153173

A16L1
Autophagy-related protein 16-1

1

9

High-throughput

0.618

High

1153179

TRI67
Tripartite motif-containing protein 67

1

19

High-throughput

0.618

High

1153218

H2B1L
Histone H2B type 1-L

1

11

High-throughput

0.618

High

1153225

ANLN
Anillin

1

2

High-throughput

0.618

High

1153232

UBP18
Ubl carboxyl-terminal hydrolase 18

1

16

High-throughput

0.618

High

1153234

DYN3
Dynamin-3

1

3

High-throughput

0.618

High

1153237

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

10

Small-scale

0.618

High

1116802

RAPSN
43 kDa receptor-associated protein of the synapse

2

5

High-throughput

0.611

High

717091

ECHM
Enoyl-CoA hydratase, mitochondrial

3

11

High-throughput

0.609

High

1153184

MORC1
MORC family CW-type zinc finger protein 1

3

2

High-throughput

0.609

High

335660

GCNT3
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3

2

0

High-throughput

0.602

High

1153186

VPS36
Vacuolar protein-sorting-associated protein 36

2

0

High-throughput

0.602

High

1153203

TP4AP
Short transient receptor potential channel 4-associated protein

2

0

High-throughput

0.602

High

1049322

1433F
14-3-3 protein eta

2

20

High-throughput

0.601

High

70894

ZBBX
Zinc finger B-box domain-containing protein 1

2

1

High-throughput

0.574

High

1153191

DRC2
Dynein regulatory complex subunit 2

2

1

High-throughput

0.574

High

1153195

ZN610
Zinc finger protein 610

2

1

High-throughput

0.574

High

1153198

ZN555
Zinc finger protein 555

2

2

High-throughput

0.574

High

1153230

ZN223
Zinc finger protein 223

2

2

High-throughput

0.574

High

1153238

NGN3
Neurogenin-3

2

4

High-throughput

0.574

High

1026053

CLH1
Clathrin heavy chain 1

1

7

Small-scale

0.573

High

351277

TTLL1
Polyglutamylase complex subunit TTLL1

2

1

High-throughput

0.571

High

400889

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

Small-scale

0.561

High

873089

SOX9
Transcription factor SOX-9

1

15

Small-scale

0.561

High

341061

DIRA3
GTP-binding protein Di-Ras3

1

5

High-throughput

0.553

High

165714

PPE1
Serine/threonine-protein phosphatase with EF-hands 1

1

7

High-throughput

0.536

High

755932

MCM5
DNA replication licensing factor MCM5

1

10

High-throughput

0.536

High

1093234

FLII
Protein flightless-1 homolog

1

7

High-throughput

0.536

High

1153167

SPDYC
Speedy protein C

1

2

High-throughput

0.536

High

1153178

TLCD5
TLC domain-containing protein 5

1

2

High-throughput

0.536

High

1153185

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

5

High-throughput

0.536

High

1153211

EFMT3
EEF1A lysine methyltransferase 3

1

7

High-throughput

0.536

High

1153212

PABP5
Polyadenylate-binding protein 5

1

11

High-throughput

0.536

High

1153220

AFG2B
ATPase family gene 2 protein homolog B

1

6

High-throughput

0.536

High

1153222

UBXN6
UBX domain-containing protein 6

1

4

High-throughput

0.536

High

1153223

SENP3
Sentrin-specific protease 3

1

6

High-throughput

0.536

High

1153228

KLH14
Kelch-like protein 14

1

3

High-throughput

0.536

High

1153233

SNX6
Sorting nexin-6

1

4

High-throughput

0.536

High

573114

KPYM
Pyruvate kinase PKM

1

7

Small-scale

0.527

High

698689

CALX
Calnexin

1

7

High-throughput

0.515

High

1153172

ANR22
Ankyrin repeat domain-containing protein 22

1

13

High-throughput

0.514

High

208047

TTI1
TELO2-interacting protein 1 homolog

1

0

High-throughput

0.513

High

635868

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

High-throughput

0.513

High

1153159

UPP1
Uridine phosphorylase 1

1

0

High-throughput

0.513

High

1153168

ATAT
Alpha-tubulin N-acetyltransferase 1

1

0

High-throughput

0.513

High

1153171

IKBP1
Interleukin-1 receptor-associated kinase 1-binding protein 1

1

0

High-throughput

0.513

High

1153197

CC020
Uncharacterized protein C3orf20

1

0

High-throughput

0.513

High

1153204

CHAC2
Glutathione-specific gamma-glutamylcyclotransferase 2

1

0

High-throughput

0.513

High

362301

ABL1
Tyrosine-protein kinase ABL1

1

15

Small-scale

0.501

High

517474

GLI2
Zinc finger protein GLI2

1

7

High-throughput

0.500

High

426504

HMGN2
Non-histone chromosomal protein HMG-17

1

0

High-throughput

0.493

High

48142

IFT56
Intraflagellar transport protein 56

1

1

High-throughput

0.489

High

66791

C2C4B
C2 calcium-dependent domain-containing protein 4B

1

1

High-throughput

0.489

High

274836

PX11A
Peroxisomal membrane protein 11A

1

1

High-throughput

0.489

High

913724

ZN136
Zinc finger protein 136

1

3

High-throughput

0.489

High

1153162

INF2
Inverted formin-2

1

6

High-throughput

0.489

High

1153180

ATS13
A disintegrin and metalloproteinase with thrombospondin motifs 13

1

1

High-throughput

0.489

High

1153194

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

3

High-throughput

0.489

High

1153196

C2C4A
C2 calcium-dependent domain-containing protein 4A

1

1

High-throughput

0.489

High

1153201

ZN563
Zinc finger protein 563

1

3

High-throughput

0.489

High

1153216

PPM1M
Protein phosphatase 1M

1

3

High-throughput

0.489

High

1153217

NPAS1
Neuronal PAS domain-containing protein 1

1

6

High-throughput

0.489

High

1153236

RCL1
RNA 3'-terminal phosphate cyclase-like protein

1

2

High-throughput

0.489

High

73703

R10B2
Radial spoke head 10 homolog B2

1

6

High-throughput

0.479

High

138128

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

18

High-throughput

0.479

High

163940

NDC80
Kinetochore protein NDC80 homolog

1

5

High-throughput

0.479

High

223077

PRC1
Protein regulator of cytokinesis 1

1

2

High-throughput

0.479

High

331000

KI20A
Kinesin-like protein KIF20A

1

16

High-throughput

0.479

High

363333

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.479

High

611139

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

7

High-throughput

0.479

High

693760

RL10
Large ribosomal subunit protein uL16

1

3

High-throughput

0.479

High

766206

NOS2
Nitric oxide synthase, inducible

1

2

High-throughput

0.479

High

799148

BRCA1
Breast cancer type 1 susceptibility protein

1

9

High-throughput

0.479

High

890833

TSC2
Tuberin

1

7

Small-scale

0.479

High

946114

MLF1
Myeloid leukemia factor 1

1

2

High-throughput

0.479

High

1067373

EP300
Histone acetyltransferase p300

1

10

Small-scale

0.479

High

1113194

CUL3
Cullin-3

1

15

High-throughput

0.479

High

1140328

KIF14
Kinesin-like protein KIF14

1

11

High-throughput

0.479

High

1153164

RHG29
Rho GTPase-activating protein 29

1

9

High-throughput

0.479

High

1153187

DYR2
Dihydrofolate reductase 2, mitochondrial

1

3

High-throughput

0.479

High

1153207

FGF11
Fibroblast growth factor 11

1

5

High-throughput

0.479

High

1153226

PXMP2
Peroxisomal membrane protein 2

1

2

High-throughput

0.479

High

130839

DFFA
DNA fragmentation factor subunit alpha

1

0

High-throughput

0.458

High

516762

SCHI1
Schwannomin-interacting protein 1

1

0

High-throughput

0.458

High

785831

8ODP
Oxidized purine nucleoside triphosphate hydrolase

1

0

Small-scale

0.458

High

1153200

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

253158

MOT2
Monocarboxylate transporter 2

1

6

High-throughput

0.445

High

1153175

S27A4
Long-chain fatty acid transport protein 4

1

10

High-throughput

0.445

High

1153176

S27A1
Long-chain fatty acid transport protein 1

1

10

High-throughput

0.445

High

1153182

RABEK
Rab9 effector protein with kelch motifs

1

7

High-throughput

0.445

High

1153199

ZNT7
Zinc transporter 7

1

6

High-throughput

0.445

High

1153213

AURKB
Aurora kinase B

1

19

High-throughput

0.445

High

1153215

PIWL1
Piwi-like protein 1

1

2

High-throughput

0.445

High

1153231

AKP8L
A-kinase anchor protein 8-like

1

3

High-throughput

0.445

High

429953

JUN
Transcription factor Jun

1

7

High-throughput

0.437

High

588793

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.437

High

695558

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.437

High

1153206

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

2

High-throughput

0.437

High

1153224

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

2

High-throughput

0.437

High

1153157

BAK
Bcl-2 homologous antagonist/killer

1

5

Small-scale

0.408

High

337735

SGPL1
Sphingosine-1-phosphate lyase 1

1

1

High-throughput

0.407

High

344206

PTBP3
Polypyrimidine tract-binding protein 3

1

10

High-throughput

0.407

High

1153174

TBC3G
TBC1 domain family member 3G

1

3

High-throughput

0.407

High

1153183

TTC6
Tetratricopeptide repeat protein 6

1

10

High-throughput

0.407

High

1153160

TIGD6
Tigger transposable element-derived protein 6

2

0

High-throughput

0.328

High

1153181

ZN571
Zinc finger protein 571

2

0

High-throughput

0.328

High

1153193

CA087
Uncharacterized protein C1orf87

2

0

High-throughput

0.328

High

289775

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.279

Low

1153163

CMAP2
Ciliary microtubule-associated protein 2

1

0

High-throughput

0.279

Low

1153165

VWA2
von Willebrand factor A domain-containing protein 2

1

0

High-throughput

0.279

Low

1153169

F120S
Uncharacterized protein FAM120AOS

1

0

High-throughput

0.279

Low

1153188

FXRD2
FAD-dependent oxidoreductase domain-containing protein 2

1

0

High-throughput

0.279

Low

1153190

IQCF2
IQ domain-containing protein F2

1

0

High-throughput

0.279

Low

1153209

UCN3
Urocortin-3

1

0

High-throughput

0.279

Low

1153214

HES6
Transcription cofactor HES-6

1

0

High-throughput

0.279

Low

1153219

GDAH
Guanidino acid hydrolase, mitochondrial

1

0

High-throughput

0.279

Low

1153221

FND11
Fibronectin type III domain-containing protein 11

1

0

High-throughput

0.279

Low

880013

DNSL1
Deoxyribonuclease-1-like 1

1

0

High-throughput

0.232

Low

1153161

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025