HitPredict - High confidence protein-protein interactions

Interactor 1: CO3 (P01024)
Complement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
Gene: C3

Interactor 2: CO3 (P01024)
Complement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
Gene: C3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	21285368
Identification Methods	x-ray crystallography
Interaction Type	physical association

Property	Details
Interacting Pfam domains	A2M~A2M_BRD, A2M~A2M_recep, A2M~MG2, A2M~MG3, A2M_BRD~A2M_BRD, A2M_BRD~MG1, A2M_BRD~MG2, A2M_BRD~MG3, A2M_BRD~MG4, A2M_recep~A2M_recep, A2M_recep~ANATO, A2M_recep~MG3, A2M_recep~NTR, A2M_recep~TED_complement, ANATO~ANATO, MG1~MG2, MG1~TED_complement, MG2~MG2, MG2~MG3, MG2~TED_complement and 6 others more... MG3~MG3, MG3~MG4, MG3~TED_complement, MG4~MG4, MG4~TED_complement, TED_complement~TED_complement
Common GO terms	GO:0001798 - positive regulation of type IIa hypersensitivity GO:0001934 - positive regulation of protein phosphorylation GO:0001970 - positive regulation of activation of membrane attack complex GO:0002430 - complement receptor mediated signaling pathway GO:0004866 - endopeptidase inhibitor activity and 36 others more... GO:0005102 - signaling receptor binding GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0005788 - endoplasmic reticulum lumen GO:0005886 - plasma membrane GO:0006631 - fatty acid metabolic process GO:0006954 - inflammatory response GO:0006955 - immune response GO:0006956 - complement activation GO:0006957 - complement activation, alternative pathway GO:0006958 - complement activation, classical pathway GO:0007165 - signal transduction GO:0007186 - G protein-coupled receptor signaling pathway GO:0009617 - response to bacterium GO:0009986 - cell surface GO:0010575 - positive regulation of vascular endothelial growth factor production GO:0010828 - positive regulation of glucose transmembrane transport GO:0010866 - regulation of triglyceride biosynthetic process GO:0010884 - positive regulation of lipid storage GO:0016322 - neuron remodeling GO:0031715 - C5L2 anaphylatoxin chemotactic receptor binding GO:0032991 - protein-containing complex GO:0034774 - secretory granule lumen GO:0035578 - azurophil granule lumen GO:0035846 - oviduct epithelium development GO:0045745 - positive regulation of G protein-coupled receptor signaling pathway GO:0045766 - positive regulation of angiogenesis GO:0048260 - positive regulation of receptor-mediated endocytosis GO:0060100 - positive regulation of phagocytosis, engulfment GO:0070062 - extracellular exosome GO:0072562 - blood microparticle GO:0097242 - amyloid-beta clearance GO:0097278 - complement-dependent cytotoxicity GO:0150062 - complement-mediated synapse pruning GO:0150064 - vertebrate eye-specific patterning GO:2000427 - positive regulation of apoptotic cell clearance
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1	1663
Hs

1	1663

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Last updated: 15 Jul 2024