HitPredict

Interactor 1: CO3 (P01024)
Complement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
Gene: C3

Interactor 2: ITAX (P20702)
Integrin alpha-X (CD11 antigen-like family member C) (Leu M5) (Leukocyte adhesion glycoprotein p150,95 alpha chain) (Leukocyte adhesion receptor p150,95) (CD antigen CD11c)
Gene: ITGAX

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	4062888, 12554829
Identification Methods	pull down, surface plasmon resonance
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	NTR~VWA, TED_complement~VWA
Common GO terms	GO:0005886 - plasma membrane GO:0009986 - cell surface GO:0045766 - positive regulation of angiogenesis
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1663 Hs			1 1163
+	Hs
		344628 CO3_HUMAN (1-1663): 0: 2219: 100.00		ITAM_HUMAN (8-1151): 0: 1179: 61.06
+	Hs
		341566 CO3_HUMAN (1-1663): 0: 2219: 100.00		CFAB_HUMAN (15-375): 8.07e-57: 213: 16.27
+	Hs
		126322 CO3_HUMAN (1-1663): 0: 2219: 100.00		MATN2_HUMAN (144-367): 9.27e-42: 168: 22.03
+	Hs
		416130 CO4B_HUMAN (16-1661): 0: 1625: 28.37		CO2_HUMAN (17-369): 3.71e-60: 223: 16.91
+	Hs
		416129 CO4A_HUMAN (16-1661): 0: 1624: 28.20		CO2_HUMAN (17-369): 3.71e-60: 223: 16.91
+	Hs
		126347 CO4A_HUMAN (16-1661): 0: 1624: 28.20		MATN2_HUMAN (144-367): 9.27e-42: 168: 22.03
+	Hs
		126321 A2MG_HUMAN (19-1498): 0: 1369: 23.02		MATN2_HUMAN (144-367): 9.27e-42: 168: 22.03