HitPredict

Interactor 1: FOS (P01100)
Protein c-Fos (Cellular oncogene fos) (Fos proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 7) (Proto-oncogene c-Fos) (Transcription factor AP-1 subunit c-Fos)
Gene: FOS

Interactor 2: JUN (P05412)
Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39)
Gene: JUN

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.996

The method score is based on:

Property Details
Experiments 25609649, 9160889, 7816143, 10488148, 8440710, 31182485, 8380166, 34671206, 36629882, 11431474, 20936779, 20410304, 21675959, 16055710, 11090181, 15319445, 23661758, 15718494, 17440114, 20195357 and 25 others

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Identification Methods affinity chromatography technology, pull down, x-ray crystallography, two hybrid, protein complementation assay, fluorescent resonance energy transfer, proximity labelling technology, bimolecular fluorescence complementation, anti tag coimmunoprecipitation, peptide array and 7 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains bZIP_1~bZIP_1
Common GO terms GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
and 17 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 380
Hs

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Last updated: 15 Jul 2024