HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: PLAK (P14923)
Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3)
Gene: JUP

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	29467282, 35013218, 36424410
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0140297 - DNA-binding transcription factor binding
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 745
+	Hs
		346075 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38
+	Mm
		348419 MYC_MOUSE (1-454): 4.33e-119: 357: 89.01		CTNB1_MOUSE (1-731): 2.79e-173: 518: 67.38
+	Hs
		378980 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		PLAK_HUMAN (1-745): 0: 551: 100.00
+	Hs
		239014 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		CTND1_HUMAN (203-728): 3.14e-90: 305: 16.25
+	Mm
		970124 MITF_MOUSE (155-450): 3.21e-31: 127: 15.11		CTNB1_MOUSE (1-731): 2.79e-173: 518: 67.38
+	Hs
		252908 MITF_HUMAN (155-450): 1.47e-29: 123: 14.47		CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38
+	Hs
		134819 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		IMA3_HUMAN (228-670): 2.7e-65: 227: 16.01
+	Hs
		131358 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		IMA4_HUMAN (228-670): 5.34e-64: 224: 15.79
+	Hs
		346287 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		IMA5_HUMAN (231-685): 6.58e-61: 215: 15.06
+	Hs
		346286 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		IMA1_HUMAN (270-664): 6.19e-48: 179: 14.32
+	Hs
		168608 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		IMA6_HUMAN (273-659): 3.11e-41: 160: 13.95
+	Hs
		119747 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		ARVC_HUMAN (203-647): 2.38e-15: 82.5: 18.54
+	Hs
		131364 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		IMA4_HUMAN (228-670): 5.34e-64: 224: 15.79
+	Hs
		379151 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		IMA1_HUMAN (270-664): 6.19e-48: 179: 14.32
+	Hs
		168610 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		IMA6_HUMAN (273-659): 3.11e-41: 160: 13.95