Protein: PPIP1
Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP)

Gene: PPIP1, PSTPIP1
Organism: Homo sapiens
Interactions: 116
UniProt ID: O43586

Gene Ontology (top 5):
GO:0001931 - uropod
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005856 - cytoskeleton
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

220723

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

2

15

Small-scale

0.828

High

220779

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

7

High-throughput

0.783

High

220754

DYN2
Dynamin-2

2

20

Small-scale

0.768

High

220727

ABL1
Tyrosine-protein kinase ABL1

1

10

Small-scale

0.740

High

220805

SH24A
SH2 domain-containing protein 4A

1

6

High-throughput

0.740

High

220765

PTN12
Tyrosine-protein phosphatase non-receptor type 12

6

15

Small-scale

0.735

High

220799

PTN18
Tyrosine-protein phosphatase non-receptor type 18

3

15

Small-scale

0.682

High

220726

TULP3
Tubby-related protein 3

3

1

High-throughput

0.675

High

220824

LSM4
U6 snRNA-associated Sm-like protein LSm4

3

1

High-throughput

0.675

High

220747

WASP
Actin nucleation-promoting factor WAS

3

20

Small-scale

0.664

High

194770

MEFV
Pyrin

3

2

Small-scale

0.660

High

220821

PTN22
Tyrosine-protein phosphatase non-receptor type 22

2

14

Small-scale

0.652

High

220815

ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

1

6

Small-scale

0.647

High

220772

RTP5
Receptor-transporting protein 5

3

0

High-throughput

0.646

High

220825

PCDBE
Protocadherin beta-14

3

0

High-throughput

0.646

High

220790

UBE2W
Ubiquitin-conjugating enzyme E2 W

2

0

High-throughput

0.613

High

220751

TNFL6
Tumor necrosis factor ligand superfamily member 6

2

8

Small-scale

0.612

High

220731

CD2
T-cell surface antigen CD2

2

0

Small-scale

0.610

High

220769

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

2

2

High-throughput

0.606

High

220774

RNPS1
RNA-binding protein with serine-rich domain 1

2

1

High-throughput

0.606

High

220792

MCRS1
Microspherule protein 1

2

1

High-throughput

0.606

High

220813

ZN580
Zinc finger protein 580

2

1

High-throughput

0.606

High

220725

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

220728

MOS
Proto-oncogene serine/threonine-protein kinase mos

2

0

High-throughput

0.580

High

220738

TPH1
Tryptophan 5-hydroxylase 1

2

0

High-throughput

0.580

High

220743

RL9
Large ribosomal subunit protein uL6

2

0

High-throughput

0.580

High

220764

HHEX
Hematopoietically-expressed homeobox protein HHEX

2

0

High-throughput

0.580

High

220768

NCBP1
Nuclear cap-binding protein subunit 1

2

0

High-throughput

0.580

High

220776

T10IP
Testis-specific protein 10-interacting protein

2

0

High-throughput

0.580

High

220797

PNKP
Bifunctional polynucleotide phosphatase/kinase

2

0

High-throughput

0.580

High

220803

HPLN2
Hyaluronan and proteoglycan link protein 2

2

0

High-throughput

0.580

High

140066

SDCB1
Syntenin-1

1

3

High-throughput

0.573

High

220724

BUB3
Mitotic checkpoint protein BUB3

1

1

High-throughput

0.573

High

220819

T3JAM
TRAF3-interacting JNK-activating modulator

1

7

High-throughput

0.573

High

220775

C19L2
CWF19-like protein 2

2

2

High-throughput

0.553

High

220793

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

2

1

High-throughput

0.553

High

220802

SCNM1
Sodium channel modifier 1

2

1

High-throughput

0.553

High

220823

ZN175
Zinc finger protein 175

1

0

High-throughput

0.549

High

220741

RXRB
Retinoic acid receptor RXR-beta

1

3

High-throughput

0.541

High

220816

ASC
Apoptosis-associated speck-like protein containing a CARD

1

2

Small-scale

0.536

High

220818

SPG7
Mitochondrial inner membrane m-AAA protease component paraplegin

1

2

High-throughput

0.523

High

181033

AXIN1
Axin-1

1

0

High-throughput

0.518

High

220758

RL23A
Large ribosomal subunit protein uL23

1

2

High-throughput

0.515

High

220778

Q53ZZ1
Tumor necrosis factor ligand superfamily member 6

1

8

Small-scale

0.515

High

220783

5MP2
eIF5-mimic protein 2

1

1

High-throughput

0.515

High

220820

RUVB1
RuvB-like 1

1

1

High-throughput

0.515

High

220826

5MP1
eIF5-mimic protein 1

1

1

High-throughput

0.515

High

220767

ECHP
Peroxisomal bifunctional enzyme

1

2

High-throughput

0.515

High

133609

WASL
Actin nucleation-promoting factor WASL

1

20

Small-scale

0.501

High

220740

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.493

High

220742

PUR9
Bifunctional purine biosynthesis protein ATIC

1

0

High-throughput

0.493

High

220744

FDFT
Squalene synthase

1

0

High-throughput

0.493

High

220745

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.493

High

220746

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.493

High

220750

RL29
Large ribosomal subunit protein eL29

1

0

High-throughput

0.493

High

220752

RL34
Large ribosomal subunit protein eL34

1

0

High-throughput

0.493

High

220756

RL26
Large ribosomal subunit protein uL24

1

0

High-throughput

0.493

High

220757

RL37A
Large ribosomal subunit protein eL43

1

0

High-throughput

0.493

High

220759

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.493

High

220760

RL32
Large ribosomal subunit protein eL32

1

0

High-throughput

0.493

High

220762

RL36A
Large ribosomal subunit protein eL42

1

0

High-throughput

0.493

High

220763

RL18A
Large ribosomal subunit protein eL20

1

0

High-throughput

0.493

High

220804

MED28
Mediator of RNA polymerase II transcription subunit 28

1

0

Small-scale

0.493

High

220808

DDX21
Nucleolar RNA helicase 2

1

0

High-throughput

0.493

High

220822

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.493

High

137155

EXOC5
Exocyst complex component 5

1

1

High-throughput

0.481

High

220733

CC172
Coiled-coil domain-containing protein 172

1

1

High-throughput

0.481

High

220770

MVP
Major vault protein

1

2

High-throughput

0.481

High

220780

RINT1
RAD50-interacting protein 1

1

1

High-throughput

0.481

High

220798

TTC1
Tetratricopeptide repeat protein 1

1

2

High-throughput

0.481

High

220809

TBA8
Tubulin alpha-8 chain

1

5

High-throughput

0.481

High

220810

TFP11
Tuftelin-interacting protein 11

1

1

High-throughput

0.481

High

220771

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

0

Small-scale

0.480

High

160949

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

19

Small-scale

0.479

High

219534

WIPF1
WAS/WASL-interacting protein family member 1

1

20

Small-scale

0.479

High

220732

TBB5
Tubulin beta chain

1

1

Small-scale

0.479

High

220736

DESP
Desmoplakin

1

10

High-throughput

0.479

High

220739

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

13

Small-scale

0.479

High

220753

SYCC
Cysteine--tRNA ligase, cytoplasmic

1

4

Small-scale

0.479

High

220755

ACTB
Actin, cytoplasmic 1

1

8

Small-scale

0.479

High

220761

RED1
Double-stranded RNA-specific editase 1

1

3

High-throughput

0.479

High

220773

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

220800

AKAP9
A-kinase anchor protein 9

1

7

High-throughput

0.479

High

220812

ANC2
Anaphase-promoting complex subunit 2

1

1

High-throughput

0.479

High

220814

MYH13
Myosin-13

1

2

High-throughput

0.479

High

214639

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

1

High-throughput

0.470

High

220796

FXL18
F-box/LRR-repeat protein 18

1

0

High-throughput

0.460

High

220748

RL21
Large ribosomal subunit protein eL21

1

0

High-throughput

0.458

High

220749

RL28
Large ribosomal subunit protein eL28

1

0

High-throughput

0.458

High

220801

GNL3
Guanine nucleotide-binding protein-like 3

1

0

High-throughput

0.458

High

220811

SUCO
SUN domain-containing ossification factor

1

0

High-throughput

0.458

High

220827

X5D7R7
Major vault protein

1

2

High-throughput

0.457

High

220828

X5DP17
Major vault protein isoform H

1

2

High-throughput

0.457

High

220729

SHBG
Sex hormone-binding globulin

1

1

Small-scale

0.439

High

220734

ZN688
Zinc finger protein 688

1

3

High-throughput

0.439

High

220785

NAV2
Neuron navigator 2

1

3

High-throughput

0.439

High

220788

SYCE1
Synaptonemal complex central element protein 1

1

1

High-throughput

0.439

High

220807

HM20A
High mobility group protein 20A

1

2

High-throughput

0.439

High

220787

TAF1L
Transcription initiation factor TFIID subunit 1-like

1

2

High-throughput

0.437

High

220795

KS6R
Ribosomal protein S6 kinase-related protein

1

3

High-throughput

0.437

High

220817

KMT2B
Histone-lysine N-methyltransferase 2B

1

1

High-throughput

0.437

High

3519

A0A0S2Z5X4
Zinc finger protein 688 isoform 4

1

3

High-throughput

0.417

High

220766

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

7

Small-scale

0.408

High

220789

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

4

0

High-throughput

0.370

High

220784

F90A1
Protein FAM90A1

3

0

High-throughput

0.352

High

220735

PRR35
Proline-rich protein 35

2

0

High-throughput

0.316

High

220777

ZC21C
Zinc finger C2HC domain-containing protein 1C

2

0

High-throughput

0.316

High

220786

DHX40
Probable ATP-dependent RNA helicase DHX40

2

0

High-throughput

0.316

High

220794

LIN37
Protein lin-37 homolog

2

0

High-throughput

0.316

High

220806

ZN408
Zinc finger protein 408

2

0

High-throughput

0.316

High

220737

H12
Histone H1.2

1

0

High-throughput

0.269

Low

220791

Q96D16
FBXL18 protein

1

0

High-throughput

0.268

Low

220730

7B2
Neuroendocrine protein 7B2

1

0

High-throughput

0.249

Low

220781

Q75MH1
40S ribosomal protein S26

1

0

High-throughput

0.249

Low

220782

Q76P68
Large ribosomal subunit protein uL11

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025