HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: H33 (P84243)
Histone H3.3
Gene: H3-3A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	32140074, 35013218, 21150319
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0032991 - protein-containing complex
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 136
+	Hs
		346911 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		347136 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Mm
		348417 MYC_MOUSE (1-454): 4.33e-119: 357: 89.01		H33_MOUSE (1-136): 1.12e-59: 182: 100.00
+	Hs
		379292 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		607805 USF1_HUMAN (175-453): 1.02e-39: 146: 18.40		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		607808 USF1_HUMAN (175-453): 1.02e-39: 146: 18.40		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		934954 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		952456 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		1086209 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		898102 MAX_HUMAN (354-454): 1.39e-24: 101: 32.67		H33_HUMAN (1-136): 1.12e-59: 182: 100.00