HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36976175
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~fn3, PK_Tyr_Ser-Thr~Pkinase, Pkinase~SAM_1
Common GO terms	GO:0005524 - ATP binding GO:0005925 - focal adhesion GO:0030335 - positive regulation of cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1239 Hs			1 976
+	Hs
		348128 M4K4_HUMAN (1-1239): 0: 1238: 100.00		EPHA7_HUMAN (4-974): 0: 1120: 50.15
+	Hs
		348080 M4K4_HUMAN (1-1239): 0: 1238: 100.00		EPHA5_HUMAN (11-976): 0: 1115: 51.34
+	Hs
		348081 M4K4_HUMAN (1-1239): 0: 1238: 100.00		EPHA4_HUMAN (1-974): 0: 1110: 50.35
+	Hs
		348060 M4K4_HUMAN (1-1239): 0: 1238: 100.00		EPHB2_HUMAN (28-973): 0: 1077: 48.29
+	Hs
		710363 MINK1_HUMAN (1-1239): 0: 1130: 59.29		EPHA2_HUMAN (1-976): 0: 1124: 100.00
+	Hs
		1147376 MINK1_HUMAN (1-1239): 0: 1130: 59.29		EPHA7_HUMAN (4-974): 0: 1120: 50.15
+	Hs
		931869 MINK1_HUMAN (1-1239): 0: 1130: 59.29		EPHA5_HUMAN (11-976): 0: 1115: 51.34
+	Hs
		710556 TNIK_HUMAN (1-1239): 0: 1115: 60.45		EPHA2_HUMAN (1-976): 0: 1124: 100.00
+	Hs
		1147461 TNIK_HUMAN (1-1239): 0: 1115: 60.45		EPHA7_HUMAN (4-974): 0: 1120: 50.15
+	Hs
		931911 TNIK_HUMAN (1-1239): 0: 1115: 60.45		EPHA5_HUMAN (11-976): 0: 1115: 51.34
+	Hs
		710914 TNIK_HUMAN (1-1239): 0: 1115: 60.45		EPHB2_HUMAN (28-973): 0: 1077: 48.29
+	Hs
		348054 M4K4_HUMAN (1-1239): 0: 1238: 100.00		EPHA1_HUMAN (17-967): 0: 947: 49.28
+	Hs
		348036 M4K4_HUMAN (1-1239): 0: 1238: 100.00		IGF1R_HUMAN (393-877): 1.45e-133: 437: 29.90
+	Hs
		691998 MARK3_HUMAN (16-680): 1.75e-129: 417: 15.10		EPHA2_HUMAN (1-976): 0: 1124: 100.00
+	Hs
		691999 MARK3_HUMAN (16-680): 1.75e-129: 417: 15.10		EPHB2_HUMAN (28-973): 0: 1077: 48.29
+	Hs
		348035 M4K4_HUMAN (1-1239): 0: 1238: 100.00		LYN_HUMAN (607-879): 2.07e-64: 228: 42.91
+	Hs
		640104 MARK3_HUMAN (16-680): 1.75e-129: 417: 15.10		EPHA1_HUMAN (17-967): 0: 947: 49.28
+	Hs
		463648 MINK1_HUMAN (1-1239): 0: 1130: 59.29		LYN_HUMAN (607-879): 2.07e-64: 228: 42.91
+	Hs
		463831 TNIK_HUMAN (1-1239): 0: 1115: 60.45		LYN_HUMAN (607-879): 2.07e-64: 228: 42.91
+	Hs
		463345 MARK3_HUMAN (16-680): 1.75e-129: 417: 15.10		LYN_HUMAN (607-879): 2.07e-64: 228: 42.91