HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: EPHA1 (P21709)
Ephrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH)
Gene: EPHA1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~fn3, PK_Tyr_Ser-Thr~Pkinase, Pkinase~SAM_1
Common GO terms	GO:0005524 - ATP binding GO:0030335 - positive regulation of cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1239 Hs			1 976
+	Hs
		348128 M4K4_HUMAN (1-1239): 0: 1238: 100.00		EPHA7_HUMAN (2-975): 0: 1125: 43.22
+	Hs
		348081 M4K4_HUMAN (1-1239): 0: 1238: 100.00		EPHA4_HUMAN (5-975): 0: 1110: 43.50
+	Hs
		348060 M4K4_HUMAN (1-1239): 0: 1238: 100.00		EPHB2_HUMAN (27-975): 0: 1109: 40.81
+	Hs
		348080 M4K4_HUMAN (1-1239): 0: 1238: 100.00		EPHA5_HUMAN (3-975): 0: 1109: 41.71
+	Hs
		348059 M4K4_HUMAN (1-1239): 0: 1238: 100.00		EPHA2_HUMAN (24-976): 0: 1053: 49.90
+	Hs
		1147376 MINK1_HUMAN (1-1239): 0: 1130: 59.29		EPHA7_HUMAN (2-975): 0: 1125: 43.22
+	Hs
		1147461 TNIK_HUMAN (1-1239): 0: 1115: 60.45		EPHA7_HUMAN (2-975): 0: 1125: 43.22
+	Hs
		931869 MINK1_HUMAN (1-1239): 0: 1130: 59.29		EPHA5_HUMAN (3-975): 0: 1109: 41.71
+	Hs
		710914 TNIK_HUMAN (1-1239): 0: 1115: 60.45		EPHB2_HUMAN (27-975): 0: 1109: 40.81
+	Hs
		931911 TNIK_HUMAN (1-1239): 0: 1115: 60.45		EPHA5_HUMAN (3-975): 0: 1109: 41.71
+	Hs
		710363 MINK1_HUMAN (1-1239): 0: 1130: 59.29		EPHA2_HUMAN (24-976): 0: 1053: 49.90
+	Hs
		710556 TNIK_HUMAN (1-1239): 0: 1115: 60.45		EPHA2_HUMAN (24-976): 0: 1053: 49.90
+	Hs
		691999 MARK3_HUMAN (16-680): 1.75e-129: 417: 15.10		EPHB2_HUMAN (27-975): 0: 1109: 40.81
+	Hs
		640104 MARK3_HUMAN (16-680): 1.75e-129: 417: 15.10		EPHA1_HUMAN (1-976): 0: 1103: 100.00
+	Hs
		728251 AKT1_HUMAN (2-354): 1.3e-122: 389: 20.82		EPHA7_HUMAN (2-975): 0: 1125: 43.22
+	Hs
		348114 M4K4_HUMAN (1-1239): 0: 1238: 100.00		FAK1_HUMAN (630-884): 1.18e-63: 236: 45.88
+	Hs
		691998 MARK3_HUMAN (16-680): 1.75e-129: 417: 15.10		EPHA2_HUMAN (24-976): 0: 1053: 49.90
+	Hs
		710085 AKT1_HUMAN (2-354): 1.3e-122: 389: 20.82		EPHA2_HUMAN (24-976): 0: 1053: 49.90
+	Rn
		580454 AAPK1_RAT (8-555): 1.42e-122: 392: 16.85		INSR_RAT (391-882): 7.94e-131: 430: 26.99
+	Mm
		581952 AKT1_MOUSE (2-354): 7.67e-123: 390: 20.82		INSR_MOUSE (387-882): 4.19e-130: 427: 26.40