HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: FZR1 (Q9UM11)
Fizzy-related protein homolog (Fzr) (CDC20-like protein 1) (Cdh1/Hct1 homolog) (hCDH1)
Gene: FZR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.585

Property	Details
Experiments	28205554, 21150319
Identification Methods	fluorescent resonance energy transfer, tandem affinity purification
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0008284 - positive regulation of cell population proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 454 Hs			1 496
+	Hs
		347517 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		FBXW7_HUMAN (87-424): 1.7e-71: 242: 18.68
+	Mm
		348444 MYC_MOUSE (1-454): 4.33e-119: 357: 89.01		FBXW7_MOUSE (87-424): 5.08e-72: 243: 18.68
+	Hs
		348035 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		NLE1_HUMAN (52-385): 3.28e-60: 207: 16.32
+	Hs
		346159 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		LIS1_HUMAN (309-495): 7.12e-53: 185: 19.68
+	Hs
		347550 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		SNR40_HUMAN (32-339): 1.33e-49: 175: 15.89
+	Hs
		346404 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		WDR5_HUMAN (389-496): 1.49e-26: 111: 18.35
+	Hs
		379688 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		FBXW7_HUMAN (87-424): 1.7e-71: 242: 18.68
+	Hs
		346645 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		CDC20_HUMAN (395-494): 7.34e-10: 63: 16.67
+	Dm
		1375911 MYC_DROME (210-454): 3.25e-30: 126: 26.74		FBXW7_DROME (20-496): 6.04e-89: 298: 17.46
+	Mm
		1112323 SRBP2_MOUSE (124-446): 2.23e-37: 147: 13.60		FBXW7_MOUSE (87-424): 5.08e-72: 243: 18.68
+	Mm
		1257396 SRBP1_MOUSE (172-453): 4.45e-35: 140: 16.61		FBXW7_MOUSE (87-424): 5.08e-72: 243: 18.68
+	Hs
		738987 SRBP1_HUMAN (95-453): 2.54e-33: 135: 16.19		FBXW7_HUMAN (87-424): 1.7e-71: 242: 18.68
+	Hs
		379701 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		SNR40_HUMAN (32-339): 1.33e-49: 175: 15.89
+	Hs
		379200 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		WDR5_HUMAN (389-496): 1.49e-26: 111: 18.35
+	Hs
		1218698 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		SNR40_HUMAN (32-339): 1.33e-49: 175: 15.89
+	Hs
		607803 USF1_HUMAN (175-453): 1.02e-39: 146: 18.40		WDR5_HUMAN (389-496): 1.49e-26: 111: 18.35
+	Hs
		903353 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		WDR5_HUMAN (389-496): 1.49e-26: 111: 18.35
+	Mm
		659344 MAX_MOUSE (354-454): 3.52e-25: 102: 32.67		WDR5_MOUSE (389-496): 1.49e-26: 111: 18.35
+	Hs
		898091 MAX_HUMAN (354-454): 1.39e-24: 101: 32.67		WDR5_HUMAN (389-496): 1.49e-26: 111: 18.35
+	Hs
		840206 MXI1_HUMAN (321-450): 2.55e-29: 116: 27.69		CDC20_HUMAN (395-494): 7.34e-10: 63: 16.67