Protein: M4K4
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)

Gene: M4K4, Map4k4
Organism: Mus musculus
Interactions: 20
UniProt ID: P97820

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005925 - focal adhesion
GO:0006468 - protein phosphorylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1013558

TNIK
Traf2 and NCK-interacting protein kinase

1

17

High-throughput

0.691

High

1021937

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

13

High-throughput

0.691

High

728517

AKT1
RAC-alpha serine/threonine-protein kinase

1

18

Small-scale

0.618

High

1021938

AKT2
RAC-beta serine/threonine-protein kinase

1

20

Small-scale

0.618

High

1021949

AKT3
RAC-gamma serine/threonine-protein kinase

1

18

Small-scale

0.618

High

1021944

PTK7
Inactive tyrosine-protein kinase 7

1

20

High-throughput

0.553

High

1021946

FNDC5
Fibronectin type III domain-containing protein 5

1

1

High-throughput

0.553

High

1021939

FXR1
RNA-binding protein FXR1

1

9

High-throughput

0.536

High

1021943

MYOME
Myomegalin

1

20

High-throughput

0.536

High

1021940

CE290
Centrosomal protein of 290 kDa

1

20

High-throughput

0.489

High

1021942

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

7

High-throughput

0.489

High

1021948

DLGP1
Disks large-associated protein 1

1

2

High-throughput

0.489

High

1021936

STING
Stimulator of interferon genes protein

1

4

High-throughput

0.479

High

1021945

Q8BPK8
Fragile X messenger ribonucleoprotein 1

1

9

High-throughput

0.479

High

927729

ATX1
Ataxin-1

1

0

High-throughput

0.458

High

1021941

TEDC2
Tubulin epsilon and delta complex protein 2

1

0

High-throughput

0.458

High

777866

FMR1
Fragile X messenger ribonucleoprotein 1

1

9

High-throughput

0.445

High

108641

G3X9H5
Huntingtin

1

3

High-throughput

0.437

High

398342

CFAD
Complement factor D

1

3

High-throughput

0.437

High

1021947

NCK1
SH2/SH3 adapter protein Nck1

1

20

High-throughput

0.417

High


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Last updated: 11Aug2025