HitPredict

Interactor 1: RPA49 (Q9GZS1)
DNA-directed RNA polymerase I subunit RPA49 (RNA polymerase I subunit A49) (DNA-directed RNA polymerase I subunit E) (RNA polymerase I-associated factor 1) (RNA polymerase I-associated factor 53)
Gene: POLR1E

Interactor 2: RPA2 (Q9H9Y6)
DNA-directed RNA polymerase I subunit RPA2 (RNA polymerase I subunit 2) (EC 2.7.7.6) (DNA-directed RNA polymerase I 135 kDa polypeptide) (RPA135)
Gene: POLR1B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.886

Property	Details
Experiments	35271311, 24207024, 24981860, 34079125
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RNA_pol_I_A49~RNA_pol_Rpb2_1, RNA_pol_I_A49~RNA_pol_Rpb2_6, RNA_pol_I_A49~RNA_pol_Rpb2_7
Common GO terms	GO:0001650 - fibrillar center GO:0003677 - DNA binding GO:0005654 - nucleoplasm GO:0005736 - RNA polymerase I complex
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 419 Hs			1 1135
+	Mm
		936933 RPA49_MOUSE (4-418): 0: 514: 69.55		RPA2_MOUSE (1-1135): 0: 1501: 90.31
+	Hs
		676994 RPA49_HUMAN (1-419): 0: 544: 100.00		RPB2_HUMAN (18-1135): 0: 1296: 27.87
+	Hs
		1326435 RPA49_HUMAN (1-419): 0: 544: 100.00		RPC2_HUMAN (12-1134): 0: 1210: 28.58
+	Sc
		604601 RPA49_YEAST (16-417): 4.24e-109: 329: 19.66		RPA2_YEAST (29-1134): 0: 1219: 42.49
+	Hs
		1326412 RPA49_HUMAN (1-419): 0: 544: 100.00		Q9H6S8_HUMAN (642-1094): 0: 688: 95.36