HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	39115278, 34273398
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1239 Hs			1 1620
+	Hs
		1461048 TNIK_HUMAN (1-1239): 0: 1115: 60.45		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Hs
		692157 MARK3_HUMAN (16-680): 1.75e-129: 417: 15.10		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Hs
		348060 M4K4_HUMAN (1-1239): 0: 1238: 100.00		EPHB2_HUMAN (938-1436): 1.28e-127: 427: 23.26
+	Hs
		348036 M4K4_HUMAN (1-1239): 0: 1238: 100.00		IGF1R_HUMAN (1037-1385): 8.56e-111: 386: 39.77
+	Hs
		348123 M4K4_HUMAN (1-1239): 0: 1238: 100.00		FAK2_HUMAN (1054-1518): 3.57e-109: 374: 27.45
+	Hs
		710914 TNIK_HUMAN (1-1239): 0: 1115: 60.45		EPHB2_HUMAN (938-1436): 1.28e-127: 427: 23.26
+	Hs
		348029 M4K4_HUMAN (1-1239): 0: 1238: 100.00		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		348130 M4K4_HUMAN (1-1239): 0: 1238: 100.00		NTRK3_HUMAN (1093-1375): 2.7e-59: 223: 39.03
+	Hs
		348044 M4K4_HUMAN (1-1239): 0: 1238: 100.00		FGFR1_HUMAN (1110-1403): 6.78e-55: 209: 38.07
+	Mm
		581980 TNIK_MOUSE (1-1239): 0: 1135: 62.25		NTRK2_MOUSE (1093-1379): 6.23e-64: 236: 41.22
+	Hs
		1159515 MINK1_HUMAN (1-1239): 0: 1130: 59.29		NTRK2_HUMAN (1093-1375): 7.39e-64: 236: 41.44
+	Hs
		1156996 MINK1_HUMAN (1-1239): 0: 1130: 59.29		NTRK3_HUMAN (1093-1375): 2.7e-59: 223: 39.03
+	Hs
		541588 MINK1_HUMAN (1-1239): 0: 1130: 59.29		FGFR1_HUMAN (1110-1403): 6.78e-55: 209: 38.07
+	Hs
		1157105 TNIK_HUMAN (1-1239): 0: 1115: 60.45		NTRK3_HUMAN (1093-1375): 2.7e-59: 223: 39.03
+	Hs
		541750 TNIK_HUMAN (1-1239): 0: 1115: 60.45		FGFR1_HUMAN (1110-1403): 6.78e-55: 209: 38.07
+	Hs
		691999 MARK3_HUMAN (16-680): 1.75e-129: 417: 15.10		EPHB2_HUMAN (938-1436): 1.28e-127: 427: 23.26
+	Hs
		692072 MARK3_HUMAN (16-680): 1.75e-129: 417: 15.10		NTRK2_HUMAN (1093-1375): 7.39e-64: 236: 41.44
+	Hs
		411397 MARK3_HUMAN (16-680): 1.75e-129: 417: 15.10		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		541351 MARK3_HUMAN (16-680): 1.75e-129: 417: 15.10		FGFR1_HUMAN (1110-1403): 6.78e-55: 209: 38.07
+	At
		1192625 CDPK3_ARATH (16-467): 3.18e-126: 401: 19.06		BRL3_ARATH (532-1043): 8.19e-23: 108: 10.57