Protein: FAK2
Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)

Gene: FAK2, PTK2B
Organism: Homo sapiens
Interactions: 100
UniProt ID: Q14289

Gene Ontology (top 5):
GO:0001764 - neuron migration
GO:0001954 - positive regulation of cell-matrix adhesion
GO:0002040 - sprouting angiogenesis
GO:0002250 - adaptive immune response
GO:0002315 - marginal zone B cell differentiation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

878458

PAXI
Paxillin

8

20

Small-scale

0.970

High

440556

FYN
Tyrosine-protein kinase Fyn

6

20

Small-scale

0.950

High

557304

SRC
Proto-oncogene tyrosine-protein kinase Src

6

20

Small-scale

0.944

High

212726

TGFI1
Transforming growth factor beta-1-induced transcript 1 protein

5

20

Small-scale

0.942

High

942609

BCAR1
Breast cancer anti-estrogen resistance protein 1

4

20

Small-scale

0.874

High

363283

EGFR
Epidermal growth factor receptor

4

20

Small-scale

0.867

High

987637

GRB2
Growth factor receptor-bound protein 2

4

20

Small-scale

0.867

High

184293

NPHP1
Nephrocystin-1

2

1

Small-scale

0.806

High

635717

RASA1
Ras GTPase-activating protein 1

2

20

Small-scale

0.806

High

711125

PTN6
Tyrosine-protein phosphatase non-receptor type 6

2

20

Small-scale

0.806

High

286772

SKAP2
Src kinase-associated phosphoprotein 2

2

20

Small-scale

0.793

High

827777

STAT3
Signal transducer and activator of transcription 3

2

20

Small-scale

0.763

High

155943

SOCS3
Suppressor of cytokine signaling 3

2

20

Small-scale

0.757

High

1053662

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

20

Small-scale

0.747

High

348123

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

20

Small-scale

0.740

High

207921

ASAP2
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2

1

20

Small-scale

0.724

High

320241

SRBS2
Sorbin and SH3 domain-containing protein 2

1

20

Small-scale

0.724

High

1006062

DLG4
Disks large homolog 4

1

20

Small-scale

0.724

High

1125290

DLG3
Disks large homolog 3

1

20

Small-scale

0.724

High

155110

SOCS2
Suppressor of cytokine signaling 2

1

20

Small-scale

0.713

High

49967

RHG10
Rho GTPase-activating protein 10

1

20

High-throughput

0.691

High

1034991

KPCE
Protein kinase C epsilon type

1

19

High-throughput

0.691

High

1125286

RHOU
Rho-related GTP-binding protein RhoU

1

20

Small-scale

0.683

High

572827

NCF1
Neutrophil cytosol factor 1

1

20

Small-scale

0.665

High

584539

VAV
Proto-oncogene vav

1

20

Small-scale

0.647

High

1050790

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

20

Small-scale

0.647

High

1125281

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.647

High

651327

CBL
E3 ubiquitin-protein ligase CBL

3

20

Small-scale

0.640

High

840851

MATK
Megakaryocyte-associated tyrosine-protein kinase

1

20

Small-scale

0.625

High

253349

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.618

High

410838

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.618

High

440074

LCK
Tyrosine-protein kinase Lck

1

19

Small-scale

0.618

High

461473

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

463517

LYN
Tyrosine-protein kinase Lyn

1

20

Small-scale

0.618

High

468368

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

599203

IL7RA
Interleukin-7 receptor subunit alpha

1

2

Small-scale

0.618

High

641597

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

Small-scale

0.618

High

658706

JAK1
Tyrosine-protein kinase JAK1

1

20

Small-scale

0.618

High

699746

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

20

Small-scale

0.618

High

711351

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.618

High

730582

1433S
14-3-3 protein sigma

1

20

High-throughput

0.618

High

849169

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.618

High

911921

JAK3
Tyrosine-protein kinase JAK3

1

20

Small-scale

0.618

High

971523

1433E
14-3-3 protein epsilon

1

7

High-throughput

0.618

High

1050679

DYN1
Dynamin-1

1

17

Small-scale

0.618

High

1051925

KPCD
Protein kinase C delta type

1

20

Small-scale

0.618

High

1125283

CASL
Enhancer of filamentation 1

1

20

Small-scale

0.618

High

1125285

TRI67
Tripartite motif-containing protein 67

1

19

High-throughput

0.618

High

1125291

SH3K1
SH3 domain-containing kinase-binding protein 1

1

20

Small-scale

0.618

High

1125307

TLN1
Talin-1

1

20

Small-scale

0.618

High

1125308

M3K4
Mitogen-activated protein kinase kinase kinase 4

1

4

Small-scale

0.618

High

1125295

TRAF4
TNF receptor-associated factor 4

2

14

Small-scale

0.611

High

247329

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

20

High-throughput

0.590

High

1125302

CASS4
Cas scaffolding protein family member 4

1

20

High-throughput

0.590

High

1125304

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

9

High-throughput

0.590

High

1088768

NMDE1
Glutamate receptor ionotropic, NMDA 2A

2

20

Small-scale

0.584

High

1125289

PDC6I
Programmed cell death 6-interacting protein

2

19

Small-scale

0.584

High

253952

LPXN
Leupaxin

2

20

Small-scale

0.576

High

442316

GELS
Gelsolin

1

6

Small-scale

0.573

High

1125288

RBCC1
RB1-inducible coiled-coil protein 1

1

20

Small-scale

0.573

High

1125296

PITM3
Membrane-associated phosphatidylinositol transfer protein 3

1

4

Small-scale

0.573

High

431810

ITB1
Integrin beta-1

2

20

Small-scale

0.571

High

1032958

EWS
RNA-binding protein EWS

1

3

Small-scale

0.561

High

140507

PITM1
Membrane-associated phosphatidylinositol transfer protein 1

1

4

Small-scale

0.552

High

1125297

PITM2
Membrane-associated phosphatidylinositol transfer protein 2

1

4

Small-scale

0.552

High

1125303

MBD2
Methyl-CpG-binding domain protein 2

1

0

Small-scale

0.549

High

1125298

ZFHX2
Zinc finger homeobox protein 2

1

4

High-throughput

0.536

High

422102

A4
Amyloid-beta precursor protein

1

17

High-throughput

0.515

High

424032

ITB3
Integrin beta-3

1

20

Small-scale

0.501

High

529793

TAU
Microtubule-associated protein tau

1

20

Small-scale

0.501

High

666294

THIL
Acetyl-CoA acetyltransferase, mitochondrial

1

2

High-throughput

0.489

High

273346

NPHP4
Nephrocystin-4

1

2

Small-scale

0.479

High

325835

UBR5
E3 ubiquitin-protein ligase UBR5

1

20

Small-scale

0.479

High

424079

ITB2
Integrin beta-2

1

20

Small-scale

0.479

High

538592

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

2

Small-scale

0.479

High

560968

GP1BB
Platelet glycoprotein Ib beta chain

1

17

Small-scale

0.479

High

595047

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

14

Small-scale

0.479

High

861607

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

20

Small-scale

0.479

High

931660

RD23B
UV excision repair protein RAD23 homolog B

1

1

High-throughput

0.479

High

951672

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

20

Small-scale

0.479

High

1097935

CBLB
E3 ubiquitin-protein ligase CBL-B

1

20

Small-scale

0.479

High

1099650

GRM1
Metabotropic glutamate receptor 1

1

8

Small-scale

0.479

High

1125282

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

6

Small-scale

0.479

High

1125284

PEAK3
Protein PEAK3

1

6

Small-scale

0.479

High

1125293

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

20

Small-scale

0.479

High

1125294

MYD88
Myeloid differentiation primary response protein MyD88

1

7

Small-scale

0.479

High

1125301

GPVI
Platelet glycoprotein VI

1

14

Small-scale

0.479

High

1125306

GIT1
ARF GTPase-activating protein GIT1

1

20

Small-scale

0.479

High

685193

PAX6
Paired box protein Pax-6

1

6

High-throughput

0.457

High

845641

MUC18
Cell surface glycoprotein MUC18

1

19

High-throughput

0.457

High

1026029

CLH1
Clathrin heavy chain 1

1

5

High-throughput

0.457

High

1125292

CF418
Cilia- and flagella-associated protein 418

1

1

Small-scale

0.457

High

448028

ITAV
Integrin alpha-V

1

12

Small-scale

0.445

High

1023776

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

1

High-throughput

0.445

High

1125287

DOCK8
Dedicator of cytokinesis protein 8

1

9

Small-scale

0.445

High

105929

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

1125300

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

1

1

Small-scale

0.437

High

1125299

CPVL
Probable serine carboxypeptidase CPVL

1

0

High-throughput

0.279

Low

1125305

EXC6B
Exocyst complex component 6B

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025