HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: RIN2 (Q8WYP3)
Ras and Rab interactor 2 (Ras association domain family 4) (Ras inhibitor JC265) (Ras interaction/interference protein 2)
Gene: RIN2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	34591642
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	RA~Ras, Ras~VPS9
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 895
+	Hs
		349534 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		RIN2_HUMAN (1-895): 0: 1026: 100.00
+	Hs
		1137131 Q5U0I6_HUMAN (4-187): 1.35e-76: 229: 33.33		RIN3_HUMAN (66-874): 0: 615: 31.01
+	Hs
		918912 RAB1A_HUMAN (4-187): 1.35e-76: 229: 33.33		RIN3_HUMAN (66-874): 0: 615: 31.01
+	Hs
		1061919 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		GAPD1_HUMAN (215-755): 1.75e-79: 284: 13.20
+	Dm
		443000 RAS1_DROME (1-170): 2.87e-90: 263: 83.53		SPRI_DROME (69-471): 6.47e-69: 252: 18.92
+	Hs
		349717 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		RABX5_HUMAN (393-781): 9.51e-82: 274: 14.50
+	Hs
		350154 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		RIN1_HUMAN (70-580): 3.49e-59: 218: 22.12
+	Hs
		348653 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		RIN1_HUMAN (70-580): 3.49e-59: 218: 22.12
+	Hs
		349304 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		RIN1_HUMAN (70-580): 3.49e-59: 218: 22.12
+	Mm
		1142563 RASH_MOUSE (1-188): 8.6e-78: 232: 85.64		RIN1_MOUSE (71-580): 5.47e-57: 211: 20.08
+	Hs
		349066 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		FYN_HUMAN (37-218): 4.85e-50: 187: 19.79
+	Hs
		349806 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		YES_HUMAN (37-218): 3.53e-41: 161: 19.25
+	Hs
		433358 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		YES_HUMAN (37-218): 3.53e-41: 161: 19.25
+	Hs
		348473 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		YES_HUMAN (37-218): 3.53e-41: 161: 19.25
+	Hs
		349836 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		SRC_HUMAN (37-218): 4.05e-36: 146: 19.79
+	Hs
		349069 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		YES_HUMAN (37-218): 3.53e-41: 161: 19.25
+	Hs
		350250 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		TENS3_HUMAN (77-223): 2.71e-34: 144: 21.95
+	Hs
		348488 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		SRC_HUMAN (37-218): 4.05e-36: 146: 19.79
+	Hs
		349095 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		SRC_HUMAN (37-218): 4.05e-36: 146: 19.79
+	Rn
		589762 RASH_RAT (1-188): 8.6e-78: 232: 85.64		SRC_RAT (37-218): 5.74e-36: 145: 19.79