Protein: CLC2D
C-type lectin domain family 2 member D (Lectin-like NK cell receptor) (Lectin-like transcript 1) (LLT-1) (Osteoclast inhibitory lectin)

Gene: CLC2D, CLEC2D
Organism: Homo sapiens
Interactions: 206
UniProt ID: Q9UHP7

Gene Ontology (top 5):
GO:0004888 - transmembrane signaling receptor activity
GO:0005783 - endoplasmic reticulum
GO:0005886 - plasma membrane
GO:0007166 - cell surface receptor signaling pathway
GO:0009897 - external side of plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1207974

COL12
Collectin-12

2

17

High-throughput

0.811

High

1366845

PTPRU
Receptor-type tyrosine-protein phosphatase U

2

8

High-throughput

0.811

High

1419502

CNTP3
Contactin-associated protein-like 3

2

14

High-throughput

0.811

High

1460034

FND3A
Fibronectin type-III domain-containing protein 3A

2

11

High-throughput

0.811

High

688642

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

2

17

High-throughput

0.783

High

1248268

CLC2A
C-type lectin domain family 2 member A

2

16

High-throughput

0.783

High

380665

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

1

20

High-throughput

0.691

High

719754

HLAF
HLA class I histocompatibility antigen, alpha chain F

1

20

High-throughput

0.691

High

953163

ACTB
Actin, cytoplasmic 1

1

6

High-throughput

0.691

High

1009169

DRB3
HLA class II histocompatibility antigen, DR beta 3 chain

1

20

High-throughput

0.691

High

1237972

LRC8E
Volume-regulated anion channel subunit LRRC8E

1

1

High-throughput

0.691

High

1247533

POTEE
POTE ankyrin domain family member E

1

5

High-throughput

0.691

High

1384395

SO4A1
Solute carrier organic anion transporter family member 4A1

1

3

High-throughput

0.691

High

1275427

ERMP1
Endoplasmic reticulum metallopeptidase 1

4

5

High-throughput

0.689

High

1363574

FAM3C
Protein FAM3C

3

9

High-throughput

0.665

High

1047251

ATP7A
Copper-transporting ATPase 1

3

8

High-throughput

0.662

High

1323779

S39AB
Zinc transporter ZIP11

3

7

High-throughput

0.662

High

1395984

DNJC1
DnaJ homolog subfamily C member 1

3

7

High-throughput

0.662

High

1416868

TACAN
Transmembrane protein 120A

3

1

High-throughput

0.662

High

1090118

KLRB1
Killer cell lectin-like receptor subfamily B member 1

1

18

Small-scale

0.647

High

186447

TM9S1
Transmembrane 9 superfamily member 1

2

3

High-throughput

0.628

High

321790

AGRL1
Adhesion G protein-coupled receptor L1

2

10

High-throughput

0.628

High

341375

ECEL1
Endothelin-converting enzyme-like 1

2

4

High-throughput

0.628

High

552432

ADT3
ADP/ATP translocase 3

2

5

High-throughput

0.628

High

561001

GP1BB
Platelet glycoprotein Ib beta chain

2

18

High-throughput

0.628

High

638258

S1PR1
Sphingosine 1-phosphate receptor 1

2

9

High-throughput

0.628

High

699237

CALX
Calnexin

2

20

High-throughput

0.628

High

775780

ATP7B
Copper-transporting ATPase 2

2

10

High-throughput

0.628

High

870835

GLRB
Glycine receptor subunit beta

2

3

High-throughput

0.628

High

931309

AT12A
Potassium-transporting ATPase alpha chain 2

2

8

High-throughput

0.628

High

1010544

EREP3
Protein ENTREP3

2

4

High-throughput

0.628

High

1023450

AT8B2
Phospholipid-transporting ATPase ID

2

7

High-throughput

0.628

High

1111526

MTR1L
Melatonin-related receptor

2

6

High-throughput

0.628

High

1248523

SUSD1
Sushi domain-containing protein 1

2

20

High-throughput

0.628

High

1280084

FRMD5
FERM domain-containing protein 5

2

5

High-throughput

0.628

High

1293309

LSR
Lipolysis-stimulated lipoprotein receptor

2

2

High-throughput

0.628

High

1356607

CHPT1
Cholinephosphotransferase 1

2

1

High-throughput

0.628

High

1358450

LMBR1
Limb region 1 protein homolog

2

1

High-throughput

0.628

High

1361328

CTR3
Cationic amino acid transporter 3

2

9

High-throughput

0.628

High

1362090

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

2

10

High-throughput

0.628

High

1431091

TMX4
Thioredoxin-related transmembrane protein 4

2

10

High-throughput

0.628

High

1445838

ABCB6
ATP-binding cassette sub-family B member 6

2

6

High-throughput

0.628

High

1450100

MITOS
Mitochondrial potassium channel ATP-binding subunit

2

5

High-throughput

0.628

High

1452276

SL2A8
Solute carrier family 2, facilitated glucose transporter member 8

2

1

High-throughput

0.628

High

1460040

BACE2
Beta-secretase 2

2

4

High-throughput

0.628

High

165200

TSN4
Tetraspanin-4

2

14

High-throughput

0.606

High

329679

LERL1
Leptin receptor overlapping transcript-like 1

2

1

High-throughput

0.606

High

688424

PPLA
Phospholamban

2

1

High-throughput

0.606

High

692277

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

2

6

High-throughput

0.606

High

760782

CD68
Macrosialin

2

5

High-throughput

0.606

High

945201

CLD2
Claudin-2

2

7

High-throughput

0.606

High

949304

MYPR
Myelin proteolipid protein

2

1

High-throughput

0.606

High

1031683

ILRL1
Interleukin-1 receptor-like 1

2

10

High-throughput

0.606

High

1059109

CXCL9
C-X-C motif chemokine 9

2

5

High-throughput

0.606

High

1155049

ADIPO
Adiponectin

2

12

High-throughput

0.606

High

1159490

NKG7
Protein NKG7

2

2

High-throughput

0.606

High

1208422

ENTP8
Ectonucleoside triphosphate diphosphohydrolase 8

2

1

High-throughput

0.606

High

1245938

BRID5
BRICHOS domain-containing protein 5

2

2

High-throughput

0.606

High

1329255

CLD19
Claudin-19

2

7

High-throughput

0.606

High

1348800

FNDC9
Fibronectin type III domain-containing protein 9

2

2

High-throughput

0.606

High

1385812

T4S18
Transmembrane 4 L6 family member 18

2

1

High-throughput

0.606

High

1449095

RPRM
Protein reprimo

2

3

High-throughput

0.606

High

1460033

B3GT5
Beta-1,3-galactosyltransferase 5

2

1

High-throughput

0.606

High

1460036

PLLP
Plasmolipin

2

8

High-throughput

0.606

High

1214138

DIK1A
Divergent protein kinase domain 1A

3

5

High-throughput

0.604

High

50128

S22AN
Solute carrier family 22 member 23

2

0

High-throughput

0.602

High

256186

S19A2
Thiamine transporter 1

2

0

High-throughput

0.602

High

316584

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

2

2

High-throughput

0.601

High

1287466

SYVN1
E3 ubiquitin-protein ligase synoviolin

2

6

High-throughput

0.601

High

1438415

S38AA
Solute carrier family 38 member 10

2

5

High-throughput

0.601

High

1393141

TMM80
Transmembrane protein 80

2

0

High-throughput

0.580

High

1410927

SYT15
Synaptotagmin-15

2

0

High-throughput

0.580

High

1353677

LRC15
Leucine-rich repeat-containing protein 15

1

13

High-throughput

0.575

High

49712

T120B
Transmembrane protein 120B

2

1

High-throughput

0.574

High

227034

MCAT
Mitochondrial carnitine/acylcarnitine carrier protein

2

7

High-throughput

0.574

High

1133242

STAR3
StAR-related lipid transfer protein 3

2

3

High-throughput

0.574

High

1200290

FAKD1
FAST kinase domain-containing protein 1, mitochondrial

2

7

High-throughput

0.574

High

1216537

BIG3
Brefeldin A-inhibited guanine nucleotide-exchange protein 3

2

5

High-throughput

0.574

High

1335224

NETO2
Neuropilin and tolloid-like protein 2

2

7

High-throughput

0.574

High

1336784

SIA7C
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

2

11

High-throughput

0.574

High

1381624

NXPE3
NXPE family member 3

2

1

High-throughput

0.574

High

1386109

EVI5L
EVI5-like protein

2

2

High-throughput

0.574

High

1393585

INT4
Integrator complex subunit 4

2

2

High-throughput

0.574

High

1430933

XYLT2
Xylosyltransferase 2

2

2

High-throughput

0.574

High

1439091

K1586
E3 SUMO-protein ligase KIAA1586

2

2

High-throughput

0.574

High

1458733

FA8A1
Protein FAM8A1

2

2

High-throughput

0.574

High

49824

CLRN2
Clarin-2

2

2

High-throughput

0.553

High

1361973

TM190
Transmembrane protein 190

2

1

High-throughput

0.553

High

1394466

SC22A
Vesicle-trafficking protein SEC22a

2

7

High-throughput

0.553

High

1454017

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

2

4

High-throughput

0.549

High

48839

ESYT2
Extended synaptotagmin-2

1

3

High-throughput

0.536

High

61150

T131L
Transmembrane protein 131-like

1

2

High-throughput

0.536

High

178584

PLCB
1-acyl-sn-glycerol-3-phosphate acyltransferase beta

1

14

High-throughput

0.536

High

276983

MPU1
Mannose-P-dolichol utilization defect 1 protein

1

1

High-throughput

0.536

High

343864

SEM4F
Semaphorin-4F

1

12

High-throughput

0.536

High

552092

ADT1
ADP/ATP translocase 1

1

5

High-throughput

0.536

High

565731

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

9

High-throughput

0.536

High

617356

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

6

High-throughput

0.536

High

627426

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

10

High-throughput

0.536

High

723706

NTR1
Neurotensin receptor type 1

1

4

High-throughput

0.536

High

788552

SCNNA
Epithelial sodium channel subunit alpha

1

3

High-throughput

0.536

High

878108

AGRE5
Adhesion G protein-coupled receptor E5

1

10

High-throughput

0.536

High

905698

IRAK1
Interleukin-1 receptor-associated kinase 1

1

1

High-throughput

0.536

High

1023404

AT2C1
Calcium-transporting ATPase type 2C member 1

1

7

High-throughput

0.536

High

1116929

MOGS
Mannosyl-oligosaccharide glucosidase

1

1

High-throughput

0.536

High

1125878

FZD2
Frizzled-2

1

4

High-throughput

0.536

High

1126052

GAS6
Growth arrest-specific protein 6

1

15

High-throughput

0.536

High

1143812

PON2
Serum paraoxonase/arylesterase 2

1

3

High-throughput

0.536

High

1154082

MSMO1
Methylsterol monooxygenase 1

1

1

High-throughput

0.536

High

1159184

SGCB
Beta-sarcoglycan

1

2

High-throughput

0.536

High

1204601

PIGG
GPI ethanolamine phosphate transferase 2, catalytic subunit

1

5

High-throughput

0.536

High

1213217

AGRF1
Adhesion G-protein coupled receptor F1

1

9

High-throughput

0.536

High

1218871

GP107
Protein GPR107

1

2

High-throughput

0.536

High

1228859

LMBD2
G-protein coupled receptor-associated protein LMBRD2

1

1

High-throughput

0.536

High

1242470

CNNM4
Metal transporter CNNM4

1

5

High-throughput

0.536

High

1248688

LCLT1
Lysocardiolipin acyltransferase 1

1

7

High-throughput

0.536

High

1259555

TBA1A
Tubulin alpha-1A chain

1

8

High-throughput

0.536

High

1289024

NLRX1
NLR family member X1

1

1

High-throughput

0.536

High

1336110

KREM2
Kremen protein 2

1

10

High-throughput

0.536

High

1336138

GLT11
Polypeptide N-acetylgalactosaminyltransferase 11

1

13

High-throughput

0.536

High

1337081

CNNM3
Metal transporter CNNM3

1

5

High-throughput

0.536

High

1350098

SPP2B
Signal peptide peptidase-like 2B

1

2

High-throughput

0.536

High

1357255

S38A5
Sodium-coupled neutral amino acid transporter 5

1

5

High-throughput

0.536

High

1364121

TM9S4
Transmembrane 9 superfamily member 4

1

3

High-throughput

0.536

High

1372415

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

9

High-throughput

0.536

High

1380556

PIGT
GPI-anchor transamidase component PIGT

1

1

High-throughput

0.536

High

1384634

S67A1
Solute carrier family 67 member A1

1

2

High-throughput

0.536

High

1390793

S47A1
Multidrug and toxin extrusion protein 1

1

2

High-throughput

0.536

High

1391672

VMP1
Vacuole membrane protein 1

1

1

High-throughput

0.536

High

1410975

CSTN3
Calsyntenin-3

1

17

High-throughput

0.536

High

1412076

S39A3
Zinc transporter ZIP3

1

7

High-throughput

0.536

High

1415282

PTSS2
Phosphatidylserine synthase 2

1

1

High-throughput

0.536

High

1419577

ABCA2
ATP-binding cassette sub-family A member 2

1

3

High-throughput

0.536

High

1428318

DERL2
Derlin-2

1

1

High-throughput

0.536

High

1430571

LMA2L
VIP36-like protein

1

6

High-throughput

0.536

High

1430890

METL9
Protein-L-histidine N-pros-methyltransferase

1

1

High-throughput

0.536

High

1432218

SPNS1
Protein spinster homolog 1

1

1

High-throughput

0.536

High

1436438

CNNM2
Metal transporter CNNM2

1

5

High-throughput

0.536

High

1437616

AGRL3
Adhesion G protein-coupled receptor L3

1

9

High-throughput

0.536

High

1439667

TM9S3
Transmembrane 9 superfamily member 3

1

3

High-throughput

0.536

High

1446826

GPC5C
G-protein coupled receptor family C group 5 member C

1

1

High-throughput

0.536

High

1449026

PLCD
1-acyl-sn-glycerol-3-phosphate acyltransferase delta

1

7

High-throughput

0.536

High

1450323

CC50A
Cell cycle control protein 50A

1

5

High-throughput

0.536

High

1450559

FANCI
Fanconi anemia group I protein

1

2

High-throughput

0.536

High

1452204

S39A1
Zinc transporter ZIP1

1

7

High-throughput

0.536

High

1453780

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

3

High-throughput

0.536

High

1460029

GGT7
Glutathione hydrolase 7

1

1

High-throughput

0.536

High

1460030

S39AA
Zinc transporter ZIP10

1

7

High-throughput

0.536

High

1460031

XCT
Cystine/glutamate transporter

1

9

High-throughput

0.536

High

1460032

SIA10
Type 2 lactosamine alpha-2,3-sialyltransferase

1

11

High-throughput

0.536

High

1460035

MAN1
Inner nuclear membrane protein Man1

1

1

High-throughput

0.536

High

1460041

ORNT1
Mitochondrial ornithine transporter 1

1

10

High-throughput

0.536

High

1460042

BIG2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2

1

5

High-throughput

0.536

High

506682

GPHRB
Golgi pH regulator B

2

1

High-throughput

0.533

High

462695

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

5

High-throughput

0.515

High

193465

GPR42
G-protein coupled receptor 42

1

5

High-throughput

0.515

High

301750

WFS1
Wolframin

1

1

High-throughput

0.515

High

341488

CDS2
Phosphatidate cytidylyltransferase 2

1

0

High-throughput

0.513

High

800243

VKGC
Vitamin K-dependent gamma-carboxylase

1

0

High-throughput

0.513

High

844894

EAA1
Excitatory amino acid transporter 1

1

0

High-throughput

0.513

High

1243337

INT5
Integrator complex subunit 5

1

0

High-throughput

0.513

High

1270864

SV2A
Synaptic vesicle glycoprotein 2A

1

0

High-throughput

0.513

High

1274098

MOT13
Monocarboxylate transporter 13

1

0

High-throughput

0.513

High

1356118

SCRB1
Scavenger receptor class B member 1

1

0

High-throughput

0.513

High

1389672

MFSD3
Major facilitator superfamily domain-containing protein 3

1

0

High-throughput

0.513

High

1398189

DIESL
DGAT1/2-independent enzyme synthesizing storage lipids

1

0

High-throughput

0.513

High

1430701

F234A
Protein FAM234A

1

0

High-throughput

0.513

High

1434534

HEAT1
HEAT repeat-containing protein 1

1

0

High-throughput

0.513

High

1451850

T161A
Transmembrane protein 161A

1

0

High-throughput

0.513

High

1460039

T184B
Transmembrane protein 184B

1

0

High-throughput

0.513

High

85414

GPHRA
Golgi pH regulator A

2

1

High-throughput

0.504

High

165672

SCAM3
Secretory carrier-associated membrane protein 3

1

1

High-throughput

0.489

High

269072

ABCB7
Iron-sulfur clusters transporter ABCB7, mitochondrial

1

6

High-throughput

0.489

High

318170

IPO13
Importin-13

1

7

High-throughput

0.489

High

322770

RHBT3
Rho-related BTB domain-containing protein 3

1

15

High-throughput

0.489

High

1135947

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

7

High-throughput

0.489

High

1147581

UBE3C
Ubiquitin-protein ligase E3C

1

2

High-throughput

0.489

High

1230767

HEAT6
HEAT repeat-containing protein 6

1

2

High-throughput

0.489

High

1311125

UBR1
E3 ubiquitin-protein ligase UBR1

1

1

High-throughput

0.489

High

1311186

UBR2
E3 ubiquitin-protein ligase UBR2

1

1

High-throughput

0.489

High

1325552

LARG2
Xylosyl- and glucuronyltransferase LARGE2

1

7

High-throughput

0.489

High

1336549

MROH1
Maestro heat-like repeat-containing protein family member 1

1

3

High-throughput

0.489

High

1361685

ELYS
Protein ELYS

1

2

High-throughput

0.489

High

1388119

ERLEC
Endoplasmic reticulum lectin 1

1

5

High-throughput

0.489

High

1394114

SYNM
Asparaginyl-tRNA synthetase

1

3

High-throughput

0.489

High

1408180

ATF6B
Cyclic AMP-dependent transcription factor ATF-6 beta

1

6

High-throughput

0.489

High

1438541

TPC
Mitochondrial thiamine pyrophosphate carrier

1

8

High-throughput

0.489

High

1446718

TMM9B
Transmembrane protein 9B

1

4

High-throughput

0.489

High

1460038

DOP1B
Protein DOP1B

1

1

High-throughput

0.489

High

1460043

BIG1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1

1

5

High-throughput

0.489

High

270694

ATP9A
Probable phospholipid-transporting ATPase IIA

1

3

High-throughput

0.445

High

633873

MPRD
Cation-dependent mannose-6-phosphate receptor

1

2

High-throughput

0.445

High

1259093

ILDR2
Immunoglobulin-like domain-containing receptor 2

1

2

High-throughput

0.445

High

1316784

WDFY3
WD repeat and FYVE domain-containing protein 3

1

1

High-throughput

0.445

High

1323368

VPS52
Vacuolar protein sorting-associated protein 52 homolog

1

3

High-throughput

0.445

High

1392192

RUSF1
RUS family member 1

1

1

High-throughput

0.445

High

1349191

TLC3A
TLC domain-containing protein 3A

1

0

High-throughput

0.426

High

1460037

UB2J1
Ubiquitin-conjugating enzyme E2 J1

1

3

High-throughput

0.407

High

397765

NU5M
NADH-ubiquinone oxidoreductase chain 5

2

0

High-throughput

0.328

High

1350253

DC2L1
Cytoplasmic dynein 2 light intermediate chain 1

2

0

High-throughput

0.328

High

1431691

ARV1
Protein ARV1

2

0

High-throughput

0.328

High

1451059

FANCL
E3 ubiquitin-protein ligase FANCL

2

0

High-throughput

0.328

High

1205428

DB121
Beta-defensin 121

2

0

High-throughput

0.316

High

761059

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

0

High-throughput

0.292

High

1249611

TMT1B
Thiol S-methyltransferase TMT1B

1

0

High-throughput

0.279

Low

1437619

NJMU
Protein Njmu-R1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025