HitPredict

Interactor 1: LATS1 (O95835)
Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)
Gene: LATS1

Interactor 2: SIR4 (Q9Y6E7)
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial (EC 2.3.1.-) (NAD-dependent ADP-ribosyltransferase sirtuin-4) (EC 2.4.2.-) (NAD-dependent protein biotinylase sirtuin-4) (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-4) (EC 2.3.1.286) (Regulatory protein SIR2 homolog 4) (SIR2-like protein 4)
Gene: SIRT4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	33945069
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1130 Hs			1 314
+	Hs
		349258 LATS1_HUMAN (1-1130): 0: 925: 100.00		SIR3_HUMAN (39-312): 8.65e-87: 267: 27.34
+	Hs
		728505 AKT1_HUMAN (595-1079): 1.92e-140: 434: 24.60		SIR4_HUMAN (1-314): 1.07e-143: 409: 100.00
+	Hs
		728323 AKT1_HUMAN (595-1079): 1.92e-140: 434: 24.60		SIR2_HUMAN (39-296): 1.01e-88: 271: 24.06
+	Hs
		728336 AKT1_HUMAN (595-1079): 1.92e-140: 434: 24.60		SIR6_HUMAN (16-311): 6.4e-89: 271: 27.43
+	Hs
		728377 AKT1_HUMAN (595-1079): 1.92e-140: 434: 24.60		SIR1_HUMAN (28-308): 3e-83: 267: 22.76