Protein: SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial (EC 2.3.1.-) (NAD-dependent ADP-ribosyltransferase sirtuin-4) (EC 2.4.2.-) (NAD-dependent protein biotinylase sirtuin-4) (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-4) (EC 2.3.1.286) (Regulatory protein SIR2 homolog 4) (SIR2-like protein 4)

Gene: SIR4, SIRT4
Organism: Homo sapiens
Interactions: 117
UniProt ID: Q9Y6E7

Gene Ontology (top 5):
GO:0000820 - regulation of glutamine family amino acid metabolic process
GO:0003950 - NAD+ poly-ADP-ribosyltransferase activity
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1449515

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

13

Small-scale

0.691

High

533116

CH60
60 kDa heat shock protein, mitochondrial

4

5

High-throughput

0.691

High

575226

IDE
Insulin-degrading enzyme

3

8

Small-scale

0.650

High

522532

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

5

High-throughput

0.568

High

249686

SNX3
Sorting nexin-3

2

4

High-throughput

0.558

High

132895

ODPX
Pyruvate dehydrogenase protein X component, mitochondrial

1

5

High-throughput

0.515

High

425088

ADT2
ADP/ATP translocase 2

1

7

Small-scale

0.515

High

552459

ADT3
ADP/ATP translocase 3

1

7

Small-scale

0.515

High

951929

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

4

Small-scale

0.512

High

1101938

SKP2
S-phase kinase-associated protein 2

1

6

Small-scale

0.512

High

578570

BRAF
Serine/threonine-protein kinase B-raf

1

2

High-throughput

0.479

High

728505

AKT1
RAC-alpha serine/threonine-protein kinase

1

3

High-throughput

0.479

High

188580

BCAT2
Branched-chain-amino-acid aminotransferase, mitochondrial

1

0

Small-scale

0.458

High

61703

VWA8
von Willebrand factor A domain-containing protein 8

1

4

High-throughput

0.445

High

282144

MPPB
Mitochondrial-processing peptidase subunit beta

1

7

High-throughput

0.445

High

296682

AL1L1
Cytosolic 10-formyltetrahydrofolate dehydrogenase

1

7

High-throughput

0.445

High

302007

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

1

High-throughput

0.445

High

339382

ETHE1
Persulfide dioxygenase ETHE1, mitochondrial

1

1

High-throughput

0.445

High

354428

TOM40
Mitochondrial import receptor subunit TOM40 homolog

1

2

High-throughput

0.445

High

359774

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

3

High-throughput

0.445

High

423958

ALDH2
Aldehyde dehydrogenase, mitochondrial

1

7

High-throughput

0.445

High

425870

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

14

High-throughput

0.445

High

484699

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.445

High

539284

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

2

High-throughput

0.445

High

539449

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

5

High-throughput

0.445

High

547229

PYC
Pyruvate carboxylase, mitochondrial

1

15

High-throughput

0.445

High

554866

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

3

High-throughput

0.445

High

560935

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

1

4

High-throughput

0.445

High

657412

MAOM
NAD-dependent malic enzyme, mitochondrial

1

2

High-throughput

0.445

High

666382

THIL
Acetyl-CoA acetyltransferase, mitochondrial

1

1

High-throughput

0.445

High

686738

IVD
Isovaleryl-CoA dehydrogenase, mitochondrial

1

5

High-throughput

0.445

High

702735

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1

2

High-throughput

0.445

High

711443

SHC1
SHC-transforming protein 1

1

2

High-throughput

0.445

High

716649

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

1

2

High-throughput

0.445

High

717190

ECHM
Enoyl-CoA hydratase, mitochondrial

1

5

High-throughput

0.445

High

734035

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

1

3

High-throughput

0.445

High

761068

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

1

High-throughput

0.445

High

777640

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

1

3

High-throughput

0.445

High

786319

LONM
Lon protease homolog, mitochondrial

1

2

High-throughput

0.445

High

788285

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

5

High-throughput

0.445

High

829614

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

5

High-throughput

0.445

High

842059

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

2

High-throughput

0.445

High

877411

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

2

High-throughput

0.445

High

882975

EFTU
Elongation factor Tu, mitochondrial

1

6

High-throughput

0.445

High

888582

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

1

5

High-throughput

0.445

High

932968

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

9

High-throughput

0.445

High

1013039

RT09
Small ribosomal subunit protein uS9m

1

2

High-throughput

0.445

High

1035481

ODO1
2-oxoglutarate dehydrogenase complex component E1

1

2

High-throughput

0.445

High

1083814

MPPA
Mitochondrial-processing peptidase subunit alpha

1

7

High-throughput

0.445

High

1090607

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

3

High-throughput

0.445

High

1092693

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

5

High-throughput

0.445

High

1163718

PCKGM
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial

1

1

High-throughput

0.445

High

1187812

AL1L2
Mitochondrial 10-formyltetrahydrofolate dehydrogenase

1

7

High-throughput

0.445

High

1194777

ACSF3
Malonate--CoA ligase ACSF3, mitochondrial

1

2

High-throughput

0.445

High

1206261

PREP
Presequence protease, mitochondrial

1

8

High-throughput

0.445

High

1207195

SYAM
Alanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.445

High

1247925

C1TM
Monofunctional C1-tetrahydrofolate synthase, mitochondrial

1

1

High-throughput

0.445

High

1271632

DHX30
ATP-dependent RNA helicase DHX30

1

13

High-throughput

0.445

High

1273052

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

1

High-throughput

0.445

High

1289029

NLRX1
NLR family member X1

1

2

High-throughput

0.445

High

1289771

NT5D3
5'-nucleotidase domain-containing protein 3

1

1

High-throughput

0.445

High

1293479

NIT1
Deaminated glutathione amidase

1

1

High-throughput

0.445

High

1370920

GCDH
Glutaryl-CoA dehydrogenase, mitochondrial

1

5

High-throughput

0.445

High

1381797

FAKD4
FAST kinase domain-containing protein 4

1

1

High-throughput

0.445

High

1385544

P5CR2
Pyrroline-5-carboxylate reductase 2

1

3

High-throughput

0.445

High

1386097

ACSF2
Medium-chain acyl-CoA ligase ACSF2, mitochondrial

1

2

High-throughput

0.445

High

1390088

PTCD3
Small ribosomal subunit protein mS39

1

1

High-throughput

0.445

High

1394140

SUCB2
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

1

4

High-throughput

0.445

High

1401791

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

15

High-throughput

0.445

High

1406675

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

High-throughput

0.445

High

1436161

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

5

High-throughput

0.445

High

1436182

NT5D2
5'-nucleotidase domain-containing protein 2

1

1

High-throughput

0.445

High

1438823

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

5

High-throughput

0.445

High

1446021

SYSM
Serine--tRNA ligase, mitochondrial

1

3

High-throughput

0.445

High

1449388

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

2

High-throughput

0.445

High

1453772

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

4

High-throughput

0.445

High

1454827

SUCB1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

4

High-throughput

0.445

High

1458577

HDAC6
Protein deacetylase HDAC6

1

9

High-throughput

0.445

High

1460056

NB5R1
NADH-cytochrome b5 reductase 1

1

2

High-throughput

0.445

High

1460830

STML2
Stomatin-like protein 2, mitochondrial

1

1

High-throughput

0.445

High

1491807

RT18B
Small ribosomal subunit protein mS40

1

1

High-throughput

0.445

High

187585

FANCA
Fanconi anemia group A protein

1

1

Small-scale

0.437

High

349309

LATS1
Serine/threonine-protein kinase LATS1

1

5

Small-scale

0.437

High

275798

NDUS2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

1

0

High-throughput

0.426

High

348271

DCMC
Malonyl-CoA decarboxylase, mitochondrial

1

0

High-throughput

0.426

High

451650

GPX1
Glutathione peroxidase 1

1

0

High-throughput

0.426

High

568533

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

0

High-throughput

0.426

High

716470

PRDX5
Peroxiredoxin-5, mitochondrial

1

0

High-throughput

0.426

High

784889

HEM6
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

1

0

High-throughput

0.426

High

834386

GARS
Glycine--tRNA ligase

1

0

High-throughput

0.426

High

891072

NDUV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

1

0

High-throughput

0.426

High

902649

RT29
Small ribosomal subunit protein mS29

1

0

High-throughput

0.426

High

1011234

RT22
Small ribosomal subunit protein mS22

1

0

High-throughput

0.426

High

1094164

RM28
Large ribosomal subunit protein bL28m

1

0

High-throughput

0.426

High

1194516

NADK2
NAD kinase 2, mitochondrial

1

0

High-throughput

0.426

High

1211811

SYRM
Probable arginine--tRNA ligase, mitochondrial

1

0

High-throughput

0.426

High

1212557

CAF17
Iron-sulfur cluster assembly factor IBA57, mitochondrial

1

0

High-throughput

0.426

High

1235959

PDE12
2',5'-phosphodiesterase 12

1

0

High-throughput

0.426

High

1308737

MMAA
Methylmalonic aciduria type A protein, mitochondrial

1

0

High-throughput

0.426

High

1315361

THNS1
Threonine synthase-like 1

1

0

High-throughput

0.426

High

1338819

FAD1
FAD synthase

1

0

High-throughput

0.426

High

1350670

ALAT2
Alanine aminotransferase 2

1

0

High-throughput

0.426

High

1388004

RM38
Large ribosomal subunit protein mL38

1

0

High-throughput

0.426

High

1407337

MIPEP
Mitochondrial intermediate peptidase

1

0

High-throughput

0.426

High

1412633

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.426

High

1417460

HDHD5
Haloacid dehalogenase-like hydrolase domain-containing 5

1

0

High-throughput

0.426

High

1418340

RM01
Large ribosomal subunit protein uL1m

1

0

High-throughput

0.426

High

1419677

RM37
Large ribosomal subunit protein mL37

1

0

High-throughput

0.426

High

1432199

IPYR2
Inorganic pyrophosphatase 2, mitochondrial

1

0

High-throughput

0.426

High

1437135

RM44
Large ribosomal subunit protein mL44

1

0

High-throughput

0.426

High

1446069

RT30
Large ribosomal subunit protein mL65

1

0

High-throughput

0.426

High

1452675

RM39
Large ribosomal subunit protein mL39

1

0

High-throughput

0.426

High

1461482

DNPEP
Aspartyl aminopeptidase

1

0

High-throughput

0.426

High

1491019

ACOT9
Acyl-coenzyme A thioesterase 9, mitochondrial

1

0

High-throughput

0.426

High

1491219

RT23
Small ribosomal subunit protein mS23

1

0

High-throughput

0.426

High

483667

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

2

High-throughput

0.407

High

248255

NDK8
Putative nucleoside diphosphate kinase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025