Protein: SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (hSIRT3) (EC 2.3.1.286) (NAD-dependent protein delactylase sirtuin-3) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 3) (SIR2-like protein 3)

Gene: SIR3, SIRT3
Organism: Homo sapiens
Interactions: 99
UniProt ID: Q9NTG7

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006476 - protein deacetylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

998857

H31
Histone H3.1

2

10

Small-scale

0.812

High

533000

CH60
60 kDa heat shock protein, mitochondrial

5

5

Small-scale

0.723

High

1449515

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

13

Small-scale

0.691

High

1101912

SKP2
S-phase kinase-associated protein 2

2

6

Small-scale

0.650

High

724201

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

2

2

High-throughput

0.628

High

1384948

TRI43
Tripartite motif-containing protein 43

2

3

High-throughput

0.628

High

471273

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

2

3

Small-scale

0.624

High

1449508

SIR5
NAD-dependent protein deacylase sirtuin-5, mitochondrial

1

13

Small-scale

0.618

High

680523

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

2

5

Small-scale

0.612

High

423948

ALDH2
Aldehyde dehydrogenase, mitochondrial

2

7

Small-scale

0.611

High

1128192

DMC1
Meiotic recombination protein DMC1/LIM15 homolog

2

1

High-throughput

0.611

High

275397

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

2

0

High-throughput

0.602

High

369099

ASSY
Argininosuccinate synthase

2

0

High-throughput

0.602

High

1449516

RM42
Large ribosomal subunit protein mL42

2

0

High-throughput

0.602

High

483651

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

3

2

High-throughput

0.599

High

888568

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

2

5

Small-scale

0.595

High

333721

NDUAA
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

2

0

High-throughput

0.585

High

558437

XRCC6
X-ray repair cross-complementing protein 6

1

5

Small-scale

0.578

High

734012

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

1

3

Small-scale

0.578

High

1449509

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

4

Small-scale

0.578

High

653599

HEMH
Ferrochelatase, mitochondrial

2

0

High-throughput

0.576

High

245545

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

5

Small-scale

0.561

High

717168

ECHM
Enoyl-CoA hydratase, mitochondrial

1

5

Small-scale

0.561

High

1060301

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

1

2

Small-scale

0.561

High

896313

PEX5
Peroxisomal targeting signal 1 receptor

1

1

High-throughput

0.541

High

657689

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.537

High

690634

ANX13
Annexin A13

1

4

High-throughput

0.536

High

869251

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

1

High-throughput

0.536

High

946535

YBEY
Endoribonuclease YbeY

1

1

High-throughput

0.536

High

1293474

NIT1
Deaminated glutathione amidase

1

1

High-throughput

0.536

High

1308665

AHNK2
Protein AHNAK2

1

5

High-throughput

0.536

High

1352059

MICA1
[F-actin]-monooxygenase MICAL1

1

8

High-throughput

0.536

High

1389017

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

1

High-throughput

0.536

High

1392415

SYMM
Methionine--tRNA ligase, mitochondrial

1

2

High-throughput

0.536

High

1416427

SSBP3
Single-stranded DNA-binding protein 3

1

3

High-throughput

0.536

High

1433735

MTG2
Mitochondrial ribosome-associated GTPase 2

1

3

High-throughput

0.536

High

1437274

ELP3
Elongator complex protein 3

1

1

High-throughput

0.536

High

1449507

ACS2L
Acetyl-coenzyme A synthetase 2-like, mitochondrial

1

2

Small-scale

0.536

High

1449510

NPS3A
Protein NipSnap homolog 3A

1

1

High-throughput

0.536

High

1449513

RT18C
Small ribosomal subunit protein bS18m

1

3

High-throughput

0.536

High

1449514

RT18B
Small ribosomal subunit protein mS40

1

1

High-throughput

0.536

High

219753

FOXO3
Forkhead box protein O3

1

13

Small-scale

0.515

High

253788

UGDH
UDP-glucose 6-dehydrogenase

1

2

Small-scale

0.515

High

343072

HERC2
E3 ubiquitin-protein ligase HERC2

1

11

Small-scale

0.515

High

443994

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

3

Small-scale

0.515

High

535586

BIP
Endoplasmic reticulum chaperone BiP

1

10

Small-scale

0.515

High

573692

ENPL
Endoplasmin

1

3

Small-scale

0.515

High

761522

HS71L
Heat shock 70 kDa protein 1-like

1

6

Small-scale

0.515

High

801551

HSPA9
Stress-70 protein, mitochondrial

1

14

Small-scale

0.515

High

1217208

RIF1
Telomere-associated protein RIF1

1

10

Small-scale

0.515

High

1247858

MAP12
Methionine aminopeptidase 1D, mitochondrial

1

2

High-throughput

0.515

High

1325230

CMYA5
Cardiomyopathy-associated protein 5

1

7

Small-scale

0.515

High

1449511

TTF2
Transcription termination factor 2

1

17

Small-scale

0.515

High

278758

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

1

0

High-throughput

0.513

High

557493

SRC
Proto-oncogene tyrosine-protein kinase Src

1

0

High-throughput

0.513

High

641843

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

0

High-throughput

0.513

High

716744

ATPD
ATP synthase F(1) complex subunit delta, mitochondrial

1

0

High-throughput

0.513

High

764221

CAH5A
Carbonic anhydrase 5A, mitochondrial

1

0

High-throughput

0.513

High

1203463

OXLD1
Oxidoreductase-like domain-containing protein 1

1

0

High-throughput

0.513

High

1310453

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1028411

MDM2
E3 ubiquitin-protein ligase Mdm2

1

4

Small-scale

0.501

High

462812

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

1

0

Small-scale

0.493

High

75461

B3KMS0
Condensin complex subunit 1

1

3

Small-scale

0.479

High

279938

CISY
Citrate synthase, mitochondrial

1

6

Small-scale

0.479

High

339379

ETHE1
Persulfide dioxygenase ETHE1, mitochondrial

1

1

Small-scale

0.479

High

349258

LATS1
Serine/threonine-protein kinase LATS1

1

5

Small-scale

0.479

High

359751

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

3

Small-scale

0.479

High

405211

SODM
Superoxide dismutase [Mn], mitochondrial

1

1

Small-scale

0.479

High

539266

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

2

Small-scale

0.479

High

761898

HSP74
Heat shock 70 kDa protein 4

1

13

Small-scale

0.479

High

877392

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

2

Small-scale

0.479

High

907597

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

6

Small-scale

0.479

High

980408

H4
Histone H4

1

5

Small-scale

0.479

High

1118457

SNTB1
Beta-1-syntrophin

1

1

Small-scale

0.479

High

1137277

CND1
Condensin complex subunit 1

1

3

Small-scale

0.479

High

1142682

PDK1
[Pyruvate dehydrogenase

1

1

High-throughput

0.479

High

1142734

PDK2
[Pyruvate dehydrogenase

1

1

Small-scale

0.479

High

1163538

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

1

Small-scale

0.479

High

1255734

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.479

High

1367381

ESR2
Estrogen receptor beta

1

16

High-throughput

0.479

High

1406644

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

Small-scale

0.479

High

1409606

NIPS1
Protein NipSnap homolog 1

1

1

Small-scale

0.479

High

1436105

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

5

Small-scale

0.479

High

1449512

RUVB1
RuvB-like 1

1

4

Small-scale

0.479

High

249672

SNX3
Sorting nexin-3

1

4

High-throughput

0.470

High

331809

MTMR5
Myotubularin-related protein 5

1

2

Small-scale

0.470

High

1024284

PIPNA
Phosphatidylinositol transfer protein alpha isoform

1

0

Small-scale

0.458

High

1216547

STPG1
O(6)-methylguanine-induced apoptosis 2

1

0

High-throughput

0.458

High

1251609

HSDL2
Hydroxysteroid dehydrogenase-like protein 2

1

0

Small-scale

0.458

High

135713

DNM1L
Dynamin-1-like protein

1

4

High-throughput

0.457

High

522513

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

5

High-throughput

0.445

High

1097121

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

1

9

Small-scale

0.437

High

1387792

ARHGQ
Rho guanine nucleotide exchange factor 26

1

1

High-throughput

0.437

High

1416473

LS14B
Protein LSM14 homolog B

3

0

High-throughput

0.347

High

1419446

REG4
Regenerating islet-derived protein 4

2

0

High-throughput

0.328

High

705571

GRN
Progranulin

2

0

Small-scale

0.319

High

953837

C1QT8
Complement C1q tumor necrosis factor-related protein 8

1

0

High-throughput

0.279

Low

1295041

TMM25
Transmembrane protein 25

1

0

High-throughput

0.279

Low

1260345

PGAP1
GPI inositol-deacylase

1

0

Small-scale

0.269

Low


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Last updated: 11Aug2025