HitPredict

Interactor 1: RASH (P01112)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: HRAS

Interactor 2: MARK2 (Q7KZI7)
Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b)
Gene: MARK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30442766, 30639242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 788
+	Hs
		348748 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		MARK2_HUMAN (1-788): 0: 790: 100.00
+	Hs
		350286 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		MARK2_HUMAN (1-788): 0: 790: 100.00
+	Hs
		914159 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		MARK2_HUMAN (1-788): 0: 790: 100.00
+	Hs
		348523 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Hs
		349893 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Hs
		350628 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		MARK1_HUMAN (3-788): 0: 644: 63.22
+	Hs
		647864 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Hs
		349139 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Rn
		192821 RB11B_RAT (4-171): 1.34e-72: 219: 34.12		AAPK1_RAT (31-560): 2.85e-141: 429: 30.00