HitPredict

Interactor 1: RASH (P01112)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: HRAS

Interactor 2: RGPS2 (Q86X27)
Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2)
Gene: RALGPS2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30639242, 30194290
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RasGEF
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007265 - Ras protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 583
+	Hs
		348758 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		RGPS2_HUMAN (1-583): 0: 643: 100.00
+	Hs
		350308 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		RGPS2_HUMAN (1-583): 0: 643: 100.00
+	Hs
		348635 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		SOS1_HUMAN (18-469): 7.13e-103: 340: 19.83
+	Mm
		440302 RASN_MOUSE (1-188): 1.72e-88: 259: 86.70		RGL2_MOUSE (24-480): 2.79e-104: 333: 21.74
+	Hs
		350111 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		SOS1_HUMAN (18-469): 7.13e-103: 340: 19.83
+	Hs
		171531 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		RGL2_HUMAN (26-480): 5.4e-102: 327: 20.83
+	Mm
		699619 RASK_MOUSE (1-188): 1.68e-84: 249: 86.24		RGL2_MOUSE (24-480): 2.79e-104: 333: 21.74
+	Hs
		348818 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		RPGF6_HUMAN (18-462): 3.55e-96: 323: 15.79
+	Ce
		612367 LET60_CAEEL (1-181): 4.41e-89: 260: 76.80		Q19770_CAEEL (4-481): 1.37e-100: 320: 17.73
+	Ce
		105960 LET60_CAEEL (1-181): 4.41e-89: 260: 76.80		RPGF_CAEEL (18-473): 5.95e-94: 316: 16.83
+	Hs
		171533 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		RGL2_HUMAN (26-480): 5.4e-102: 327: 20.83
+	Hs
		348971 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		RGL1_HUMAN (16-462): 1.53e-97: 315: 20.42
+	Hs
		350126 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		GNDS_HUMAN (9-458): 1.82e-99: 324: 19.27
+	Hs
		350385 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		RPGF6_HUMAN (18-462): 3.55e-96: 323: 15.79
+	Dm
		442998 RAS1_DROME (1-175): 3.05e-92: 268: 81.22		Q86BI2_DROME (43-442): 5.07e-87: 287: 20.14
+	Dm
		443004 RAS1_DROME (1-175): 3.05e-92: 268: 81.22		Q9GR11_DROME (43-442): 6.86e-87: 287: 20.14
+	Hs
		348697 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		RGL3_HUMAN (14-454): 1.13e-89: 293: 21.70
+	Ce
		103461 LET60_CAEEL (1-181): 4.41e-89: 260: 76.80		G4SFM6_CAEEL (37-471): 1.61e-86: 288: 19.67
+	Ce
		612368 LET60_CAEEL (1-181): 4.41e-89: 260: 76.80		Q19852_CAEEL (37-471): 2.41e-86: 288: 19.67
+	Hs
		156389 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		RGRF2_HUMAN (6-290): 4.32e-88: 298: 28.67