HitPredict

Interactor 1: H2B1 (P02293)
Histone H2B.1 (Suppressor of Ty protein 12)
Gene: HTB1

Interactor 2: SWR1 (Q05471)
Helicase SWR1 (EC 3.6.4.12) (Swi2/Snf2-related 1)
Gene: SWR1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.906

Property	Details
Experiments	15045029, 19088068, 24507717, 37968396, 21179020
Identification Methods	tandem affinity purification, pull down, x-ray crystallography, affinity chromatography technology
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Histone~SNF2-rel_dom
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0006355 - regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 131 Sc			1 1514
+	Sc
		356014 H2B2_YEAST (1-131): 1.46e-45: 146: 96.95		SWR1_YEAST (1-1514): 0: 1057: 100.00
+	Hs
		229415 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		SMCA5_HUMAN (1033-1509): 3.54e-85: 304: 24.69
+	Hs
		229458 H2B1H_HUMAN (7-128): 3.89e-46: 147: 70.97		SMCA5_HUMAN (1033-1509): 3.54e-85: 304: 24.69
+	Hs
		229321 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		SMCA5_HUMAN (1033-1509): 3.54e-85: 304: 24.69
+	Hs
		1087449 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		CHD7_HUMAN (1114-1509): 6.46e-82: 301: 26.38
+	Hs
		707773 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		CHD7_HUMAN (1114-1509): 6.46e-82: 301: 26.38
+	Hs
		1018625 H2B1H_HUMAN (7-128): 3.89e-46: 147: 70.97		CHD3_HUMAN (1017-1463): 2.27e-80: 296: 24.89
+	Hs
		1307128 H2B1M_HUMAN (7-128): 9.18e-47: 148: 69.36		CHD8_HUMAN (1034-1508): 5.26e-80: 295: 23.70
+	Hs
		1087418 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		CHD8_HUMAN (1034-1508): 5.26e-80: 295: 23.70
+	Hs
		707612 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		CHD3_HUMAN (1017-1463): 2.27e-80: 296: 24.89
+	Hs
		707755 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		CHD8_HUMAN (1034-1508): 5.26e-80: 295: 23.70
+	Hs
		707647 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		CHD9_HUMAN (1108-1510): 5.26e-78: 288: 26.18
+	Hs
		1087343 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		EP400_HUMAN (1098-1509): 2.23e-76: 284: 27.52
+	Hs
		658684 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		SMCA1_HUMAN (1060-1503): 5.31e-78: 283: 26.51
+	Hs
		707713 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		EP400_HUMAN (1098-1509): 2.23e-76: 284: 27.52
+	Hs
		846990 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		SMCA4_HUMAN (1036-1496): 9.82e-72: 267: 19.60
+	Sc
		356040 H2B2_YEAST (1-131): 1.46e-45: 146: 96.95		ISW2_YEAST (1093-1503): 1.18e-72: 267: 25.94
+	Hs
		1087210 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		SRCAP_HUMAN (282-660): 5.08e-44: 178: 14.17
+	Hs
		707663 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		SRCAP_HUMAN (282-660): 5.08e-44: 178: 14.17
+	Sc
		355948 H2B2_YEAST (1-131): 1.46e-45: 146: 96.95		INO80_YEAST (997-1198): 1.6e-22: 107: 8.53