HitPredict

Interactor 1: H4 (P02309)
Histone H4
Gene: HHF1

Interactor 2: SET3 (P36124)
SET domain-containing protein 3
Gene: SET3

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.759

Property	Details
Experiments	19379692, 21179020
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CENP-T_C~SET
Common GO terms	GO:0005634 - nucleus GO:0006325 - chromatin organization GO:0006355 - regulation of DNA-templated transcription
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 103 Sc			1 751
+	Hs
		917879 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		NSD3_HUMAN (78-556): 5.55e-75: 266: 13.05
+	Hs
		331767 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		NSD2_HUMAN (122-556): 4.59e-74: 264: 13.29
+	Hs
		917762 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		NSD1_HUMAN (122-556): 1.12e-72: 260: 13.59
+	Hs
		917145 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		KMT2A_HUMAN (25-480): 9.79e-60: 222: 14.56
+	Hs
		918135 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		KMT2B_HUMAN (26-480): 9.72e-50: 191: 13.06
+	Hs
		917878 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		SETD2_HUMAN (164-702): 1.1e-47: 185: 12.46
+	Hs
		917843 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		DIDO1_HUMAN (16-229): 1.84e-41: 165: 16.74
+	Sc
		356466 H4_YEAST (1-103): 5.28e-47: 147: 100.00		SET1_YEAST (240-477): 4.36e-26: 117: 14.11
+	Hs
		917621 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		KMT2C_HUMAN (187-476): 3.3e-26: 118: 15.52
+	Hs
		152623 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		KMT2D_HUMAN (259-476): 5.94e-26: 117: 17.73
+	Hs
		68282 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		P20L1_HUMAN (81-180): 3.41e-24: 110: 23.00
+	Hs
		917858 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		PHF20_HUMAN (89-170): 1.56e-22: 105: 23.17