Protein: RN185
E3 ubiquitin-protein ligase RNF185 (EC 2.3.2.27) (RING finger protein 185)

Gene: RN185, RNF185
Organism: Homo sapiens
Interactions: 157
UniProt ID: Q96GF1

Gene Ontology (top 5):
GO:0005741 - mitochondrial outer membrane
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0006914 - autophagy

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

849409

UB2D1
Ubiquitin-conjugating enzyme E2 D1

4

20

Small-scale

0.898

High

919826

UB2D2
Ubiquitin-conjugating enzyme E2 D2

4

20

High-throughput

0.898

High

1292351

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

4

5

Small-scale

0.886

High

896353

UBE2K
Ubiquitin-conjugating enzyme E2 K

4

20

Small-scale

0.885

High

1292368

UB2D4
Ubiquitin-conjugating enzyme E2 D4

3

20

High-throughput

0.861

High

895880

UB2D3
Ubiquitin-conjugating enzyme E2 D3

3

20

Small-scale

0.857

High

1174918

TMUB2
Transmembrane and ubiquitin-like domain-containing protein 2

3

5

Small-scale

0.847

High

1282328

UB2E3
Ubiquitin-conjugating enzyme E2 E3

5

20

High-throughput

0.834

High

1292341

UB2E2
Ubiquitin-conjugating enzyme E2 E2

3

20

High-throughput

0.770

High

476198

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

20

Small-scale

0.754

High

874673

BI1
Bax inhibitor 1

5

3

High-throughput

0.717

High

299969

ERLN2
Erlin-2

5

12

Small-scale

0.709

High

1292346

RNF5
E3 ubiquitin-protein ligase RNF5

4

18

Small-scale

0.701

High

851870

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

20

High-throughput

0.698

High

908956

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

High-throughput

0.698

High

930352

UBC9
SUMO-conjugating enzyme UBC9

1

20

High-throughput

0.698

High

1119215

MBRL
Membralin

4

2

Small-scale

0.694

High

1292337

RN185
E3 ubiquitin-protein ligase RNF185

3

16

Small-scale

0.664

High

654661

CALX
Calnexin

3

2

High-throughput

0.657

High

266226

ERLN1
Erlin-1

3

11

Small-scale

0.656

High

1264262

BRI3B
BRI3-binding protein

3

2

Small-scale

0.656

High

1292363

AMFR
E3 ubiquitin-protein ligase AMFR

3

13

Small-scale

0.656

High

1292371

SRPRB
Signal recognition particle receptor subunit beta

3

4

Small-scale

0.656

High

277738

PRAF3
PRA1 family protein 3

2

2

Small-scale

0.631

High

1237447

CGAS
Cyclic GMP-AMP synthase

2

2

Small-scale

0.629

High

1256018

RHBL4
Rhomboid-related protein 4

2

2

High-throughput

0.628

High

1292345

SGMR1
Sigma non-opioid intracellular receptor 1

3

0

Small-scale

0.628

High

1033133

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

20

High-throughput

0.625

High

1284874

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

High-throughput

0.625

High

475137

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

20

Small-scale

0.618

High

509710

UBL4A
Ubiquitin-like protein 4A

1

20

Small-scale

0.618

High

872296

RD23B
UV excision repair protein RAD23 homolog B

1

20

Small-scale

0.618

High

924117

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

15

High-throughput

0.618

High

1231675

UB2J2
Ubiquitin-conjugating enzyme E2 J2

1

20

Small-scale

0.618

High

1292358

UBQL4
Ubiquilin-4

1

20

Small-scale

0.618

High

1292361

UBQL2
Ubiquilin-2

1

20

Small-scale

0.618

High

1292364

UBQL1
Ubiquilin-1

1

20

Small-scale

0.618

High

1292369

UB2J1
Ubiquitin-conjugating enzyme E2 J1

1

20

Small-scale

0.618

High

1292352

YIPF2
Protein YIPF2

3

2

High-throughput

0.616

High

976804

TAP2
Antigen peptide transporter 2

2

4

Small-scale

0.611

High

1016655

ASPH
Aspartyl/asparaginyl beta-hydroxylase

2

1

High-throughput

0.611

High

1240035

UBAC2
Ubiquitin-associated domain-containing protein 2

2

1

Small-scale

0.611

High

1231693

TM86A
Lysoplasmalogenase TMEM86A

2

2

High-throughput

0.606

High

1239801

CYAC3
Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3

2

2

High-throughput

0.606

High

1289488

YIPF6
Protein YIPF6

2

3

High-throughput

0.606

High

1035092

TUSC3
Tumor suppressor candidate 3

2

0

High-throughput

0.602

High

1292349

DERL1
Derlin-1

2

7

Small-scale

0.584

High

1292350

TM147
BOS complex subunit TMEM147

2

0

High-throughput

0.580

High

1283012

C102A
Coiled-coil domain-containing protein 102A

2

6

High-throughput

0.574

High

1292354

PCX3
Pecanex-like protein 3

2

7

High-throughput

0.574

High

1292347

YIPF4
Protein YIPF4

1

3

High-throughput

0.573

High

1287700

F241B
Protein FAM241B

2

1

High-throughput

0.553

High

636511

DNJB2
DnaJ homolog subfamily B member 2

1

3

High-throughput

0.536

High

1053799

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

1

High-throughput

0.536

High

1187514

ERMP1
Endoplasmic reticulum metallopeptidase 1

1

1

High-throughput

0.536

High

1283439

SPSB4
SPRY domain-containing SOCS box protein 4

1

13

High-throughput

0.536

High

1292343

SPSB2
SPRY domain-containing SOCS box protein 2

1

12

High-throughput

0.536

High

72152

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

20

High-throughput

0.528

High

217347

TYOBP
TYRO protein tyrosine kinase-binding protein

1

0

High-throughput

0.513

High

295759

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

0

High-throughput

0.513

High

1134697

DIK1A
Divergent protein kinase domain 1A

1

0

High-throughput

0.513

High

1219692

SGPP2
Sphingosine-1-phosphate phosphatase 2

1

0

High-throughput

0.513

High

1292370

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.513

High

151135

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

1

Small-scale

0.512

High

395472

A4
Amyloid-beta precursor protein

1

4

High-throughput

0.501

High

328372

S1PR4
Sphingosine 1-phosphate receptor 4

1

7

High-throughput

0.489

High

538812

GLUT4
Solute carrier family 2, facilitated glucose transporter member 4

1

1

High-throughput

0.489

High

600825

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

8

High-throughput

0.489

High

626718

EDNRA
Endothelin-1 receptor

1

4

High-throughput

0.489

High

676808

SSR1
Somatostatin receptor type 1

1

7

High-throughput

0.489

High

686258

GASR
Gastrin/cholecystokinin type B receptor

1

4

High-throughput

0.489

High

782458

P2RY2
P2Y purinoceptor 2

1

8

High-throughput

0.489

High

872082

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

2

High-throughput

0.489

High

1153721

STYK1
Tyrosine-protein kinase STYK1

1

6

High-throughput

0.489

High

1202711

P2RY8
P2Y purinoceptor 8

1

8

High-throughput

0.489

High

1233410

NIN
Ninein

1

11

High-throughput

0.489

High

1236332

AR6P6
ADP-ribosylation factor-like protein 6-interacting protein 6

1

1

High-throughput

0.489

High

1255497

ST7L
Suppressor of tumorigenicity 7 protein-like

1

2

High-throughput

0.489

High

1292338

PLPR2
Phospholipid phosphatase-related protein type 2

1

1

High-throughput

0.489

High

1292342

KCNKG
Potassium channel subfamily K member 16

1

1

High-throughput

0.489

High

1292362

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

7

High-throughput

0.481

High

122269

RN103
E3 ubiquitin-protein ligase RNF103

1

8

High-throughput

0.479

High

213624

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

11

Small-scale

0.479

High

234849

ACSL4
Long-chain-fatty-acid--CoA ligase 4

1

1

High-throughput

0.479

High

297084

TOM70
Mitochondrial import receptor subunit TOM70

1

7

Small-scale

0.479

High

348862

RASN
GTPase NRas

1

1

High-throughput

0.479

High

350448

RASK
GTPase KRas

1

1

High-throughput

0.479

High

390452

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

2

Small-scale

0.479

High

391099

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

Small-scale

0.479

High

393317

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

4

High-throughput

0.479

High

529556

CFTR
Cystic fibrosis transmembrane conductance regulator

1

4

Small-scale

0.479

High

538356

ENPL
Endoplasmin

1

8

Small-scale

0.479

High

730330

PRS7
26S proteasome regulatory subunit 7

1

13

Small-scale

0.479

High

847605

BAP31
B-cell receptor-associated protein 31

1

4

Small-scale

0.479

High

875221

TERA
Transitional endoplasmic reticulum ATPase

1

5

Small-scale

0.479

High

883853

TMM33
Transmembrane protein 33

1

1

Small-scale

0.479

High

894967

SRP54
Signal recognition particle subunit SRP54

1

1

Small-scale

0.479

High

941298

RNF4
E3 ubiquitin-protein ligase RNF4

1

14

High-throughput

0.479

High

966456

EXOSX
Exosome complex component 10

1

4

High-throughput

0.479

High

1055239

ERG1
Squalene monooxygenase

1

1

High-throughput

0.479

High

1088291

CP51A
Lanosterol 14-alpha demethylase

1

1

Small-scale

0.479

High

1128973

S27A3
Long-chain fatty acid transport protein 3

1

2

High-throughput

0.479

High

1165849

LMBRL
Protein LMBR1L

1

3

High-throughput

0.479

High

1188350

ATG9A
Autophagy-related protein 9A

1

2

High-throughput

0.479

High

1192169

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

Small-scale

0.479

High

1240525

ATAD1
Outer mitochondrial transmembrane helix translocase

1

15

High-throughput

0.479

High

1251700

NPL4
Nuclear protein localization protein 4 homolog

1

1

High-throughput

0.479

High

1263610

ATLA1
Atlastin-1

1

2

Small-scale

0.479

High

1272225

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

1

1

High-throughput

0.479

High

1287134

FAF2
FAS-associated factor 2

1

9

Small-scale

0.479

High

1292340

RN170
E3 ubiquitin-protein ligase RNF170

1

2

High-throughput

0.479

High

1292344

PHB2
Prohibitin-2

1

6

Small-scale

0.479

High

1292360

SRP68
Signal recognition particle subunit SRP68

1

2

Small-scale

0.479

High

825726

MTR1B
Melatonin receptor type 1B

1

5

High-throughput

0.464

High

307844

ZRAB2
Zinc finger Ran-binding domain-containing protein 2

1

0

Small-scale

0.458

High

839045

EMD
Emerin

1

0

Small-scale

0.458

High

1021940

SEC20
Vesicle transport protein SEC20

1

0

Small-scale

0.458

High

1292359

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.458

High

1241573

MOT11
Monocarboxylate transporter 11

1

4

High-throughput

0.445

High

122067

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

6

Small-scale

0.437

High

156337

PSA7
Proteasome subunit alpha type-7

1

16

Small-scale

0.437

High

212171

HTSF1
17S U2 SnRNP complex component HTATSF1

1

8

Small-scale

0.437

High

537992

KPYM
Pyruvate kinase PKM

1

2

Small-scale

0.437

High

556651

CBR1
Carbonyl reductase [NADPH] 1

1

3

High-throughput

0.437

High

564153

HSP76
Heat shock 70 kDa protein 6

1

6

Small-scale

0.437

High

573045

PRS6A
26S proteasome regulatory subunit 6A

1

17

Small-scale

0.437

High

638175

PSA4
Proteasome subunit alpha type-4

1

16

Small-scale

0.437

High

656291

PSA5
Proteasome subunit alpha type-5

1

16

Small-scale

0.437

High

786077

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

Small-scale

0.437

High

819832

PSMD8
26S proteasome non-ATPase regulatory subunit 8

1

2

Small-scale

0.437

High

822498

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

3

High-throughput

0.437

High

893726

PSA6
Proteasome subunit alpha type-6

1

19

Small-scale

0.437

High

907125

PRS8
26S proteasome regulatory subunit 8

1

16

Small-scale

0.437

High

929616

RACK1
Small ribosomal subunit protein RACK1

1

9

Small-scale

0.437

High

941814

RBM6
RNA-binding protein 6

1

7

Small-scale

0.437

High

1075071

MARE2
Microtubule-associated protein RP/EB family member 2

1

1

Small-scale

0.437

High

1190594

CF120
UPF0669 protein C6orf120

1

1

High-throughput

0.437

High

1292355

APMAP
Adipocyte plasma membrane-associated protein

1

1

High-throughput

0.437

High

1292356

SAR1A
Small COPII coat GTPase SAR1A

1

1

High-throughput

0.437

High

1292372

MAGD1
Melanoma-associated antigen D1

1

5

Small-scale

0.437

High

1292353

COA1
Cytochrome c oxidase assembly factor 1 homolog

2

0

High-throughput

0.328

High

62040

MADL2
Myeloid-associated differentiation marker-like protein 2

2

0

High-throughput

0.316

High

1000233

NIPA4
Magnesium transporter NIPA4

2

0

High-throughput

0.316

High

1022750

MALL
MAL-like protein

2

0

High-throughput

0.316

High

1126724

M4A13
Membrane-spanning 4-domains subfamily A member 13

2

0

High-throughput

0.316

High

1292339

TMM19
Transmembrane protein 19

2

0

High-throughput

0.316

High

1288873

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

0

High-throughput

0.299

High

361703

APOC3
Apolipoprotein C-III

1

0

High-throughput

0.279

Low

1203207

LHPL1
LHFPL tetraspan subfamily member 1 protein

1

0

High-throughput

0.279

Low

1292348

ABHEA
Protein ABHD14A

1

0

High-throughput

0.279

Low

1292357

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.279

Low

1292365

TNF18
Tumor necrosis factor ligand superfamily member 18

1

0

High-throughput

0.279

Low

928796

RL38
Large ribosomal subunit protein eL38

1

0

Small-scale

0.249

Low

1282920

TR19L
Tumor necrosis factor receptor superfamily member 19L

1

0

Small-scale

0.249

Low

1292366

HIG1A
HIG1 domain family member 1A, mitochondrial

1

0

Small-scale

0.249

Low

1292367

RRP44
Exosome complex exonuclease RRP44

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024