HitPredict

Interactor 1: APOA1 (P02647)
Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I (Apolipoprotein A-I(1-242))]
Gene: APOA1

Interactor 2: LCAT (P04180)
Phosphatidylcholine-sterol acyltransferase (EC 2.3.1.43) (1-alkyl-2-acetylglycerophosphocholine esterase) (EC 3.1.1.47) (Lecithin-cholesterol acyltransferase) (Phospholipid-cholesterol acyltransferase) (Platelet-activating factor acetylhydrolase) (PAF acetylhydrolase)
Gene: LCAT

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 0.60 0.748

The method score is based on:

Property Details
Experiments 1644835, 1587806, 3104518, 10026251, 4335615, 10222237, 15654758, 17676061
Identification Methods pull down, biochemical, enzymatic study, mass spectrometry studies of complexes, affinity chromatography technology
Interaction Type direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0006656 - phosphatidylcholine biosynthetic process
GO:0008203 - cholesterol metabolic process
GO:0030301 - cholesterol transport
and 6 others

more...
Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 267
Hs

1 440
+ Rn
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024