HitPredict

Interactor 1: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: GRAP (Q13588)
GRB2-related adapter protein
Gene: GRAP

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	8647802
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1, SH2~SH2, SH2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1130 Hs			1 217
+	Hs
		362234 ABL1_HUMAN (1-1130): 0: 987: 100.00		GRB2_HUMAN (1-216): 1.09e-69: 214: 59.72
+	Hs
		362107 ABL1_HUMAN (1-1130): 0: 987: 100.00		ABL1_HUMAN (3-180): 4.03e-52: 182: 31.69
+	Hs
		72383 A9UF07_HUMAN (25-1130): 0: 948: 99.73		GRB2_HUMAN (1-216): 1.09e-69: 214: 59.72
+	Hs
		362121 ABL1_HUMAN (1-1130): 0: 987: 100.00		FYN_HUMAN (3-217): 2.02e-40: 146: 24.17
+	Hs
		362151 ABL1_HUMAN (1-1130): 0: 987: 100.00		NCK1_HUMAN (5-145): 1.05e-23: 99: 35.47
+	Hs
		362199 ABL1_HUMAN (1-1130): 0: 987: 100.00		ABL2_HUMAN (4-137): 3.83e-23: 98.6: 38.13
+	Mm
		362432 ABL1_MOUSE (1-1130): 0: 903: 85.54		ABL1_MOUSE (3-180): 4.06e-52: 182: 31.69
+	Hs
		362147 ABL1_HUMAN (1-1130): 0: 987: 100.00		VAV_HUMAN (2-60): 2.15e-16: 79.2: 33.90
+	Hs
		292795 ABL1_HUMAN (1-1130): 0: 987: 100.00		GRAP2_HUMAN (3-55): 1.73e-11: 64: 33.96
+	Hs
		362129 ABL1_HUMAN (1-1130): 0: 987: 100.00		HCK_HUMAN (81-215): 2.36e-10: 61.5: 18.98
+	Hs
		362143 ABL1_HUMAN (1-1130): 0: 987: 100.00		SRC_HUMAN (149-214): 3.66e-10: 60.7: 23.53
+	Mm
		362454 ABL1_MOUSE (1-1130): 0: 903: 85.54		NCK1_MOUSE (5-145): 1.51e-23: 98.2: 34.88
+	Hs
		840943 ABL2_HUMAN (10-1130): 0: 774: 52.53		GRB2_HUMAN (1-216): 1.09e-69: 214: 59.72
+	Hs
		440427 ABL2_HUMAN (10-1130): 0: 774: 52.53		FYN_HUMAN (3-217): 2.02e-40: 146: 24.17
+	Hs
		593935 ABL2_HUMAN (10-1130): 0: 774: 52.53		NCK1_HUMAN (5-145): 1.05e-23: 99: 35.47
+	Hs
		840931 ABL2_HUMAN (10-1130): 0: 774: 52.53		ABL2_HUMAN (4-137): 3.83e-23: 98.6: 38.13
+	Hs
		473378 ABL2_HUMAN (10-1130): 0: 774: 52.53		HCK_HUMAN (81-215): 2.36e-10: 61.5: 18.98
+	Hs
		557158 ABL2_HUMAN (10-1130): 0: 774: 52.53		SRC_HUMAN (149-214): 3.66e-10: 60.7: 23.53
+	Dm
		362458 ABL_DROME (38-886): 3e-175: 559: 45.92		ABL_DROME (3-185): 7.47e-54: 187: 34.39