HitPredict

Interactor 1: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: SHE (Q5VZ18)
SH2 domain-containing adapter protein E
Gene: SHE

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	9315092
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0001784 - phosphotyrosine residue binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1130 Hs			1 495
+	Hs
		362299 ABL1_HUMAN (1-1130): 0: 987: 100.00		SHB_HUMAN (122-490): 9.84e-62: 211: 36.13
+	Hs
		362256 ABL1_HUMAN (1-1130): 0: 987: 100.00		BTK_HUMAN (174-493): 6.63e-55: 196: 18.18
+	Hs
		362176 ABL1_HUMAN (1-1130): 0: 987: 100.00		SHC1_HUMAN (258-494): 2.26e-53: 191: 20.49
+	Hs
		362347 ABL1_HUMAN (1-1130): 0: 987: 100.00		SHD_HUMAN (158-493): 1.6e-46: 166: 33.91
+	Hs
		362121 ABL1_HUMAN (1-1130): 0: 987: 100.00		FYN_HUMAN (335-492): 9.58e-42: 158: 17.16
+	Hs
		362107 ABL1_HUMAN (1-1130): 0: 987: 100.00		ABL1_HUMAN (280-493): 1.41e-39: 155: 19.82
+	Hs
		362143 ABL1_HUMAN (1-1130): 0: 987: 100.00		SRC_HUMAN (261-492): 9.24e-41: 155: 16.93
+	Hs
		362151 ABL1_HUMAN (1-1130): 0: 987: 100.00		NCK1_HUMAN (182-488): 4.68e-42: 155: 16.57
+	Hs
		72380 A9UF07_HUMAN (25-1130): 0: 948: 99.73		SHC1_HUMAN (258-494): 2.26e-53: 191: 20.49
+	Hs
		362199 ABL1_HUMAN (1-1130): 0: 987: 100.00		ABL2_HUMAN (271-492): 6.5e-38: 150: 20.89
+	Hs
		362234 ABL1_HUMAN (1-1130): 0: 987: 100.00		GRB2_HUMAN (339-493): 6.55e-38: 139: 19.50
+	Hs
		72383 A9UF07_HUMAN (25-1130): 0: 948: 99.73		GRB2_HUMAN (339-493): 6.55e-38: 139: 19.50
+	Hs
		362282 ABL1_HUMAN (1-1130): 0: 987: 100.00		GRAP_HUMAN (388-476): 4.94e-23: 98.8: 28.89
+	Mm
		362454 ABL1_MOUSE (1-1130): 0: 903: 85.54		NCK1_MOUSE (182-488): 7.57e-42: 155: 15.68
+	Mm
		362432 ABL1_MOUSE (1-1130): 0: 903: 85.54		ABL1_MOUSE (280-493): 2.43e-39: 154: 19.82
+	Hs
		711271 ABL2_HUMAN (10-1130): 0: 774: 52.53		SHC1_HUMAN (258-494): 2.26e-53: 191: 20.49
+	Hs
		440427 ABL2_HUMAN (10-1130): 0: 774: 52.53		FYN_HUMAN (335-492): 9.58e-42: 158: 17.16
+	Hs
		557158 ABL2_HUMAN (10-1130): 0: 774: 52.53		SRC_HUMAN (261-492): 9.24e-41: 155: 16.93
+	Hs
		593935 ABL2_HUMAN (10-1130): 0: 774: 52.53		NCK1_HUMAN (182-488): 4.68e-42: 155: 16.57