Protein: SHB
SH2 domain-containing adapter protein B

Gene: SHB
Organism: Homo sapiens
Interactions: 77
UniProt ID: Q15464

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001784 - phosphotyrosine residue binding
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

222088

NCK2
Cytoplasmic protein NCK2

3

19

High-throughput

0.861

High

710257

EPHA2
Ephrin type-A receptor 2

2

20

High-throughput

0.754

High

362299

ABL1
Tyrosine-protein kinase ABL1

1

19

Small-scale

0.747

High

541506

FGFR1
Fibroblast growth factor receptor 1

1

20

Small-scale

0.724

High

557320

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.724

High

584545

VAV
Proto-oncogene vav

1

20

Small-scale

0.724

High

699762

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

20

Small-scale

0.724

High

849069

ZAP70
Tyrosine-protein kinase ZAP-70

1

20

Small-scale

0.724

High

1090337

EPS8
Epidermal growth factor receptor kinase substrate 8

1

20

Small-scale

0.724

High

1094303

LCP2
Lymphocyte cytosolic protein 2

1

20

Small-scale

0.724

High

472067

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

532083

KIT
Mast/stem cell growth factor receptor Kit

1

20

High-throughput

0.692

High

778070

VGFR2
Vascular endothelial growth factor receptor 2

1

20

Small-scale

0.691

High

363325

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.647

High

410863

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

641603

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.647

High

658709

JAK1
Tyrosine-protein kinase JAK1

1

20

Small-scale

0.647

High

911925

JAK3
Tyrosine-protein kinase JAK3

1

20

Small-scale

0.647

High

1145734

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

463532

LYN
Tyrosine-protein kinase Lyn

1

19

High-throughput

0.618

High

614690

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

20

High-throughput

0.618

High

619063

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

19

Small-scale

0.618

High

648521

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.618

High

855632

CRK
Adapter molecule crk

1

20

Small-scale

0.618

High

987661

GRB2
Growth factor receptor-bound protein 2

1

20

Small-scale

0.618

High

1147326

EPHA7
Ephrin type-A receptor 7

1

20

High-throughput

0.618

High

1149252

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.602

High

966345

1433G
14-3-3 protein gamma

2

20

High-throughput

0.601

High

640175

EPHA1
Ephrin type-A receptor 1

1

20

High-throughput

0.590

High

220375

LAT
Linker for activation of T-cells family member 1

2

8

Small-scale

0.584

High

375545

RASK
GTPase KRas

2

20

High-throughput

0.584

High

520073

ANDR
Androgen receptor

1

20

High-throughput

0.536

High

1149249

FBLI1
Filamin-binding LIM protein 1

1

20

High-throughput

0.536

High

1149254

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.536

High

219178

LTOR5
Ragulator complex protein LAMTOR5

1

0

High-throughput

0.518

High

575828

IL2RB
Interleukin-2 receptor subunit beta

1

20

Small-scale

0.516

High

190364

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.513

High

728678

IL2RG
Cytokine receptor common subunit gamma

1

20

Small-scale

0.501

High

706132

S10A2
Protein S100-A2

1

5

High-throughput

0.489

High

189577

STX7
Syntaxin-7

1

5

High-throughput

0.479

High

226038

STX6
Syntaxin-6

1

2

High-throughput

0.479

High

301067

RL1D1
Ribosomal L1 domain-containing protein 1

1

1

High-throughput

0.479

High

374617

RASH
GTPase HRas

1

20

High-throughput

0.479

High

424909

ADT2
ADP/ATP translocase 2

1

8

High-throughput

0.479

High

540465

LAMP1
Lysosome-associated membrane glycoprotein 1

1

11

High-throughput

0.479

High

552251

ADT3
ADP/ATP translocase 3

1

8

High-throughput

0.479

High

556100

CADH1
Cadherin-1

1

12

High-throughput

0.479

High

603990

CXA1
Gap junction alpha-1 protein

1

13

High-throughput

0.479

High

631238

RAB5A
Ras-related protein Rab-5A

1

12

High-throughput

0.479

High

642889

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

14

High-throughput

0.479

High

845650

MUC18
Cell surface glycoprotein MUC18

1

19

High-throughput

0.479

High

901828

RAB9A
Ras-related protein Rab-9A

1

15

High-throughput

0.479

High

936334

AFAD
Afadin

1

20

High-throughput

0.479

High

976284

RB11A
Ras-related protein Rab-11A

1

9

High-throughput

0.479

High

978025

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

988388

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

1004063

CXAR
Coxsackievirus and adenovirus receptor

1

12

High-throughput

0.479

High

1031388

IFM3
Interferon-induced transmembrane protein 3

1

8

High-throughput

0.479

High

1041079

CAV1
Caveolin-1

1

10

High-throughput

0.479

High

1045317

TF65
Transcription factor p65

1

10

High-throughput

0.479

High

1087119

STX4
Syntaxin-4

1

6

High-throughput

0.479

High

1107743

SQSTM
Sequestosome-1

1

3

High-throughput

0.479

High

1113182

CUL3
Cullin-3

1

11

High-throughput

0.479

High

1144914

RAB35
Ras-related protein Rab-35

1

10

High-throughput

0.479

High

1149244

OCLN
Occludin

1

5

High-throughput

0.479

High

1149245

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.479

High

1149247

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

15

High-throughput

0.479

High

1149248

CXD3
Gap junction delta-3 protein

1

13

High-throughput

0.479

High

1149251

BICD1
Protein bicaudal D homolog 1

1

20

High-throughput

0.479

High

1149253

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

1149255

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1149257

LAMP3
Lysosome-associated membrane glycoprotein 3

1

11

High-throughput

0.479

High

964622

DCAF7
DDB1- and CUL4-associated factor 7

1

3

High-throughput

0.445

High

630808

RAB4A
Ras-related protein Rab-4A

1

11

High-throughput

0.437

High

1149246

ATG9A
Autophagy-related protein 9A

1

2

High-throughput

0.437

High

1149250

CK052
Uncharacterized protein C11orf52

1

2

High-throughput

0.437

High

1149256

XPO7
Exportin-7

1

2

High-throughput

0.437

High


Service provided by Combinatics, Japan

Last updated: 11Aug2025