HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: CYFP1 (Q7L576)
Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) (p140sra-1)
Gene: CYFIP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000902 - cell morphogenesis GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0048471 - perinuclear region of cytoplasm GO:0051015 - actin filament binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 1253
+	Hs
		363704 EGFR_HUMAN (1-1210): 0: 1246: 100.00		CYFP2_HUMAN (1-1253): 0: 2070: 85.92
+	Hs
		463995 RET_HUMAN (412-1058): 7.91e-132: 433: 23.02		CYFP1_HUMAN (1-1253): 0: 2086: 100.00
+	Hs
		710851 EPHB2_HUMAN (642-1067): 2.14e-123: 408: 28.22		CYFP1_HUMAN (1-1253): 0: 2086: 100.00
+	Hs
		1147358 EPHA7_HUMAN (653-1064): 3.04e-119: 396: 27.51		CYFP1_HUMAN (1-1253): 0: 2086: 100.00
+	Hs
		710878 EPHB2_HUMAN (642-1067): 2.14e-123: 408: 28.22		CYFP2_HUMAN (1-1253): 0: 2070: 85.92
+	Hs
		932113 EPHA4_HUMAN (660-1016): 3.23e-121: 401: 31.52		CYFP2_HUMAN (1-1253): 0: 2070: 85.92
+	Hs
		1147405 EPHA7_HUMAN (653-1064): 3.04e-119: 396: 27.51		CYFP2_HUMAN (1-1253): 0: 2070: 85.92
+	Hs
		710329 EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79		CYFP1_HUMAN (1-1253): 0: 2086: 100.00
+	Hs
		710423 EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79		CYFP2_HUMAN (1-1253): 0: 2070: 85.92