HitPredict

Interactor 1: CXCL7 (P02775)
Platelet basic protein (PBP) (C-X-C motif chemokine 7) (Leukocyte-derived growth factor) (LDGF) (Macrophage-derived growth factor) (MDGF) (Small-inducible cytokine B7) [Cleaved into: Connective tissue-activating peptide III (CTAP-III) (LA-PF4) (Low-affinity platelet factor IV); TC-2; Connective tissue-activating peptide III(1-81) (CTAP-III(1-81)); Beta-thromboglobulin (Beta-TG); Neutrophil-activating peptide 2(74) (NAP-2(74)); Neutrophil-activating peptide 2(73) (NAP-2(73)); Neutrophil-activating peptide 2 (NAP-2); TC-1; Neutrophil-activating peptide 2(1-66) (NAP-2(1-66)); Neutrophil-activating peptide 2(1-63) (NAP-2(1-63))]
Gene: PPBP

Interactor 2: CXCR1 (P25024)
C-X-C chemokine receptor type 1 (CXC-R1) (CXCR-1) (CDw128a) (High affinity interleukin-8 receptor A) (IL-8R A) (IL-8 receptor type 1) (CD antigen CD181)
Gene: CXCR1

Species: Homo sapiens

Source: dip

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	8702798
Identification Methods	biochemical
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0030593 - neutrophil chemotaxis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 128 Hs			1 350
+	Hs
		364042 CXCL7_HUMAN (1-128): 2.12e-41: 135: 100.00		CXCR2_HUMAN (1-349): 3.91e-65: 212: 75.07
+	Mm
		500672 CXCL2_MOUSE (51-127): 2.03e-29: 104: 49.35		CXCR2_MOUSE (3-339): 5.77e-73: 232: 69.23
+	Hs
		625736 CXCL5_HUMAN (49-128): 2.33e-28: 101: 45.00		CXCR1_HUMAN (1-340): 2.74e-73: 232: 100.00
+	Hs
		217751 CXL13_HUMAN (51-127): 5.3e-24: 90.6: 24.36		CXCR3_HUMAN (1-349): 6.16e-77: 242: 37.61
+	Mm
		522397 GROA_MOUSE (53-123): 1.4e-27: 99: 59.16		CXCR2_MOUSE (3-339): 5.77e-73: 232: 69.23
+	Hs
		364080 PLF4_HUMAN (51-123): 5.15e-23: 87.9: 50.69		CXCR3_HUMAN (1-349): 6.16e-77: 242: 37.61
+	Hs
		625737 CXCL6_HUMAN (50-128): 2.91e-26: 96.3: 40.51		CXCR1_HUMAN (1-340): 2.74e-73: 232: 100.00
+	Hs
		448987 GROA_HUMAN (57-127): 3.17e-26: 95.9: 57.75		CXCR1_HUMAN (1-340): 2.74e-73: 232: 100.00
+	Mm
		291524 CXL10_MOUSE (48-126): 3.81e-21: 82.8: 28.40		CXCR3_MOUSE (1-335): 2.34e-77: 243: 37.39
+	Hs
		486184 IL8_HUMAN (50-127): 6.11e-25: 92.5: 43.04		CXCR1_HUMAN (1-340): 2.74e-73: 232: 100.00
+	Mm
		291525 CXCL9_MOUSE (54-119): 4.78e-20: 80.9: 38.81		CXCR3_MOUSE (1-335): 2.34e-77: 243: 37.39
+	Hs
		830623 CXCL9_HUMAN (53-119): 1.2e-18: 77.5: 33.82		CXCR3_HUMAN (1-349): 6.16e-77: 242: 37.61
+	Hs
		625748 CXCL5_HUMAN (49-128): 2.33e-28: 101: 45.00		CXCR2_HUMAN (1-349): 3.91e-65: 212: 75.07
+	Hs
		587767 CXCL2_HUMAN (51-127): 1.75e-27: 99.4: 50.65		CXCR2_HUMAN (1-349): 3.91e-65: 212: 75.07
+	Hs
		587786 CXCL3_HUMAN (57-127): 1.67e-26: 96.7: 50.70		CXCR2_HUMAN (1-349): 3.91e-65: 212: 75.07
+	Hs
		217747 CXL13_HUMAN (51-127): 5.3e-24: 90.6: 24.36		CXCR5_HUMAN (12-349): 1.84e-67: 218: 33.24
+	Hs
		625758 CXCL6_HUMAN (50-128): 2.91e-26: 96.3: 40.51		CXCR2_HUMAN (1-349): 3.91e-65: 212: 75.07
+	Hs
		448988 GROA_HUMAN (57-127): 3.17e-26: 95.9: 57.75		CXCR2_HUMAN (1-349): 3.91e-65: 212: 75.07
+	Hs
		486185 IL8_HUMAN (50-127): 6.11e-25: 92.5: 43.04		CXCR2_HUMAN (1-349): 3.91e-65: 212: 75.07
+	Hs
		217753 CXL13_HUMAN (51-127): 5.3e-24: 90.6: 24.36		ACKR4_HUMAN (3-349): 7.98e-66: 213: 28.82