Protein: PKP3
Plakophilin-3

Gene: PKP3
Organism: Homo sapiens
Interactions: 153
UniProt ID: Q9Y446

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0002159 - desmosome assembly
GO:0002718 - regulation of cytokine production involved in immune response
GO:0002934 - desmosome organization
GO:0003723 - RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1392091

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

3

0

High-throughput

0.816

High

1307961

ARMC8
Armadillo repeat-containing protein 8

1

8

Small-scale

0.740

High

1036823

DSG1
Desmoglein-1

1

20

Small-scale

0.713

High

1128566

DSC3
Desmocollin-3

1

20

Small-scale

0.713

High

1419440

RHBT2
Rho-related BTB domain-containing protein 2

1

20

High-throughput

0.691

High

853874

MK09
Mitogen-activated protein kinase 9

3

11

High-throughput

0.667

High

1200964

SGO2
Shugoshin 2

3

1

High-throughput

0.667

High

1416494

RBM24
RNA-binding protein 24

3

10

High-throughput

0.667

High

1308333

LACC1
Purine nucleoside phosphorylase LACC1

3

0

High-throughput

0.638

High

406938

MAS
Proto-oncogene Mas

2

4

High-throughput

0.628

High

845247

GDF5
Growth/differentiation factor 5

2

3

High-throughput

0.628

High

1340943

IL31R
Interleukin-31 receptor subunit alpha

2

7

High-throughput

0.628

High

1400528

CDK15
Cyclin-dependent kinase 15

2

9

High-throughput

0.628

High

1462119

OAZ3
Ornithine decarboxylase antizyme 3

2

2

High-throughput

0.628

High

1491045

FCF1
rRNA-processing protein FCF1 homolog

2

1

High-throughput

0.628

High

1491320

KIF3A
Kinesin-like protein KIF3A

2

9

High-throughput

0.628

High

1367672

ESR2
Estrogen receptor beta

1

20

High-throughput

0.625

High

577934

PLAK
Junction plakoglobin

1

19

Small-scale

0.621

High

1037059

DSC2
Desmocollin-2

1

20

Small-scale

0.621

High

374300

RASN
GTPase NRas

1

20

High-throughput

0.618

High

375036

RASH
GTPase HRas

1

20

High-throughput

0.618

High

376133

RASK
GTPase KRas

1

20

High-throughput

0.618

High

397301

ESR1
Estrogen receptor

1

20

High-throughput

0.618

High

520650

RARA
Retinoic acid receptor alpha

1

20

Small-scale

0.618

High

556438

CADH1
Cadherin-1

1

20

High-throughput

0.618

High

581388

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

765149

CTNB1
Catenin beta-1

1

19

High-throughput

0.618

High

872929

SOX2
Transcription factor SOX-2

1

20

High-throughput

0.618

High

910266

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

955781

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

1218043

MYOME
Myomegalin

2

20

High-throughput

0.611

High

1336786

SIA7C
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

2

3

High-throughput

0.611

High

1389658

MITOK
Mitochondrial potassium channel

3

2

High-throughput

0.609

High

1292634

GPBP1
Vasculin

2

0

High-throughput

0.602

High

1447491

ANLN
Anillin

2

8

High-throughput

0.584

High

1408366

PKP2
Plakophilin-2

1

15

High-throughput

0.575

High

1358066

CPLX3
Complexin-3

2

1

High-throughput

0.574

High

1143113

KPCD1
Serine/threonine-protein kinase D1

2

8

High-throughput

0.571

High

1158209

MK14
Mitogen-activated protein kinase 14

2

13

High-throughput

0.571

High

1460240

CTNA3
Catenin alpha-3

2

20

Small-scale

0.565

High

292308

B3GL1
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

2

1

High-throughput

0.558

High

748668

DSG3
Desmoglein-3

1

20

Small-scale

0.552

High

1120847

DSG2
Desmoglein-2

1

20

Small-scale

0.552

High

175274

SC16A
Protein transport protein Sec16A

1

9

High-throughput

0.536

High

190096

FOXP2
Forkhead box protein P2

1

7

High-throughput

0.536

High

245298

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

11

High-throughput

0.536

High

602857

AATC
Aspartate aminotransferase, cytoplasmic

1

2

High-throughput

0.536

High

733477

CCR1
C-C chemokine receptor type 1

1

3

High-throughput

0.536

High

846545

MATR3
Matrin-3

1

6

High-throughput

0.536

High

943164

STX17
Syntaxin-17

1

2

High-throughput

0.536

High

1026294

CLH1
Clathrin heavy chain 1

1

3

High-throughput

0.536

High

1250717

NPSR1
Neuropeptide S receptor

1

8

High-throughput

0.536

High

1292358

ZC3C1
Zinc finger C3HC-type protein 1

1

2

High-throughput

0.536

High

1326767

CCD82
Coiled-coil domain-containing protein 82

1

1

High-throughput

0.536

High

1332817

FNDC5
Fibronectin type III domain-containing protein 5

1

2

High-throughput

0.536

High

1366349

FAN
Protein FAN

1

11

High-throughput

0.536

High

1381477

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

3

High-throughput

0.536

High

1417111

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

15

High-throughput

0.536

High

1417218

SRRT
Serrate RNA effector molecule homolog

1

2

High-throughput

0.536

High

1448010

MBNL1
Muscleblind-like protein 1

1

1

High-throughput

0.536

High

1452898

GTSE1
G2 and S phase-expressed protein 1

1

2

High-throughput

0.536

High

1490825

SSUH2
Protein SSUH2 homolog

1

2

High-throughput

0.536

High

1491321

RBM8A
RNA-binding protein 8A

1

6

High-throughput

0.536

High

730983

1433S
14-3-3 protein sigma

1

20

High-throughput

0.515

High

570641

GFAP
Glial fibrillary acidic protein

1

10

High-throughput

0.515

High

1111387

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

1273979

DYM
Dymeclin

1

0

High-throughput

0.513

High

1330644

CCYL1
Cyclin-Y-like protein 1

1

0

High-throughput

0.513

High

1436416

PAAT
ATPase PAAT

1

0

High-throughput

0.513

High

1453214

AHSP
Alpha-hemoglobin-stabilizing protein

1

0

High-throughput

0.513

High

325371

OR2A4
Olfactory receptor 2A4

1

2

High-throughput

0.489

High

876416

PTSS1
Phosphatidylserine synthase 1

1

2

High-throughput

0.489

High

1023921

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

5

High-throughput

0.489

High

1181360

CR021
UPF0711 protein C18orf21

1

1

High-throughput

0.489

High

1380571

PIGT
GPI-anchor transamidase component PIGT

1

1

High-throughput

0.489

High

1460987

FBXL4
F-box/LRR-repeat protein 4

1

4

High-throughput

0.489

High

437046

K1C18
Keratin, type I cytoskeletal 18

1

18

Small-scale

0.481

High

587845

DESP
Desmoplakin

1

20

Small-scale

0.481

High

1064490

DSC1
Desmocollin-1

1

20

Small-scale

0.481

High

159930

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

20

High-throughput

0.479

High

173601

XPO1
Exportin-1

1

11

High-throughput

0.479

High

251348

CIDEA
Lipid transferase CIDEA

1

2

High-throughput

0.479

High

285538

EED
Polycomb protein EED

1

20

High-throughput

0.479

High

297716

PIAS1
E3 SUMO-protein ligase PIAS1

1

4

High-throughput

0.479

High

331443

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

364077

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.479

High

386395

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

13

High-throughput

0.479

High

590111

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

630108

BTF3
Transcription factor BTF3

1

3

High-throughput

0.479

High

696951

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

7

High-throughput

0.479

High

714543

PML
Protein PML

1

20

High-throughput

0.479

High

769596

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.479

High

786952

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

5

High-throughput

0.479

High

900241

FXR1
RNA-binding protein FXR1

1

13

Small-scale

0.479

High

965363

WDR5
WD repeat-containing protein 5

1

12

High-throughput

0.479

High

980593

H4
Histone H4

1

1

High-throughput

0.479

High

1045944

TF65
Transcription factor p65

1

10

High-throughput

0.479

High

1106763

SMAD4
Mothers against decapentaplegic homolog 4

1

7

High-throughput

0.479

High

1125272

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

12

High-throughput

0.479

High

1138196

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.479

High

1138805

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.479

High

1141095

KIF14
Kinesin-like protein KIF14

1

18

High-throughput

0.479

High

1151415

TRIP4
Activating signal cointegrator 1

1

1

High-throughput

0.479

High

1152310

MARE1
Microtubule-associated protein RP/EB family member 1

1

10

Small-scale

0.479

High

1235699

NIPBL
Nipped-B-like protein

1

14

High-throughput

0.479

High

1258094

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

2

Small-scale

0.479

High

1289343

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

7

High-throughput

0.479

High

1332730

ZBT38
Zinc finger and BTB domain-containing protein 38

1

6

Small-scale

0.479

High

1368221

HDAC2
Histone deacetylase 2

1

17

High-throughput

0.479

High

1372222

MED12
Mediator of RNA polymerase II transcription subunit 12

1

12

High-throughput

0.479

High

1380285

FBXW7
F-box/WD repeat-containing protein 7

1

20

High-throughput

0.479

High

1384314

SH3K1
SH3 domain-containing kinase-binding protein 1

1

5

High-throughput

0.479

High

1402933

CK5P2
CDK5 regulatory subunit-associated protein 2

1

20

Small-scale

0.479

High

1428599

DDX24
ATP-dependent RNA helicase DDX24

1

7

High-throughput

0.479

High

1430657

CCDC8
Coiled-coil domain-containing protein 8

1

5

High-throughput

0.479

High

1433144

CHM4B
Charged multivesicular body protein 4b

1

5

High-throughput

0.479

High

1436580

ECT2
Protein ECT2

1

18

High-throughput

0.479

High

1452438

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

1

4

High-throughput

0.479

High

1458565

HDAC6
Protein deacetylase HDAC6

1

20

High-throughput

0.479

High

1459430

ZRAN1
Ubiquitin thioesterase ZRANB1

1

20

High-throughput

0.479

High

1453770

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

1

High-throughput

0.470

High

194407

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

316466

RMP
Unconventional prefoldin RPB5 interactor 1

1

0

Small-scale

0.458

High

1161093

FSCN1
Fascin

1

0

High-throughput

0.458

High

1279255

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.458

High

1339246

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

1491322

SCC4
MAU2 chromatid cohesion factor homolog

1

0

High-throughput

0.458

High

564604

CFTR
Cystic fibrosis transmembrane conductance regulator

1

6

High-throughput

0.445

High

756422

MCM7
DNA replication licensing factor MCM7

1

16

Small-scale

0.445

High

906373

GPC3
Glypican-3

1

1

High-throughput

0.445

High

1249460

OLFM4
Olfactomedin-4

1

1

High-throughput

0.445

High

1397594

CI072
Guanine nucleotide exchange factor C9orf72

1

3

Small-scale

0.445

High

1429175

NAA50
N-alpha-acetyltransferase 50

1

1

High-throughput

0.445

High

158027

CTRO
Citron Rho-interacting kinase

1

12

High-throughput

0.437

High

377799

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.437

High

1041716

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

1

Small-scale

0.437

High

1389432

RNF31
E3 ubiquitin-protein ligase RNF31

1

20

High-throughput

0.437

High

1409915

ZFY21
Zinc finger FYVE domain-containing protein 21

1

5

Small-scale

0.437

High

1428436

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

9

High-throughput

0.437

High

261333

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.426

High

1414735

RSRP1
Arginine/serine-rich protein 1

1

0

High-throughput

0.426

High

1418173

RM13
Large ribosomal subunit protein uL13m

1

0

High-throughput

0.426

High

528532

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

1

High-throughput

0.407

High

554274

BMP4
Bone morphogenetic protein 4

1

4

High-throughput

0.407

High

1295250

DOPP1
Dolichyldiphosphatase 1

2

0

High-throughput

0.318

High

1324700

ELMD1
ELMO domain-containing protein 1

2

0

High-throughput

0.318

High

1332385

IQUB
IQ motif and ubiquitin-like domain-containing protein

2

0

High-throughput

0.316

High

1081729

CF210
Cilia- and flagella- associated protein 210

1

0

High-throughput

0.279

Low

1165360

SYT16
Synaptotagmin-16

1

0

High-throughput

0.279

Low

219668

B2L11
Bcl-2-like protein 11

1

0

High-throughput

0.232

Low

1207795

TMM31
Transmembrane protein 31

1

0

High-throughput

0.232

Low

1253218

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.232

Low

1400951

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025