Protein: PKP4
Plakophilin-4 (p0071)

Gene: PKP4
Organism: Homo sapiens
Interactions: 164
UniProt ID: Q99569

Gene Ontology (top 5):
GO:0000922 - spindle pole
GO:0001533 - cornified envelope
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005856 - cytoskeleton

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

749802

CADH5
Cadherin-5

3

20

Small-scale

0.863

High

937542

CADH8
Cadherin-8

3

20

High-throughput

0.855

High

556300

CADH1
Cadherin-1

3

20

Small-scale

0.849

High

764985

CTNB1
Catenin beta-1

3

18

High-throughput

0.847

High

375867

RASK
GTPase KRas

3

20

High-throughput

0.827

High

1307908

ARMC8
Armadillo repeat-containing protein 8

2

8

Small-scale

0.806

High

374156

RASN
GTPase NRas

2

20

High-throughput

0.754

High

374871

RASH
GTPase HRas

2

20

High-throughput

0.754

High

978245

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

396783

ESR1
Estrogen receptor

2

20

High-throughput

0.737

High

1401921

ERBIN
Erbin

5

14

Small-scale

0.724

High

937572

CAD12
Cadherin-12

1

20

High-throughput

0.691

High

1405319

CLC11
C-type lectin domain family 11 member A

4

2

High-throughput

0.691

High

1063562

GOGA2
Golgin subfamily A member 2

3

13

High-throughput

0.675

High

845473

PE2R3
Prostaglandin E2 receptor EP3 subtype

3

5

High-throughput

0.667

High

174662

PDZD2
PDZ domain-containing protein 2

2

20

Small-scale

0.634

High

355098

APBA3
Amyloid-beta A4 precursor protein-binding family A member 3

2

19

High-throughput

0.628

High

641243

FGFR2
Fibroblast growth factor receptor 2

2

20

High-throughput

0.628

High

669242

NK1R
Substance-P receptor

2

9

High-throughput

0.628

High

1351521

HAVR2
Hepatitis A virus cellular receptor 2

2

1

High-throughput

0.628

High

1405314

CTNA3
Catenin alpha-3

2

20

High-throughput

0.628

High

1122322

SCRIB
Protein scribble homolog

2

20

Small-scale

0.621

High

618282

CADH2
Cadherin-2

1

20

Small-scale

0.621

High

1128544

DSC3
Desmocollin-3

1

20

Small-scale

0.621

High

1331602

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

11

High-throughput

0.618

High

126764

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

341131

DIRA3
GTP-binding protein Di-Ras3

1

20

High-throughput

0.618

High

466429

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

581254

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

601417

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

872668

SOX2
Transcription factor SOX-2

1

17

High-throughput

0.618

High

910179

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

953632

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

955512

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

956455

RAB2A
Ras-related protein Rab-2A

1

11

High-throughput

0.618

High

962416

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

962814

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.618

High

976509

RB11A
Ras-related protein Rab-11A

1

7

High-throughput

0.618

High

988644

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1015707

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

1145076

RAB35
Ras-related protein Rab-35

1

12

High-throughput

0.618

High

1151837

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

1270957

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

1366871

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.618

High

1367100

ESR2
Estrogen receptor beta

1

20

High-throughput

0.618

High

1396619

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.618

High

1405302

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1405304

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

873882

KCNJ5
G protein-activated inward rectifier potassium channel 4

2

0

High-throughput

0.602

High

167525

TX1B3
Tax1-binding protein 3

2

20

High-throughput

0.601

High

1091562

DLG1
Disks large homolog 1

2

9

Small-scale

0.595

High

890040

PSN1
Presenilin-1

1

5

Small-scale

0.586

High

349214

LATS1
Serine/threonine-protein kinase LATS1

2

9

High-throughput

0.584

High

1195263

TM52B
Transmembrane protein 52B

2

1

High-throughput

0.574

High

783386

TRI23
E3 ubiquitin-protein ligase TRIM23

1

8

High-throughput

0.573

High

1405298

LZTS2
Leucine zipper putative tumor suppressor 2

1

19

High-throughput

0.573

High

1213082

RHG21
Rho GTPase-activating protein 21

2

8

High-throughput

0.571

High

518898

CCL3
C-C motif chemokine 3

1

2

High-throughput

0.536

High

711588

NK3R
Neuromedin-K receptor

1

8

High-throughput

0.536

High

761287

RYK
Tyrosine-protein kinase RYK

1

20

High-throughput

0.536

High

846437

MATR3
Matrin-3

1

6

High-throughput

0.536

High

876633

NEST
Nestin

1

16

High-throughput

0.536

High

1026192

CLH1
Clathrin heavy chain 1

1

3

High-throughput

0.536

High

1036679

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

20

High-throughput

0.536

High

1154425

STK11
Serine/threonine-protein kinase STK11

1

2

High-throughput

0.536

High

1161856

AMHR2
Anti-Muellerian hormone type-2 receptor

1

4

High-throughput

0.536

High

1371632

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

11

High-throughput

0.536

High

1400296

CC85A
Coiled-coil domain-containing protein 85A

1

4

High-throughput

0.536

High

1405299

RGAP1
Rac GTPase-activating protein 1

1

6

High-throughput

0.536

High

1405310

GPC5B
G-protein coupled receptor family C group 5 member B

1

3

High-throughput

0.536

High

1405311

FLRT1
Leucine-rich repeat transmembrane protein FLRT1

1

5

High-throughput

0.536

High

1405316

CLC4A
C-type lectin domain family 4 member A

1

3

High-throughput

0.536

High

1405318

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

3

High-throughput

0.536

High

1405322

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

10

High-throughput

0.536

High

1405324

BACE2
Beta-secretase 2

1

1

High-throughput

0.536

High

1405325

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

2

High-throughput

0.536

High

261859

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.513

High

1391378

MRAP2
Melanocortin-2 receptor accessory protein 2

1

0

High-throughput

0.513

High

185953

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

7

High-throughput

0.501

High

1006095

DLG4
Disks large homolog 4

1

12

High-throughput

0.501

High

1341091

INADL
InaD-like protein

1

20

High-throughput

0.501

High

866799

CAZA2
F-actin-capping protein subunit alpha-2

1

3

High-throughput

0.489

High

1178870

CF184
Cilia- and flagella-associated protein 184

1

1

High-throughput

0.489

High

1289393

URP2
Fermitin family homolog 3

1

3

High-throughput

0.489

High

1405309

GTSE1
G2 and S phase-expressed protein 1

1

2

High-throughput

0.489

High

1405306

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.486

High

587779

DESP
Desmoplakin

1

17

Small-scale

0.481

High

1257107

PAXI1
PAX-interacting protein 1

1

10

High-throughput

0.481

High

1348452

LNX1
E3 ubiquitin-protein ligase LNX

1

20

Small-scale

0.481

High

1353528

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

5

High-throughput

0.481

High

174594

TRI66
Tripartite motif-containing protein 66

1

15

High-throughput

0.479

High

226179

STX6
Syntaxin-6

1

2

High-throughput

0.479

High

299346

FLOT1
Flotillin-1

1

4

High-throughput

0.479

High

327420

ZFPL1
Zinc finger protein-like 1

1

3

High-throughput

0.479

High

331257

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

372939

MYC
Myc proto-oncogene protein

1

11

High-throughput

0.479

High

440183

LCK
Tyrosine-protein kinase Lck

1

16

High-throughput

0.479

High

463722

LYN
Tyrosine-protein kinase Lyn

1

16

High-throughput

0.479

High

540638

LAMP1
Lysosome-associated membrane glycoprotein 1

1

9

High-throughput

0.479

High

583102

VATB1
V-type proton ATPase subunit B, kidney isoform

1

2

High-throughput

0.479

High

604170

CXA1
Gap junction alpha-1 protein

1

14

High-throughput

0.479

High

657665

GCSP
Glycine dehydrogenase

1

3

High-throughput

0.479

High

710445

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.479

High

715734

MARCS
Myristoylated alanine-rich C-kinase substrate

1

9

High-throughput

0.479

High

764416

CTNA1
Catenin alpha-1

1

20

High-throughput

0.479

High

845771

MUC18
Cell surface glycoprotein MUC18

1

5

High-throughput

0.479

High

888270

MCM2
DNA replication licensing factor MCM2

1

15

High-throughput

0.479

High

914331

EFNA4
Ephrin-A4

1

3

High-throughput

0.479

High

931886

EPHA5
Ephrin type-A receptor 5

1

20

High-throughput

0.479

High

932121

EPHA4
Ephrin type-A receptor 4

1

20

High-throughput

0.479

High

936428

AFAD
Afadin

1

20

High-throughput

0.479

High

975196

ARF6
ADP-ribosylation factor 6

1

5

High-throughput

0.479

High

1004176

CXAR
Coxsackievirus and adenovirus receptor

1

3

High-throughput

0.479

High

1041241

CAV1
Caveolin-1

1

7

High-throughput

0.479

High

1045683

TF65
Transcription factor p65

1

8

High-throughput

0.479

High

1087255

STX4
Syntaxin-4

1

5

High-throughput

0.479

High

1140738

KIF14
Kinesin-like protein KIF14

1

13

High-throughput

0.479

High

1144658

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

20

High-throughput

0.479

High

1146462

KS6A2
Ribosomal protein S6 kinase alpha-2

1

8

High-throughput

0.479

High

1147414

EPHA7
Ephrin type-A receptor 7

1

20

High-throughput

0.479

High

1157042

NTRK3
NT-3 growth factor receptor

1

20

High-throughput

0.479

High

1159818

OCLN
Occludin

1

4

High-throughput

0.479

High

1233438

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.479

High

1289284

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

6

High-throughput

0.479

High

1322961

CXD3
Gap junction delta-3 protein

1

14

High-throughput

0.479

High

1326319

NIN
Ninein

1

15

High-throughput

0.479

High

1353253

PARD3
Partitioning defective 3 homolog

1

20

High-throughput

0.479

High

1387833

ZBT10
Zinc finger and BTB domain-containing protein 10

1

4

Small-scale

0.479

High

1399276

LRRC7
Leucine-rich repeat-containing protein 7

1

15

Small-scale

0.479

High

1405300

DNJC5
DnaJ homolog subfamily C member 5

1

3

High-throughput

0.479

High

1405301

SAV1
Protein salvador homolog 1

1

19

High-throughput

0.479

High

1405303

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

1405305

E41LA
Band 4.1-like protein 4A

1

13

High-throughput

0.479

High

1405307

ANLN
Anillin

1

8

High-throughput

0.479

High

1405308

LATS2
Serine/threonine-protein kinase LATS2

1

11

High-throughput

0.479

High

1405313

ZRAN1
Ubiquitin thioesterase ZRANB1

1

13

High-throughput

0.479

High

1405315

BRPF3
Bromodomain and PHD finger-containing protein 3

1

9

High-throughput

0.479

High

328124

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

7

High-throughput

0.457

High

616229

PGAM1
Phosphoglycerate mutase 1

1

1

High-throughput

0.457

High

190467

COPT1
High affinity copper uptake protein 1

1

1

High-throughput

0.445

High

471753

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

20

High-throughput

0.445

High

800556

VATA
V-type proton ATPase catalytic subunit A

1

3

High-throughput

0.445

High

1063069

S20A2
Sodium-dependent phosphate transporter 2

1

1

High-throughput

0.445

High

1090076

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

20

High-throughput

0.445

High

1155095

UT2
Urea transporter 2

1

2

High-throughput

0.445

High

1186185

INAVA
Innate immunity activator protein

1

2

High-throughput

0.445

High

1251177

ZNT10
Calcium/manganese antiporter SLC30A10

1

5

High-throughput

0.445

High

1251888

CCNI2
Cyclin-I2

1

8

High-throughput

0.445

High

1310930

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

6

High-throughput

0.445

High

1346763

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

6

High-throughput

0.445

High

1400117

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

9

High-throughput

0.445

High

1401103

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

20

High-throughput

0.445

High

1405312

SL9A2
Sodium/hydrogen exchanger 2

1

5

High-throughput

0.445

High

1405317

S12A4
Solute carrier family 12 member 4

1

2

High-throughput

0.445

High

1405320

ITM2B
Integral membrane protein 2B

1

4

High-throughput

0.445

High

1405323

PCDGD
Protocadherin gamma-B1

1

2

High-throughput

0.445

High

139969

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

2

High-throughput

0.437

High

1293123

TMM17
Transmembrane protein 17

1

3

High-throughput

0.437

High

1381943

CK052
Uncharacterized protein C11orf52

1

5

High-throughput

0.437

High

1396778

SNX27
Sorting nexin-27

1

19

High-throughput

0.437

High

1405321

NINL
Ninein-like protein

1

13

High-throughput

0.437

High

1405297

SPSB2
SPRY domain-containing SOCS box protein 2

1

14

High-throughput

0.407

High

1328058

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

3

0

High-throughput

0.356

High

1248417

CP054
Transmembrane protein C16orf54

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025